ChemicalBook > CAS DataBase List > 2-Phenylindole

2-Phenylindole

Product Name
2-Phenylindole
CAS No.
948-65-2
Chemical Name
2-Phenylindole
Synonyms
2-PHENYL-1H-INDOLE;1H-Indole,2-phenyl-;NSC 15776;stabilizeri;Stabilizer I;-Phenylindole;A-PHENYLINDOL;2-PHENYLINDOLE;a-Phenylindole;2-phenyl-indol
CBNumber
CB9725557
Molecular Formula
C14H11N
Formula Weight
193.24
MOL File
948-65-2.mol
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2-Phenylindole Property

Melting point:
188-190 °C (lit.)
Boiling point:
250 °C/10 mmHg (lit.)
Density 
1.1061 (rough estimate)
refractive index 
1.5850 (estimate)
Flash point:
250°C/10mm
storage temp. 
Sealed in dry,Room Temperature
solubility 
almost transparency in Methanol
form 
Powder
pka
16.80±0.30(Predicted)
color 
Off-white to beige or slightly green
CAS DataBase Reference
948-65-2(CAS DataBase Reference)
NIST Chemistry Reference
1H-Indole, 2-phenyl-(948-65-2)
EPA Substance Registry System
1H-Indole, 2-phenyl- (948-65-2)
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Safety

Hazard Codes 
Xi
Risk Statements 
37/38-41
Safety Statements 
26-39
WGK Germany 
3
RTECS 
NM1272500
TSCA 
Yes
HS Code 
29309090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P26600
Product name
2-Phenylindole
Purity
technical grade, 95%
Packaging
100g
Price
$23.92
Updated
2024/03/01
Sigma-Aldrich
Product number
P26600
Product name
2-Phenylindole
Purity
technical grade, 95%
Packaging
5g
Price
$36.4
Updated
2024/03/01
TCI Chemical
Product number
P0188
Product name
2-Phenylindole
Purity
>98.0%(GC)
Packaging
25g
Price
$27
Updated
2024/03/01
TCI Chemical
Product number
P0188
Product name
2-Phenylindole
Purity
>98.0%(GC)
Packaging
250g
Price
$78
Updated
2024/03/01
Alfa Aesar
Product number
B23674
Product name
2-Phenylindole, 95%
Packaging
50g
Price
$27.65
Updated
2024/03/01
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2-Phenylindole Chemical Properties,Usage,Production

Chemical Properties

off-white to beige or slightly green powder

Uses

Reactant for preparation of: • ;Oxopyrrolidine analogs via iodine-catalyzed Markovnikov addition1• ;Tryptophan dioxygenase inhibitors pyridyl-ethenyl-indoles as potential anticancer immunomodulators2• ;Organic light emitting diodes (OLEDs)3• ;Anti inflammatory agents4• ;Potential cyclooxygenase-1 (COX-1)/cyclooxygenase-2 (COX-2) inhibitors5• ;Agents for cancer and malaria therapy6• ;Antifungal and antibacterial agents7• ;Fluorescent probes8Reactant in:• ;Difluorohydroxylation reactions†• ;Mannich-type reactions†

Uses

Phenylindole is a stabilizer in PVC-plastic products (α-phenylindole).

Uses

Reactant for preparation of:

  • Oxopyrrolidine analogs via iodine-catalyzed Markovnikov addition
  • Tryptophan dioxygenase inhibitors pyridyl-ethenyl-indoles as potential anticancer immunomodulators
  • Organic light emitting diodes (OLEDs)
  • Anti inflammatory agents
  • Potential cyclooxygenase-1 (COX-1)/cyclooxygenase-2 (COX-2) inhibitors
  • Agents for cancer and malaria therapy
  • Antifungal and antibacterial agents
  • Fluorescent probes

Reactant in:
  • Difluorohydroxylation reactions?
  • Mannich-type reactions?

Preparation

2-phenylindole is prepared by condensing phenylhydrazine and acetophenone, and then closing the ring in the presence of zinc chloride. or it can be prepared by heating bromoacetophenone with excess aniline, or heating N-(2-methylphenyl)benzamide and sodium ethoxide at 360-380℃ in isolation from air.

Definition

ChEBI: 2-phenyl-1H-indole is a phenylindole.

Synthesis Reference(s)

Tetrahedron Letters, 33, p. 1459, 1992 DOI: 10.1016/S0040-4039(00)91646-0
Journal of Heterocyclic Chemistry, 29, p. 1085, 1992 DOI: 10.1002/jhet.5570290509

2-Phenylindole Preparation Products And Raw materials

Raw materials

Ethanol Biphenyl Acetone Acetophenone 2-Bromoacetophenone Polyphosphoric acid Benzamide Acetic acid Phenylhydrazine

Preparation Products

3-[(2,4-dihydro-2,4-dimethyl-3H-1,2,4-triazol-3-ylidene)hydrazono]-1-methyl-2-phenyl-3H-indolium chloride
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2-Phenylindole Suppliers

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View Lastest Price from 2-Phenylindole manufacturers

Hebei Mujin Biotechnology Co.,Ltd
Product
2-Phenylindole 948-65-2
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-08-18
Hebei Zhuanglai Chemical Trading Co Ltd
Product
2-Phenylindole 948-65-2
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 ton
Release date
2024-12-23
WUHAN FORTUNA CHEMICAL CO., LTD
Product
2-Phenylindole 948-65-2
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-02-24

948-65-2, 2-PhenylindoleRelated Search:

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  • 1H-Indole,2-phenyl-
  • 2-phenyl-1h-indol
  • 2-phenyl-indol
  • a-Phenylindole
  • 2-Phenylindole ,99%
  • NSC 15776
  • 2-Phenylindole technical grade, 95%
  • PHENYLINDOL,ALPHA-
  • 2-PHENYLINDOLE
  • 2-PHENYL-1H-INDOLE
  • 2-PHENYLINDOLE, TECH., 95%
  • 2-Phenylindole,95%
  • alpha-Phenylindole
  • Indole, 2-phenyl-
  • -Phenylindole
  • Stabilizer I
  • stabilizeri
  • ALPHA-PHENYLINDOL
  • A-PHENYLINDOL
  • 2-Phenylindole ISO 9001：2015 REACH
  • 948-65-2
  • C6H5C8H6N
  • C14H10KN
  • Indoles
  • Simple Indoles
  • Heterocyclic Building Blocks
  • Building Blocks
  • Pyridines
  • Building Blocks
  • Heterocyclic Building Blocks
  • intermediates
  • Heterocycle-Indole series
  • Building Blocks
  • C13 to C27
  • Chemical Synthesis
  • Heterocyclic Building Blocks
  • Indoles
  • Simple Indoles
  • Heterocyclic Compounds
  • Indole