ChemicalBook > CAS DataBase List > AROTINOLOL HCL

AROTINOLOL HCL

Product Name
AROTINOLOL HCL
CAS No.
68377-91-3
Chemical Name
AROTINOLOL HCL
Synonyms
ARL;s596;Almarl;Acemail;Astonil;Anasirol;thiazolehcl;AROTINOLOL HCL;AROTINOLOL HYDROCHLORIDE;AROTINOLOL HCL USP/EP/BP
CBNumber
CB9723043
Molecular Formula
C15H22ClN3O2S3
Formula Weight
408
MOL File
68377-91-3.mol
More
Less

AROTINOLOL HCL Property

Melting point:
234-235.5° (dec)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
Water Solubility 
Practically insoluble in water
form 
powder to crystal
color 
White to Orange to Green
Merck 
14,791
More
Less

Safety

RIDADR 
UN 2811 6.1/PG III
RTECS 
XM8301000
HS Code 
2934.99.3000
HazardClass 
6.1
PackingGroup 
III
Toxicity
LD50 in mice (mg/kg): 86 i.v., >360 i.p., >5000 orally (Hara)
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

TCI Chemical
Product number
A3145
Product name
Arotinolol Hydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
50mg
Price
$126
Updated
2024/03/01
TCI Chemical
Product number
A3145
Product name
Arotinolol Hydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
250mg
Price
$402
Updated
2021/12/16
TRC
Product number
A771503
Product name
Arotinolol Hydrochloride
Packaging
10mg
Price
$1135
Updated
2021/12/16
Chem-Impex
Product number
37622
Product name
Arotinololhydrochloride,98%(HPLC)
Purity
98%(HPLC)
Packaging
250MG
Price
$445.76
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0016528
Product name
AROTINOLOL HYDROCHLORIDE
Purity
95.00%
Packaging
5MG
Price
$496.2
Updated
2021/12/16
More
Less

AROTINOLOL HCL Chemical Properties,Usage,Production

Description

Arotinolol hydrochloride i s a β-adrenergic blocker with weak α-antagonistic properties, useful in the treatment of hypertension.

Originator

Sumitomo (Japan)

Uses

Arotinolol is both and alpha- and beta-adrenoceptor antagonist and is used to treat essential tremors and hypertension.

Definition

ChEBI: Arotinolol hydrochloride is an aromatic amide and a member of thiophenes.

Manufacturing Process

To a solution of 2-mercapto-4-(5'-carbamoyl-2'-thiophenyl)thiazole, 3.2 g in 20 ml of 0.3 % aqueous sodium hydroxide solution, 1-chloro-3-tbutylaminopropanol, 12.64 g in 20 ml of methanol was added, while the temperature was maintained at 20°C.
The reaction solution was stirred at room temperature for 4 h, and then condensed to a half volume in vacuo. The residual solution, added with 100 ml of water, was extracted with chloroform. The chloroform extract was washed with water, dried over anhydrous magnesium sulfate and evaporated in vacuo to give 4.8 g of 2-(3'-t-butylamino-2'-hydroxypropylthio)-4-(5'-carbamoyl-2'- thiophenyl)thiazole, as crystals, melting point 234°-235.5°C (dec., recrystallized from methanol/water).
In practice it is usually used as hydrochloride.

