Simvastatin

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Lipid-lowering drugs Indications Chemical properties Uses Production methods Category Toxicity grading Acute toxicity Flammability hazard characteristics Storage characteristics Extinguishing agent

Product Name: Simvastatin
CAS No.: 79902-63-9
Chemical Name: Simvastatin
Synonyms: ZOCOR;mk-0733;2,2-Dimethylbutanoic acid (1S)-1,2,3,7,8,8aα-hexahydro-3β,7α-dimethyl-8α-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]naphthalen-1β-yl ester;Denan;Eucor;Lipex;MK-733;Rechol;Simcor;Zocord
CBNumber: CB9716324
Molecular Formula: C25H38O5
Formula Weight: 418.57
MOL File: 79902-63-9.mol

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Simvastatin Property

Melting point:: 127-132 °C (lit.)
alpha: D25 +292° (c = 0.5% in acetonitrile)
Boiling point:: 564.9±50.0 °C(Predicted)
Density: 1.11±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: ≥20mg/mL
pka: 13.49±0.40(Predicted)
form: solid
color: white
optical activity: [α]/D +275±25°, c = 1 in acetonitrile
Merck: 14,8539
BCS Class: 2
Stability:: Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
CAS DataBase Reference: 79902-63-9(CAS DataBase Reference)
NIST Chemistry Reference: Simvastatin(79902-63-9)
EPA Substance Registry System: Butanoic acid, 2,2-dimethyl-, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester (79902-63-9)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-24/25
WGK Germany: 2
RTECS: EK7798000
HS Code: 29322090
Hazardous Substances Data: 79902-63-9(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: BP739
Product name: Simvastatin
Purity: British Pharmacopoeia (BP) Reference Standard
Packaging: 100MG
Price: $227
Updated: 2024/03/01

Sigma-Aldrich

Product number: 38956
Product name: Simvastatin
Purity: analytical standard
Packaging: 10mg
Price: $132
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1612700
Product name: Simvastatin
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 200mg
Price: $436
Updated: 2024/03/01

TCI Chemical

Product number: S0509
Product name: Simvastatin
Purity: >97.0%(HPLC)
Packaging: 100mg
Price: $58
Updated: 2024/03/01

TCI Chemical

Product number: S0509
Product name: Simvastatin
Purity: >97.0%(HPLC)
Packaging: 1g
Price: $345
Updated: 2024/03/01

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Simvastatin Chemical Properties,Usage,Production

Lipid-lowering drugs

Simvastatin is a cholesterol-lowering drug of statin, is a synthetic derivative of Aspergillus terreus fermentation product, is used to control blood cholesterol levels and prevent cardiovascular disease.
Simvastatin belongs to methyl hydroxyl coenzyme A (HMG-COA) reductase inhibitors, inhibits synthesis of endogenous cholesterol, and is the lipid regulator. Has a role in reducing cholesterol (TC) content of serum, liver and aorta in hyperlipidemia rabbits reducing levels of very low density lipoprotein cholesterol (VLDL-C) and low-density lipoprotein cholesterol (LDL-C).

Indications

1. Hyperlipidemia:
(1) For patients with primary hypercholesterolemia, heterozygous familial hypercholesterolemia or mixed hypercholesterolemia, when diet and other non-drug treatment is not ideal, Simvastatin can be used to reduce the increased total cholesterol, LDL cholesterol, apolipoprotein B and triglycerides. And Simvastatin increases high-density lipoprotein cholesterol, thereby reducing the LDL/HDL and total cholesterol/HDL ratio.
(2) For patients with homozygous familial hypercholesterolemia, when diet and non-diet is not ideal, Simvastatin can be used to reduce elevated total cholesterol, LDL cholesterol and apolipoprotein B.
2. Coronary heart disease:
Coronary heart disease, Simvastatin can be used to:
(1) reduce the risk of death.
(2) reduce risk of coronary heart disease death and nonfatal myocardial infarction.
(3) reduce risk of stroke and transient ischemic.
(4) reduce risk of myocardial revascularization (coronary artery bypass grafting and percutaneous coronary balloon angioplasty).
(5) delay the progression of atherosclerosis in the arteries, including the all-new lesions and the occurrence of full clogging.
The above information is edited by the chemicalbook of Liu Yujie.

