ChemicalBook > CAS DataBase List > AROTINOLOL HCL

AROTINOLOL HCL

Product Name
AROTINOLOL HCL
CAS No.
68377-91-3
Chemical Name
AROTINOLOL HCL
Synonyms
ARL;s596;Almarl;Acemail;Astonil;Anasirol;thiazolehcl;AROTINOLOL HCL;AROTINOLOL HYDROCHLORIDE;AROTINOLOL HCL USP/EP/BP
CBNumber
CB9723043
Molecular Formula
C15H22ClN3O2S3
Formula Weight
408
MOL File
68377-91-3.mol
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AROTINOLOL HCL Property

Melting point:
234-235.5° (dec)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
Water Solubility 
Practically insoluble in water
form 
powder to crystal
color 
White to Orange to Green
Merck 
14,791
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Safety

RIDADR 
UN 2811 6.1/PG III
RTECS 
XM8301000
HS Code 
2934.99.3000
HazardClass 
6.1
PackingGroup 
III
Toxicity
LD50 in mice (mg/kg): 86 i.v., >360 i.p., >5000 orally (Hara)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
A3145
Product name
Arotinolol Hydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
50mg
Price
$126
Updated
2024/03/01
TCI Chemical
Product number
A3145
Product name
Arotinolol Hydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
250mg
Price
$402
Updated
2021/12/16
TRC
Product number
A771503
Product name
Arotinolol Hydrochloride
Packaging
10mg
Price
$1135
Updated
2021/12/16
Chem-Impex
Product number
37622
Product name
Arotinololhydrochloride,98%(HPLC)
Purity
98%(HPLC)
Packaging
250MG
Price
$445.76
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0016528
Product name
AROTINOLOL HYDROCHLORIDE
Purity
95.00%
Packaging
5MG
Price
$496.2
Updated
2021/12/16
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AROTINOLOL HCL Chemical Properties,Usage,Production

Description

Arotinolol hydrochloride i s a β-adrenergic blocker with weak α-antagonistic properties, useful in the treatment of hypertension.

Originator

Sumitomo (Japan)

Uses

Arotinolol is both and alpha- and beta-adrenoceptor antagonist and is used to treat essential tremors and hypertension.

Definition

ChEBI: Arotinolol hydrochloride is an aromatic amide and a member of thiophenes.

Manufacturing Process

To a solution of 2-mercapto-4-(5'-carbamoyl-2'-thiophenyl)thiazole, 3.2 g in 20 ml of 0.3 % aqueous sodium hydroxide solution, 1-chloro-3-tbutylaminopropanol, 12.64 g in 20 ml of methanol was added, while the temperature was maintained at 20°C.
The reaction solution was stirred at room temperature for 4 h, and then condensed to a half volume in vacuo. The residual solution, added with 100 ml of water, was extracted with chloroform. The chloroform extract was washed with water, dried over anhydrous magnesium sulfate and evaporated in vacuo to give 4.8 g of 2-(3'-t-butylamino-2'-hydroxypropylthio)-4-(5'-carbamoyl-2'- thiophenyl)thiazole, as crystals, melting point 234°-235.5°C (dec., recrystallized from methanol/water).
In practice it is usually used as hydrochloride.

brand name

ALMARL

Therapeutic Function

Beta-adrenergic blocker

AROTINOLOL HCL Preparation Products And Raw materials

Raw materials

Preparation Products

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AROTINOLOL HCL Suppliers

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View Lastest Price from AROTINOLOL HCL manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
AROTINOLOL HCL 68377-91-3
Price
US $1.00-1.00/KG
Min. Order
1g
Purity
99%
Supply Ability
50tons
Release date
2020-05-11
Shaanxi TNJONE Pharmaceutical Co., Ltd
Product
Arotinolol Hydrochloride 68377-91-3
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000kg
Release date
2024-04-24
Career Henan Chemical Co
Product
AROTINOLOL HCL 68377-91-3
Price
US $1.00/KG
Min. Order
1G
Purity
98%
Supply Ability
100KG
Release date
2018-08-20

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