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Pilsicainide hydrochloride

Product Name
Pilsicainide hydrochloride
CAS No.
88069-49-2
Chemical Name
Pilsicainide hydrochloride
Synonyms
Pilsinic;Rizumcote;Alisrythm;Tatsupilljin;PILSICAININIDE;Pilsicainide hydrochoride;Pilsicainide-Hydrochlordie;Pilzicainide hydrochloride;PILSICAINIDE HYDROCHLORIDE;Pilsicainide hydrochloride USP/EP/BP
CBNumber
CB9699294
Molecular Formula
C17H24N2O
Formula Weight
272.39
MOL File
88069-49-2.mol
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Pilsicainide hydrochloride Property

Melting point:
212-214°
storage temp. 
room temp
solubility 
Chloroform (Slightly), Water (Slightly)
form 
powder
color 
white to beige
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Safety

RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
HS Code 
2933.99.7000
Toxicity
LD50 in mice (mg/kg): 410 s.c. (Miyano, 1985)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P0026
Product name
Pilsicainide hydrochloride
Purity
≥98% (HPLC)
Packaging
10MG
Price
$97.5
Updated
2023/06/20
Sigma-Aldrich
Product number
P0026
Product name
Pilsicainide hydrochloride
Purity
≥98% (HPLC)
Packaging
50MG
Price
$382
Updated
2023/06/20
TCI Chemical
Product number
P2634
Product name
Pilsicainide Hydrochloride
Packaging
50MG
Price
$154
Updated
2024/03/01
TCI Chemical
Product number
P2634
Product name
Pilsicainide Hydrochloride
Packaging
250MG
Price
$456
Updated
2024/03/01
TRC
Product number
P441508
Product name
Pilsicainide Hydrochloride
Packaging
10mg
Price
$45
Updated
2021/12/16
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Pilsicainide hydrochloride Chemical Properties,Usage,Production

Description

Pilsicainide hydrochloride is a new pynolizidine lidocaine derivative with antiarrhythmic activity. It is the first pharmaceutical product introduced by Suntory and was solely developed in Japan. The compound is reported to be highly effective in the treatment of premature ventricular contraction. It has no anticholinergic or CNS activity and is not as likely as other class 1C antiarrhythmics to have restricted indications.

Originator

Suntory (Japan)

Uses

Pilsicainide hydrochloride has been used as a sodium channel blocker:

  • to study its effects on electrophysiological parameters in guinea pig pulmonary vein preparation
  • to study its effects on Ca2+?release and arrhythmic events in Andersen-Tawil syndrome induced pluripotent stem cells (ATS-iPSC)-derived cardiomyocytes
  • to study its electrophysiological effects on the guinea pig atrium

brand name

Sunrhythm

Biochem/physiol Actions

Pilsicainide hydrochloride is a pure sodium channel blocker and an open channel blocker of Na+1 channels. Pilsicainide was defined as a pure sodium channel blocker. The compound is classified as a class Ic antiarrhythmic drug, and was originally developed in Japan. Similar to Lidocaine, Pilsicainide binds to open channels, but slowly. Pilsicainide is capable of selectively blocking the late currents in the mutant Na(+) channels that show dominant abnormal burst openings such as in δKPQ mutants. The compound is used to induce Brugada syndrome (BS) in animal models.

Pilsicainide hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Pilsicainide hydrochloride Suppliers

China 84 Europe 2 India 2 Japan 1 United Kingdom 5 United States 13 Global 107
TCI Chemicals (India) Pvt. Ltd.
Tel
--
Fax
--
Email
sales-in@tcichemicals.com
Country
India
ProdList
6768
Advantage
58
A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
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View Lastest Price from Pilsicainide hydrochloride manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Pilsicainide hydrochloride 88069-49-2
Price
US $1.00-1.00/KG
Min. Order
1g
Purity
99%
Supply Ability
50tons
Release date
2020-05-11
Career Henan Chemical Co
Product
Pilsicainide hydrochloride 88069-49-2
Price
US $1.00/kg
Min. Order
1g
Purity
99%
Supply Ability
100KG
Release date
2018-12-21

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