Chemical properties

White crystalline powder, odorless. Soluble in ethanol, acetone or acetonitrile, difficult soluble in ether, practically insoluble in water. Melting point is 135~138 ℃.

Uses

1. HMG-CoA reductase inhibitors, can reduce the concentration of serum total cholesterol level, inhibit synthesis of cholesterol. For treatment of primary hypercholesterolemia with cholesterol levels greater than 7.8mmol/L which is invalid or not tolerated in other treatments.
2. Has role in reducing cholesterol, low-density lipoprotein cholesterol and very low density lipoprotein cholesterol.

Production methods

Lovastatin (I, 50.30 g, 0.124 mol) and n-butylamine (42 ml, 0.42 mo1), at 25 ℃: mixed, then heated at 80 ℃ for 1h. Cooled at 25 ℃, evaporated excess butylamine under reduced pressure to give 59.4g compound (Ⅱ), yield was 100%, wass used directly for the next step.
Crude product of above obtained compound (Ⅱ), is dissolved in 132 ml of dimethylformamide at 25 ℃, added imidazole (19.59 g, 0.288 mol) and tert-butyldimethylsilyl chloride (TBSCl, 44.4 g, 0.288 mol) , heated at 60 ℃ for 60 h. Cooled to 12 ℃, added anhydrous methanol (5.8 ml, 0.143 mol), stirred at 15 ℃ for 30min, added 1.5 L cyclohexane and 750 ml 5% sodium bicarbonate solution and stirred vigorously. Stratified, cyclohexane layer was separated, washed with 750ml 5% sodium bicarbonate solution and 750ml water. Concentrated to 580ml at atmospheric pressure, then add 600ml of tetrahydrofuran dried by molecular sieve, and then concentrated to 870 ml under atmosphere pressure. 86.9 g compound (Ⅲ) showed in HPLC, yield was 99%, was used directly for the next reaction.
Pyrrolidine (25.1ml, 0.301 mol)dried by molecular sieve was mixed with 192 ml of tetrahydrofuran, cooled to-18 ℃, added n-butyl lithium in hexane solution (1.60 mol/L, 181 ml, 0.290 mol), maintained at-10 ℃ about 15min addition was completed, then further reacted at-20 ℃ for 15 min. Thus obtained pyrrolidinyl lithium solution, cooled to-20 ℃ for use. The etrahydrofuran-cyclohexane solution of above obtained compound (Ⅲ) was cooled to-35 ℃, under vigorous stirring, added pyrrolidinyl lithium solution cooled to-20 ℃, maintained at-30 ℃. Addition was completed, stirred at-35 ~-30 ℃ for 2h, then added iodomethane all at once (12.2 ml, 0.196 mol), due to the exothermic reaction at this time, the temperature will rise to 20 ℃, then cooled to-30 ℃, and stirred at this temperature for 1 h. Rose to-10 ℃, stirred for 20 min. added 550ml of water, stirred vigorously for 10min, the organic layer was separated, washed with 550 ml 10 ℃ of 1 mol/L hydrochloric acid. Concentrated to 20% volume under reduced pressure, which contained the compound (Ⅳ), was used directly for the next reaction.
Added 690ml of methanol into the above obtained compound (Ⅳ), added 45.7 ml of water and methanesulfonic acid (1.5 ml, 0.023 mol), stirred at 30 ℃ for 5 h, i.e. formed compound ( V), was used directly for the next step reaction.
For a solution of above obtained compound (V) , at 25 ℃ 373 ml 2 mol/L sodium hydroxide solution was added, heated at atmospheric pressure, and subjected to distillation, when the temperature of gas phase reached 72~73 ℃, the liquid temperature reached 78~80 ℃, no longer collected distilled distillate. The remaining solution was stirred at reflux for 2h, then cooled to 40 ℃. Most of the methanol was distilled off under reduced pressure, then add 228ml water to dilute. Cooled to 10 ℃, adjusted with 3 mol L/HCl PH = 6~7. And 990 ml of ethyl acetate was added, continued to adjust PH = 5.0 with 3mol/L hydrochloric acid. After stirred to stratify, the ethyl acetate layer was separated, 225 ml of methanol was added. In 1 h, added 75 ml ammonia-methanol: solution (1:3), and then stirred at 45 ℃ for 15 min. In 2.5 h, slowly cooled to-10 ℃, and at-10 ℃ stirred for 1~2 h. Filtered ammonia salts (Ⅵ) crystals, washed with cold ethyl acetate-methanol (3.5:1), at 35 ℃ dried overnight to give 51.37 g ammonia salts (Ⅵ), a yield was 90.9% (calculated by lovastatin). Recrystallized with acetonitrile to obtain a sample for analysis.
The crude product of ammonium salt (Ⅵ) was suspended in 1.03 L toluene, inlet nitrogen, heated at 100 ℃ for 6 h. Cooled to 25 ℃, added 2.5 g Darco KB, stirred at 25 ℃ for 30 min. Filtered and the filtrate was concentrated to grease under reduced pressure, added 140 ml of cyclohexane and concentrated. Then add 600ml of cyclohexane, reflux and completely dissolved. Cooled to 10 ℃, stirred for 1 h. Filtered and collected crystals, washed with 25 0ml of cold cyclohexane, dried at 30~35 ℃ under vacuum to give 44.6 g Simvastatin, yield was 94.2%. Recrystallized with methanol-water to give a sample for analysis.