brand name

ALMARL

Therapeutic Function

Beta-adrenergic blocker

AROTINOLOL HCL Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

AROTINOLOL HCL Suppliers

Americas 1 China 93 Germany 1 India 1 United Kingdom 5 United States 13 Global 114
NANJING TOMMLAB PHARMATECH Co.,LTD
Tel
--
Fax
--
Email
litianang@caremo.com.cn
Country
China
ProdList
249
Advantage
58
Wellman Pharmaceutical Group Limited
Tel
027-027-83778875 15807197853
Fax
027-83991220
Email
15807197853@163.com
Country
China
ProdList
3979
Advantage
58
Jiangxi ravel Biotechnology Co.,Ltd
Tel
185-0276-2003 18502762003;
Email
435918333@qq.com
Country
China
ProdList
2243
Advantage
58
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
18089
Advantage
64
Hunan Hui Bai Shi Biotechnology Co., Ltd.
Tel
0731-85526065 13308475853
Email
ivy@hnhbsj.com
Country
China
ProdList
4550
Advantage
62
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
18521735133 18521732826;
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25014
Advantage
65
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3421
Advantage
58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66113011 18112977050
Email
cb6@aikonchem.com
Country
China
ProdList
16687
Advantage
50
BEIJING EAGLE SKY PHARMATECH CO., LTD
Tel
010-88755821 13911359480
Email
sophia_818@126.com
Country
China
ProdList
274
Advantage
55
Chengdu Miracle Pharmaceutical Co., Ltd.
Tel
028-86136736 19130631884
Fax
028-85265615
Email
sales@mic-pharma.com
Country
China
ProdList
276
Advantage
56
Shanghai RenYue Chemical Technology Co., Ltd.
Tel
021-62219190; 18321139117
Email
316441092@qq.com
Country
China
ProdList
1344
Advantage
55
parabiochem
Tel
025-83453382-8005
Fax
025-83453382
Email
sale@parabiochem.com
Country
China
ProdList
9604
Advantage
55
BePharm Ltd
Tel
400-685-9117
Fax
021-51816740
Email
market@bepharm.com
Country
China
ProdList
15081
Advantage
60
Shanghai SuperLan Chemcial Technique Centre
Tel
021-2022843681 15618226720
Fax
+86-21-51601218
Email
chaolaichem@foxmail.com
Country
China
ProdList
9038
Advantage
58
Hubei widely chemical technology Co., Ltd.
Tel
027-59402396 13419635609
Fax
027-83989310
Email
13419635609@163.com
Country
China
ProdList
1992
Advantage
55
Wuhan Wsem Biological Co., Ltd.
Tel
027-83778876 13667159345
Fax
027-83778876
Email
13667159345@163.com
Country
China
ProdList
1942
Advantage
55
Beijing JHYB Pharmaceutical Technology Co., Ltd
Tel
(86)-010-88593845
Fax
010-88593946
Country
China
ProdList
29
Advantage
62
Wuhan FengyaoTonghui Chemical Products Co., Ltd.
Tel
027-87466105 15377573527
Email
2678564200@qq.com
Country
China
ProdList
17997
Advantage
58
Nanjing ChemLin Chemical Industry Co., Ltd.
Tel
025-83453353
Fax
025-83453353
Email
nj.chemlin@chemlin.com.cn
Country
CHINA
ProdList
853
Advantage
58
Angel Pharmatech, Ltd.
Tel
17317130613
Fax
QQ3358272972
Email
3358272972@qq.com
Country
China
ProdList
3242
Advantage
58
Shenzhen Botel Biotechnology Co. Ltd.
Tel
0755-22202135 13316968096
Email
1979313431@qq.com
Country
China
ProdList
7787
Advantage
58
TCI Chemicals
Tel
021-67121386, 800-988-0390
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
5391
Advantage
58
Hefei TNJ Chemical Industry Co.,Ltd.
Tel
0551-65418684 +8618949823763
Fax
0086-551-65418684
Email
sales@tnjchem.com
Country
China
ProdList
25363
Advantage
58
Dideu Industries Group Limited
Tel
+86-29-89586680 +86-15129568250
Email
1026@dideu.com
Country
China
ProdList
28557
Advantage
58
Dayang Chem (Hangzhou) Co.,Ltd.
Tel
571-88938639 +8617705817739
Fax
+86-571-88938652，+86-571- 88492614
Email
info@dycnchem.com
Country
CHINA
ProdList
52867
Advantage
58
Hefei Hirisun Pharmatech Co., Ltd
Tel
+8615056975894
Fax
86-0551-62678551
Email
shawn@hirisunpharm.com
Country
CHINA
ProdList
9923
Advantage
58
Shaanxi Dideu Medichem Co. Ltd
Tel
+86-029-89586680 +86-18192503167
Fax
+86-29-88380327
Email
1026@dideu.com
Country
China
ProdList
9126
Advantage
58
SIMAGCHEM CORP
Tel
+86-13806087780
Email
sale@simagchem.com
Country
China
ProdList
17367
Advantage
58
Chemwill Asia Co.,Ltd.
Tel
86-21-51086038
Fax
86-21-51861608
Email
chemwill_asia@126.com
Country
CHINA
ProdList
23931
Advantage
58
Rare Chemistry (Hong Kong) Co., Ltd.
Tel
Email
93634146@qq.com
Country
China
ProdList
831
Advantage
58
Shanghai Yanze Chemical Co., Ltd.
Tel
021-13773155751 19901447308
Email
260924549@qq.com
Country
China
ProdList
8696
Advantage
58
Chongqing Chemdad Co., Ltd
Tel
+86-023-61398051 +8613650506873
Email
sales@chemdad.com
Country
China
ProdList
39916
Advantage
58
Wuhan Dingtong Pharmaceutical Co., Ltd
Tel
027-027-59207795 18327179646
Fax
027-59207795
Email
18327179646@163.com
Country
China
ProdList
1984
Advantage
58
CONIER CHEM AND PHARMA LIMITED
Tel
+8618523575427
Email
sales@conier.com
Country
China
ProdList
49391
Advantage
58
Shaanxi Dideu Medichem Co. Ltd
Tel
+86-29-87569265 +86-18612256290
Fax
029-88380327
Email
1056@dideu.com
Country
China
ProdList
3335
Advantage
58
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
4008210725 4008210725
Email
malulu@leyan.com
Country
China
ProdList
55023
Advantage
58
Chongqing Kangzhou Zhitong Pharmaceutical Technology Co., Ltd.
Tel
173-08362167 17308362167
Email
3090602484@qq.com
Country
China
ProdList
568
Advantage
58
Wuhan Dingxintong Pharmaceutical Co. , Ltd.
Tel
027-027-52344656 15871722230
Fax
2796190295
Email
15871722230@163.com
Country
China
ProdList
3000
Advantage
58
Wuhan Topule
Tel
+86-02787215551 +86-19945035818
Fax
027-87215551
Email
2936752263@qq.com
Country
China
ProdList
7955
Advantage
58
Changzhou Furuisi Biotechnology Co., Ltd
Tel
0519-85524369
Email
3477467573@qq.com
Country
China
ProdList
8618
Advantage
58
Hubei Wande Chemical Co., Ltd
Tel
027-59210159 15377098680
Fax
027-59210159
Email
1148280011@qq.com
Country
China
ProdList
9994
Advantage
58
Hubei Qifei Pharmaceutical Chemical Co., Ltd
Tel
027-027-59322506 18071128681
Fax
027-59322506
Email
1438082200@qq.com
Country
China
ProdList
9995
Advantage
58
Wuhan Linglingjiu Biotechnology Co., Ltd
Tel
15623309010
Email
1287744812@qq.com
Country
China
ProdList
1657
Advantage
58
Wuhan Fortuna Chemical Co., Ltd
Tel
027-027-59207852 13308628970
Fax
QQ:2779667926
Email
buy@fortunachem.com
Country
China
ProdList
2640
Advantage
58
Hebei Momojin Biological Technology Co., Ltd
Tel
13315457394 13315457394
Email
june@hbmojin.com
Country
China
ProdList
2689
Advantage
58
Changzhou Xianglong Pharmaceutical Technology Co., LTD
Tel
0519-88910898 18661161657
Email
yaoxiangqiu2021@163.com
Country
China
ProdList
10066
Advantage
58
Jiangxi ravel Biotechnology Co.,Ltd
Tel
13184580281
Fax
400-880-2824
Email
hj@ruiweier.cn
Country
China
ProdList
2103
Advantage
58
Jiangxi ravel Biotechnology Co.,Ltd
Tel
18502762009
Email
721846333@qq.com
Country
China
ProdList
2446
Advantage
58
Hubei Kele Fine Chemical Co., Ltd
Tel
027-59101668 19945030958
Fax
027-59101668
Email
2881924765@qq.com
Country
China
ProdList
7977
Advantage
58
Wuhan Augda Biotechnology Co., Ltd
Tel
15071299552
Fax
QQ:262933239
Email
262933239@qq.com
Country
China
ProdList
6637
Advantage
58
More
Less

