4-Fluoro-1,3-dihydro-2H-indol-2-one
- Product Name
- 4-Fluoro-1,3-dihydro-2H-indol-2-one
- CAS No.
- 138343-94-9
- Chemical Name
- 4-Fluoro-1,3-dihydro-2H-indol-2-one
- Synonyms
- 4-fluoro-1H-indol-2-ol;4-Fluorooxindole;4-FLUOROINDOLIN-2-ONE;4-fluoroindoline-2-one;4-Fluoro-2-oxindole97%;4-Fluoro-2H-indol-2-one;1H-indol-4-yl hypofluorite;4-Fluoro-1,3-dihydro-indol-2-one;4-Fluoro-2,3-dihydro-1H-indol-2-one;4-FLUORO-1,3-DIHYDRO-2H-INDOL-2-ONE
- CBNumber
- CB9711657
- Molecular Formula
- C8H6FNO
- Formula Weight
- 151.14
- MOL File
- 138343-94-9.mol
4-Fluoro-1,3-dihydro-2H-indol-2-one Property
- Boiling point:
- 297.2±40.0 °C(Predicted)
- Density
- 1.311±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 13.08±0.20(Predicted)
- form
- powder
- color
- Faint creamy orange
- InChI
- InChI=1S/C8H6FNO/c9-6-2-1-3-7-5(6)4-8(11)10-7/h1-3H,4H2,(H,10,11)
- InChIKey
- WKDSLMNPSVQOES-UHFFFAOYSA-N
- SMILES
- N1C2=C(C(F)=CC=C2)CC1=O
Safety
- Hazard Codes
- Xi
- HS Code
- 2933790090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- F595008
- Product name
- 4-Fluorooxindole
- Packaging
- 250mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- F595008
- Product name
- 4-Fluorooxindole
- Packaging
- 1g
- Price
- $175
- Updated
- 2021/12/16
- Product number
- PC8677
- Product name
- 4-Fluoro-2-oxindole
- Purity
- 97%
- Packaging
- 5g
- Price
- $222
- Updated
- 2021/12/16
- Product number
- 4H48-3-22
- Product name
- 4-Fluoro-2-oxindole
- Purity
- 97%
- Packaging
- 5G
- Price
- $356
- Updated
- 2021/12/16
- Product number
- PC8677
- Product name
- 4-Fluoro-2-oxindole
- Purity
- 97%
- Packaging
- 10g
- Price
- $370
- Updated
- 2021/12/16
4-Fluoro-1,3-dihydro-2H-indol-2-one Chemical Properties,Usage,Production
Synthesis
136916-19-3
138343-94-9
General procedure for the synthesis of 4-fluoroindol-2-one from 2-fluoro-6-nitrophenylacetic acid: (2-fluoro-6-nitrophenyl)acetic acid (3.3 g, 16.6 mmol) was dissolved in acetic acid (20 mL) and the hydrogenation reaction was carried out for 24 hours using a 10% palladium-carbon catalyst (0.5 g) under 50 psi hydrogen pressure. Upon completion of the reaction, the catalyst was filtered through Celite to remove the catalyst. The filter cake was washed with methanol and the organic phases were combined and concentrated by evaporation. Subsequently, the concentrate was dissolved in ethanol (100 mL), p-toluenesulfonic acid (50 mg) was added and heated to reflux for 1 hour. At the end of the reaction, the mixture was poured into water and extracted with ethyl acetate, and the organic phase was dried over magnesium sulfate and concentrated by evaporation. Finally, the resulting solid was ground with hexane/ethyl acetate (95/5) mixed solvent to afford 4-fluoro-1,3-dihydro-2H-indol-2-one 1.7 g in 67% yield.
References
[1] Journal of Medicinal Chemistry, 2008, vol. 51, # 6, p. 1861 - 1873
[2] Patent: US2006/9509, 2006, A1. Location in patent: Page/Page column 10
4-Fluoro-1,3-dihydro-2H-indol-2-one Preparation Products And Raw materials
Raw materials
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View Lastest Price from 4-Fluoro-1,3-dihydro-2H-indol-2-one manufacturers
- Product
- 4-Fluorooxindole; 4-fluoroindolin-2-one; 4-Fluoro-1,3-dihydro-2H-indol-2-one in stock Factory 138343-94-9
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- High quality purified Factory in China
- Supply Ability
- Top 3 production capacity Factory
- Release date
- 2019-04-03