Toxicity grading

Poisoning

Acute toxicity

Oral-rat LD50: 4438 mg/kg; Oral-mouse LD50: 3000 mg /kg.

Flammability hazard characteristics

Combustible; fire releases spicy smoke.

Storage characteristics

Treasury is low temperature, ventilation, dry; in dark.

Extinguishing agent

Water, carbon dioxide, dry, sandy soil.

Description

Simvastatin is an once-daily hypolipemic, an analog of lovastatin indicated for the treatment of atherosclerosis. In patients with Type IN or IIB hypercholesterolemia, simvastatin reportedly produces significant reductions in total serum cholesterol, LDL, mglycerides and apolipoprotein-B, while HDL and apolipoprotein-A levels are increased.

Chemical Properties

White Powder

Originator

Merck (USA)

Uses

A HMGCR inhibitor and anti-proliferative agent.

Uses

Simvastatin is a synthetic derivate of a fermentation product of Aspergillus terreus. A competitive inhibitor of HMG-CoA reductase. A synthetic analog of Lovastatin. Antilipemic. Simvastatin, the drug, is sold under the trade name Zocor.

Uses

antiinflammatory

Uses

Simvastatin is a synthetic derivative of a fermentation product of Aspergillus terreus. A competitive inhibitor of HMG-CoA reductase. A synthetic analog of Lovastatin. Antilipemic. Simvastatin, the dr ug, is sold under the trade name Zocor.

Uses

Simvastatin is semi-synthetic, slightly more hydrophobic, analogue of lovastatin. Like lovastatin, simvastatin is a specific inhibitor of HMG-CoA reductase and is used therapeutically to reduce LDL cholesterol. More recently, the statins have become important biochemical probes in cell biology. Their involvement in many events can be correlated to their primary mode of action, however, the mechanism of action of many other effects is less apparent.

Uses

anti-hyperlipoproteinemic, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor

Definition

ChEBI: A carbobicyclic compound that is lovastatin in which the 2-methylbutyrate ester moiety has been replaced by a 2,2-dimethylbutyrate ester group. It is used as a cholesterol-lowering and anti-cardiovascular disease drug.

