1H-Pyrazole-1-carboxamidine hydrochloride

Product Name: 1H-Pyrazole-1-carboxamidine hydrochloride
CAS No.: 4023-02-3
Chemical Name: 1H-Pyrazole-1-carboxamidine hydrochloride
Synonyms: 1H-pyrazole-1-carboximidamide;1-AMIDINOPYRAZOLE HYDROCHLORIDE;Praxadine;1H-pyrazole-1-carboxamidine;PYRAZOLE-1-CARBOXAMIDINE;Zanamivir EP Impurity F;Pyrazole-1-carboxamidine Hydrochloride;1H-PYRAZOLE-1-CARBOXAMIDINE MONOHYDROCHLORIDE;N-GUANYLPYRAZOLE;AMIDINOPYRAZOLE HCL
CBNumber: CB9707005
Molecular Formula: C4H7ClN4
Formula Weight: 146.58
MOL File: 4023-02-3.mol

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1H-Pyrazole-1-carboxamidine hydrochloride Property

Melting point:: 167-170 °C(lit.)
storage temp.: Inert atmosphere,Room Temperature
form: Crystals or Crystalline Powder
color: White to light yellow
Water Solubility: Soluble
BRN: 5448758
InChI: InChI=1S/C4H6N4.ClH/c5-4(6)8-3-1-2-7-8;/h1-3H,(H3,5,6);1H
InChIKey: RBZRMBCLZMEYEH-UHFFFAOYSA-N
SMILES: N1(C(N)=N)C=CC=N1.[H]Cl
CAS DataBase Reference: 4023-02-3(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,C
Risk Statements: 36/37/38-36/37-34
Safety Statements: 26-37/39-45-36/37/39
WGK Germany: 3
F: 10-21
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

H318Causes serious eye damage

H335May cause respiratory irritation

H373May cause damage to organs through prolonged or repeated exposure

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P314Get medical advice/attention if you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 402516
Product name: 1H-Pyrazole-1-carboxamidine hydrochloride
Purity: 99%
Packaging: 10g
Price: $52.84
Updated: 2025/07/31

Sigma-Aldrich

Product number: Y0001703
Product name: Zanamivir impurity F
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: 10 mg
Price: $118
Updated: 2025/07/31

Sigma-Aldrich

Product number: 402516
Product name: 1H-Pyrazole-1-carboxamidine hydrochloride
Purity: 99%
Packaging: 50g
Price: $204
Updated: 2025/07/31

TCI Chemical

Product number: A2055
Product name: 1-Amidinopyrazole Hydrochloride
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $31
Updated: 2025/07/31

TCI Chemical

Product number: A2055
Product name: 1-Amidinopyrazole Hydrochloride
Purity: >98.0%(HPLC)(T)
Packaging: 25g
Price: $83
Updated: 2025/07/31

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1H-Pyrazole-1-carboxamidine hydrochloride Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystals or crystalline

Uses

1H-Pyrazole-1-carboxamidine hydrochloride may be used in the following studies: ? Preparation of guanidylated hollow fiber membranes. ? Guanylation of amines and in peptide synthesis. ? Synthesis of bis-guanidinium-cholesterol derivatives.

Uses

1H-Pyrazole-1-carboxamidine hydrochloride is a stable and versatile reagent for the efficient and chemically specific guanylation of sterically unhindered primary and secondary aliphatic amines under mild conditions. 1H-Pyrazole-1-carboxamidine hydrochloride is a useful reagent in peptide synthesis

General Description

1H-Pyrazole-1-carboxamidine hydrochloride, a pyrazole derivative, is a heterocyclic compound. It is widely used in drug syntheses studies. Pyrazole ring forms the main core of various nonsteroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs.

Synthesis

288-13-1

420-04-2

4023-02-3

Pyrazole (1.634 g, 24 mmol) and cyanamide (1 g, 24 mmol) were dissolved in 1,4-dioxane (24 mL), followed by the addition of 4 M hydrochloric acid (6 mL) to the 1,4-dioxane solution. The reaction mixture was stirred under reflux conditions for 1 hour. Upon completion of the reaction, the reaction mixture was placed in an ice-water bath and the product was induced to recrystallize by the addition of ether. The yield of the final product was 43%.

References

[1] Journal of Organic Chemistry, 1992, vol. 57, # 8, p. 2497 - 2502
[2] Organic Letters, 2004, vol. 6, # 26, p. 4925 - 4927
[3] Patent: KR101808950, 2017, B1. Location in patent: Paragraph 0233-0236
[4] Bioorganic and Medicinal Chemistry Letters, 2000, vol. 10, # 24, p. 2771 - 2774
[5] Journal of Medicinal Chemistry, 2005, vol. 48, # 3, p. 812 - 820

1H-Pyrazole-1-carboxamidine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1H-Pyrazole-1-carboxamidine hydrochloride manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 1H-Pyrazole-1-carboximidamide hydrochloride 4023-02-3
Price: US $2.20-8.80/kg
Min. Order: 1kg
Purity: 99%min
Supply Ability: 100kg
Release date: 2025-09-08

Hebei Chuanghai Biotechnology Co., Ltd

Product: 1H-Pyrazole-1-carboxamidine hydrochloride 4023-02-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-20

Henan Aochuang Chemical Co.,Ltd.

Product: 1H-Pyrazole-1-carboxamidine hydrochloride 4023-02-3
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-09-23

4023-02-3, 1H-Pyrazole-1-carboxamidine hydrochlorideRelated Search:

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