View Lastest Price from AROTINOLOL HCL manufacturers

Shaanxi TNJONE Pharmaceutical Co., Ltd
Product
Arotinolol Hydrochloride 68377-91-3
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000kg
Release date
2024-04-24
Shaanxi Dideu Medichem Co. Ltd
Product
AROTINOLOL HCL 68377-91-3
Price
US $1.00-1.00/KG
Min. Order
1g
Purity
99%
Supply Ability
50tons
Release date
2020-05-11
Dideu Industries Group Limited
Product
AROTINOLOL HCL 68377-91-3
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-08-11

68377-91-3, AROTINOLOL HCLRelated Search:

NADOLOL Methimazole Benzenesulfonic acid Fluvastatin sodium salt Alprenolol Olmesartan Medoxomil AROTINOLOL AROTINOLOL HCL Almagate 5-(2-sulfanylidene-3H-1,3-thiazol-4-yl)thiophene-2-carboxamide 4-METHYLTHIAZOLE-2-THIOL 2-(Aminomethyl)-5-methylthiophene hydrochloride

  • thiazolehcl
  • 2-Thiophenecarboxamide, 5-[2-[[3-[(1,1-dimethylethyl)amino]-2-hydroxypropyl]thio]-4-thiazolyl]-, monohydrochloride
  • 2-Thiophenecarboxamide, 5-[2-[[3-[(1,1-dimethylethyl)amino]-2-hydroxypropyl]thio]-4-thiazolyl]-, monohydrochloride, (+-)-
  • Almarl
  • ARL
  • (+-)-2-(3'-tert-Butylamino-2'-hydroxypropylthio)-4-(5'-carbamoyl-2'-thienyl)thiazole HCl
  • Acemail
  • Anasirol
  • Astonil
  • 5-(2-(3-(tert-butylamino)-2-hydroxypropylthio)thiazol-4-yl)thiophene-2-carboxamide hydrochloride
  • AROTINOLOL HCL###arotinolol
  • AROTINOLOL HCL
  • AROTINOLOL HYDROCHLORIDE
  • (+-)-2-(3’-tert-butylamino-2’-hydroxypropylthio)-4-(5’-carbamoyl-2’-thienyl)
  • 2-thiophenecarboxamide,5-(2-((3-((1,1-dimethylethyl)amino)-2-hydroxypropyl)thi
  • monohydrochloride,(+-)-o)-4-thiazolyl)
  • s596
  • 2-Thiophenecarboxamide, 5-[2-[[3-[(1,1-dimethylethyl)amino]-2-hydroxypropyl]thio]-4-thiazolyl]-, hydrochloride (1:1)
  • AROTINOLOL HCL USP/EP/BP
  • 68377-91-3
  • C15H21N3O2S3HCl
  • C15H22ClN3O2S3
  • API