Manufacturing Process

A suspension of Lovastatin (350 g, 0.865 mmol), phenylboronic acid (110.8 g, 0.909 mmol) and toluene (1.75 L) was heated under a nitrogen atmosphere at 100-105°C for 55 min. The water was separated from the reaction mixture. The solution was cooled and 1.39 L of toluene was removed by vacuum distillation at 40-50°C. The concentrated solution was treated with hexanes (3.15 L) at 40-50°C. The resulting suspension was cooled to 0-5C for 2 hours and the product was filtered and washed with hexanes (350 mL). The product was dried at 35-40°C under vacuum to provide 427.9 g (37%) of lovastatin phenylboronate at >99% purity by HPLC.
A 2 L 3-necked flask was charged with pyrrolidine (56 mL, 0.67 mol) and dry THF (453 g) under a nitrogen atmosphere. n-Butyl lithium (419 mL, 1.6 M hexane solution, 0.67 mol) was added dropwise at -20°C over a period of 1 hour. The solution was maintained at this temperature for 30 min and then cooled to -55°C. A solution of lovastatin phenylboronate (101.7 g, 0.20 mol) in 274.7 g of THF was cooled to -50°C and then added to the cold lithium pyrrolidide solution at a rate such that the internal temperature was between -50°-55°C during the addition. The mixture was held at this temperature for 4 hours and then methyl iodide (116.4 g, 0.82 mol) was added at a temperature below -55°C. The reaction was stirred for 13 hours at -20°C and then quenched with 500 mL of 2 M HCl at a temperature below 0°C. After warming to 20°C, the layers were separated and the aqueous layer was extracted with ethyl acetate. The combined organic layers were washed with 5% NaHSO3 solution and deionized water. The solution was filtered through a Celite pad and concentrated to yield 102.8 g (98.4%) of crude Simvastatin phenylboronate at >95% purity by HPLC. A portion of the above material (50.0 g) was charged into a nitrogen purged flask with acetonitrile (100 mL). The suspension was heated at 110°C for 3 hours and then cooled to - 10°C for 1 hour. The product was filtered and washed with 25 mL of acetonitrile and dried under vacuum to provide 43.7 g of Simvastatin phenylboronate at >99% purity by HPLC.
A suspension of simvastatin phenylboronate (30.0 g) and 1,3-propanediol (450 mL) was heated at 105-107°C at 0.2 mm Hg. After 1 hour, 182 mL of distillate was collected and the reaction was cooled to 20-25°C. Deionized water (270 mL) was added and toluene (3 times 75 mL) was used to extract the mixture. The combined toluene layers were washed with water (60 mL). The organic solution was heated at reflux for 1 hour and water was azeotropically removed. The solution was concentrated to a final volume of 24 mL under vacuum at 48-50°C. To the concentrated solution was added hexanes (215 mL) over 10 min. The resulting slurry was cooled to 0-5°C and filtered. The crude Simvastatin was washed at 0-5°C with hexanes and dried under vacuum to yield 21.0 g (88%) of Simvastatin.

brand name

Zocor (Merck);Zocord.

Therapeutic Function

Antihyperlipidemic

General Description

Simvastatin, 2,2-dimethyl butanoic acid,1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2-pyran-2-yl)ethyl]-1-naphthalenyl ester(Zocor), is an analog of lovastatin. These two drugs havemany similar properties. Both drugs, in the prodrug form,reach the liver unchanged after oral administration, wherethey undergo extensive metabolism to several open-ring hydroxyacids, including the active -hydroxy acids. They arealso highly bound to plasma proteins. These actions makethe bioavailability of simvastatin rather poor but better thanthat of lovastatin, which has been estimated to be 5%.

Biological Activity

HMG-CoA reductase inhibitor; decreases levels of low density lipoprotein. Has multiple biological effects including bone formation stimulation, inhibition of smooth muscle cell proliferation and migration, and anticancer and anti-inflammatory activity.

Biochem/physiol Actions

Simvastatin is a specific inhibitor of HMG-CoA reductase, the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. It is used in the treatment of hypercholesterolemia, as it reduces levels of low-density lipoproteins and triglycerides, and raises high-density lipoprotein levels. Simvastatin is a lactone that is readily hydrolyzed in vivo to the corresponding β-hydroxyacid, and can be activated prior to use with NaOH in EtOH treatment. It is a synthetic analog of lovastatin (Cat. No. M2147).

