Pilsicainide hydrochloride
- Product Name
- Pilsicainide hydrochloride
- CAS No.
- 88069-49-2
- Chemical Name
- Pilsicainide hydrochloride
- Synonyms
- Pilsinic;Rizumcote;Alisrythm;Tatsupilljin;PILSICAININIDE;Pilsicainide hydrochoride;Pilsicainide-Hydrochlordie;Pilzicainide hydrochloride;PILSICAINIDE HYDROCHLORIDE;Pilsicainide hydrochloride USP/EP/BP
- CBNumber
- CB9699294
- Molecular Formula
- C17H24N2O
- Formula Weight
- 272.39
- MOL File
- 88069-49-2.mol
Pilsicainide hydrochloride Property
- Melting point:
- 212-214°
- storage temp.
- room temp
- solubility
- Chloroform (Slightly), Water (Slightly)
- form
- powder
- color
- white to beige
Safety
- RIDADR
- UN 2811 6.1 / PGIII
- WGK Germany
- 3
- HS Code
- 2933.99.7000
- Toxicity
- LD50 in mice (mg/kg): 410 s.c. (Miyano, 1985)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- P0026
- Product name
- Pilsicainide hydrochloride
- Purity
- ≥98% (HPLC)
- Packaging
- 10MG
- Price
- $97.5
- Updated
- 2023/06/20
- Product number
- P0026
- Product name
- Pilsicainide hydrochloride
- Purity
- ≥98% (HPLC)
- Packaging
- 50MG
- Price
- $382
- Updated
- 2023/06/20
- Product number
- P2634
- Product name
- Pilsicainide Hydrochloride
- Packaging
- 50MG
- Price
- $154
- Updated
- 2024/03/01
- Product number
- P2634
- Product name
- Pilsicainide Hydrochloride
- Packaging
- 250MG
- Price
- $456
- Updated
- 2024/03/01
- Product number
- P441508
- Product name
- Pilsicainide Hydrochloride
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
Pilsicainide hydrochloride Chemical Properties,Usage,Production
Description
Pilsicainide hydrochloride is a new pynolizidine lidocaine derivative with antiarrhythmic activity. It is the first pharmaceutical product introduced by Suntory and was solely developed in Japan. The compound is reported to be highly effective in the treatment of premature ventricular contraction. It has no anticholinergic or CNS activity and is not as likely as other class 1C antiarrhythmics to have restricted indications.
Originator
Suntory (Japan)
Uses
Pilsicainide hydrochloride has been used as a sodium channel blocker:
- to study its effects on electrophysiological parameters in guinea pig pulmonary vein preparation
- to study its effects on Ca2+?release and arrhythmic events in Andersen-Tawil syndrome induced pluripotent stem cells (ATS-iPSC)-derived cardiomyocytes
- to study its electrophysiological effects on the guinea pig atrium
brand name
Sunrhythm
Biochem/physiol Actions
Pilsicainide hydrochloride is a pure sodium channel blocker and an open channel blocker of Na+1 channels. Pilsicainide was defined as a pure sodium channel blocker. The compound is classified as a class Ic antiarrhythmic drug, and was originally developed in Japan. Similar to Lidocaine, Pilsicainide binds to open channels, but slowly. Pilsicainide is capable of selectively blocking the late currents in the mutant Na(+) channels that show dominant abnormal burst openings such as in δKPQ mutants. The compound is used to induce Brugada syndrome (BS) in animal models.
Pilsicainide hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Pilsicainide hydrochloride Suppliers
View Lastest Price from Pilsicainide hydrochloride manufacturers
- Product
- Pilsicainide hydrochloride 88069-49-2
- Price
- US $1.00-1.00/KG
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 50tons
- Release date
- 2020-05-11
- Product
- Pilsicainide hydrochloride 88069-49-2
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-11
- Product
- Pilsicainide hydrochloride 88069-49-2
- Price
- US $1.00/kg
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2018-12-21