Clinical Use

HMG CoA reductase inhibitor:
Primary hypercholesterolaemia

target

Drug interactions

Potentially hazardous interactions with other drugs
Anti-arrhythmics: increased risk of myopathy with amiodarone - do not exceed 20 mg of simvastatin1 ; increased risk of myopathy with dronedarone.
Antibacterials: increased risk of myopathy with clarithromycin, daptomycin, erythromycin and fusidic acid - avoid; possibly increased myopathy with azithromycin; concentration possibly reduced by rifampicin.
Anticoagulants: effects of coumarins enhanced.
Antiepileptics: concentration reduced by carbamazepine and eslicarbazepine.
Antifungals: increased risk of myopathy with fluconazole, itraconazole, posaconazole, ketoconazole, voriconazole and possibly miconazole - avoid; possibly increased risk of myopathy with imidazoles.
Antivirals: increased risk of myopathy with atazanavir, indinavir, lopinavir, ritonavir or saquinavir and possibly fosamprenavir, lopinavir or tipranavir - avoid; concentration reduced by efavirenz; avoid with boceprevir, dasabuvir, ombitasvir, paritaprevir and telaprevir; possible increased risk of myopathy with ledipasvir - reduce simvastatin dose; concentration increased by simeprevir - consider reducing simvastatin dose.
Calcium-channel blockers: increased risk of myopathy with verapamil, diltiazem and amlodipine - do not exceed 20 mg of simvastatin.1
Ciclosporin: increased risk of myopathy - avoid.1
Cobicistat: avoid with simvastatin.
Colchicine: possible increased risk of myopathy.
Grapefruit: increased risk of myopathy - avoid.
Hormone antagonists: possibly increased risk of myopathy with danazol - avoid.1
Lipid-lowering agents: increased risk of myopathy with fibrates - do not exceed 10 mg of simvastatin except with fenofibrate1 ; gemfibrozil - avoid; concentration increased by lomitapide - do not exceed 40 mg of simvastatin; increased risk of myopathy with nicotinic acid.
Ranolazine: concentration increased by ranolazine, maximum dose of simvastatin is 20 mg.
Ticagrelor: concentration of simvastatin increased; maximum dose of simvastatin is 40 mg

Metabolism

Simvastatin is absorbed from the gastrointestinal tract and must be hydrolysed to its active β-hydroxyacid form. Other active metabolites have been detected and several inactive metabolites are also formed. Simvastatin is a substrate for the cytochrome P450 isoenzyme CYP3A4 and undergoes extensive first-pass metabolism in the liver, its primary site of action. Less than 5% of an oral dose has been reported to reach the circulation as active metabolites.
Simvastatin is mainly excreted in the faeces via the bile as metabolites. About 10-15% is recovered in the urine, mainly in inactive forms.

storage

Desiccate at -20°C

References

References/Citations 1) Merck 14:8539 2) Hancock et al. (1989), All ras proteins are polyisoprenylated but only some are palmitoylated; Cell, 57 1167 3) Ose et al. (2000), Lipid-altering efficacy and safety of simvastatin 80 mg/day: long-term experience in a large group of patients with hypercholesterolemia. World Wide Expanded Dose Simvastatin Study Group Clin. Cardiol. 23 39 4) Matsuzaka et al. (2016) Characterization and functional analysis of extracellular vesicles and muscle-abundant miRNA in C2C12 myocytes and Mdx mice; PLoS One 11(12) e0167811 [Focus Biomolecules Citation]

Simvastatin Preparation Products And Raw materials

Raw materials

N,N-Dimethylformamide tert-Butyldimethylsilyl chloride Cyclohexane Butylamine Lovastatin Methanol Lithium alkyls Iodomethane n-Butyllithium Pyrrolidine

Preparation Products

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View Lastest Price from Simvastatin manufacturers

HUARONG(GUANGDONG) PHARMACEUTICAL CO.,LTD

Product: Simvastatin 79902-63-9
Price: US $0.00/kg
Min. Order: 25kg
Purity: 99% IP/EP/USP
Supply Ability: 100000
Release date: 2024-11-08

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Simvastatin 79902-63-9
Price: US $0.00-0.00/Kg/Drum
Min. Order: 1KG
Purity: 98%-101%;USP
Supply Ability: 500 KG
Release date: 2021-06-03

Nanjing Fred Technology Co., Ltd

Product: Simvastatin 79902-63-9
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%, Single impurity＜0.1
Supply Ability: 1 ton
Release date: 2024-01-04

79902-63-9, SimvastatinRelated Search:

Dimethyl phthalate Dimethyl ether Poly(dimethylsiloxane) Dimethyl sulfone Dimethyl sulfoxide N,N-Dimethylaniline Dimethyl fumarate Dichlorodimethylsilane N,N-Dimethylformamide N,N-Dimethylacetamide ETHANE Dimethyl sulfide Cinchonine Cinchonidine ACETYLSIMVASTATIN SIMVASTATIN HYDROXY ACID, AMMONIUM SALT,SIMVASTATIN AMMONIUM SALT Simvastatin Hydroxy Acid Methyl Ester SiMvastatinAcetate Ester

(1s-(1-alpha,3-dro-4-hydroxy-6-oxo-2h-pyran-2-yl)ethyl)-1-naphthalenyleste

7-beta,8-beta(2s*,4s*),8a-beta))-alph

[1S-[1α，3α，7β，8β(2S^<*>^，4S^<*>^)，8αβ]-2，2-Dimethylbutanoic acid 1，2，3，7，8，8α-hexahydro-3，7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-y1)ethyl]-1-naphthyl ester

Lodaiès

[(1S,3R,7R,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxo-oxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoat

Butanoic acid, 2,2-dimethyl-, 1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(tetrahydro- 4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester, (1S-(1-alpha,3-alpha,7- beta,8-beta(2S*,4S*),8a-beta))

[8-[2-(4-Hydroxy-6-oxo-tetrahydropyran-2-yl)ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl]2,2-dimethylbutanoate

2,2-Dimethylbutanoic acid (1S)-1,2,3,7,8,8aα-hexahydro-3β,7α-dimethyl-8α-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]naphthalen-1β-yl ester

2,2-Dimethylbutyric acid (1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalene-1-yl ester

(1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyly-2,2-dimethylbutanoate

LIPONORM

MK-733

SIMVASTATIN

SYNVINOLIN

(1S,3R,7S,8S,8AR)-1,2,3,7,8,8A-HEXAHYDRO-3,7-DIMETHYL-8-[2-[(2R,4R)-TETRAHYDRO-4-HYDROXY-6-OXO-2H-PYRAN-2-YL]ETHYL]-1-NAPHTHALENYLY-2,2-DIMETHYL BUTANOATE

2,2-DIMETHYL-BUTYRIC ACID (1S,3R,7S,8S,8AR)-8-[2-((2R,4R)-4-HYDROXY-6-OXO-TETRAHYDRO-PYRAN-2-YL)-ETHYL]-3,7-DIMETHYL-1,2,3,7,8,8A-HEXAHYDRO-NAPHTHALEN-1-YL ESTER

2,2-DIMETHYLBUTANOIC ACID 1,2,3,7,8,8A-HEXAHYDRO-3,7-DIMETHYL-8-[2-TETRAHYDRO-4-HYDROXY-2-OXO-2H-PYRAN-YL]-1-NAPHTHALENYL ESTER

Simvastatin (200 mg)

Simvastatin (200 mg)I0D3820.994mg/mg(ai)

SiMvastatin (COS)

(1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl}-3,7-diMethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-diMethylbutanoate

6'-exoMethylene SiMvastatin, Acid SodiuM Salt

SiMvastatin (EP/BP)

SiMvastatin API

Simvastatin Solution, 1000ppm

ZOCOR

SIMVASTATIN USP24

Simvastatin USP23,24

SimvastatinC25H3805

SimvastatineUsp25

Simvastatin MK 733 Zorced

Simvastatin, 97%, inhibitor of HMG-CoA reductase

Simvastatin - CAS 79902-63-9 - Calbiochem

8-[2-(4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydro-1-naphthalenyl 2,2-dimethylbutanoate

butanoicacid,2,2-dimethyl-,1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(tetrahy

(1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl 2,2-dimethyl-butanoate

2,2-Dimethlbutanoic acid 1,2,3,7,8,8a-hexahydro-3,7-dimethl-8-[2-tetrahyddro-4-hydroxy-2-oxo-2H-pydran-yl]-1-naphthalenyl ester

4-(tert-butyl-dimethyl-silanyloxy)-6-(2-(8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydro

Zocor, MK-733, Liponorm

Butanoic acid, 2,2-dimethyl-, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-2-(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-ylethyl-1-naphthalenyl ester

SIMVASTATIN,USP

2,2-Dimethyl-butyric acid 8-[2-(4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydro-naphthalen-1-yl ester

Butanoic acid, 2,2-dimethyl-, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester (9CI)

Butanoic acid, 2,2-dimethyl-, 1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl ester, [1S-[1a,3a,7b,8b(2S*,4S*),8ab]]-

Cholestat

Denan

Eucor

Kolestevan

Lipex

Lipinorm

Lipovas

Lodales

Modutrol

Nor-Vastina

Rechol

Simcor

Simovil

Simvotin