ASN-ARG-VAL-TYR-VAL-HIS-PRO-PHE

ChemicalBook > CAS DataBase List > ASN-ARG-VAL-TYR-VAL-HIS-PRO-PHE

ASN-ARG-VAL-TYR-VAL-HIS-PRO-PHE

Product Name: ASN-ARG-VAL-TYR-VAL-HIS-PRO-PHE
CAS No.: 53-73-6
Chemical Name: ASN-ARG-VAL-TYR-VAL-HIS-PRO-PHE
Synonyms: angiotensinamide;Angiotensin amide acetate;(ASN1,VAL5)-ANGIOTENSIN II;(Asn?,Val?)-Angiotensin II;ASN-ARG-VAL-TYR-VAL-HIS-PRO-PHE;hypertensin II, 1-amide-5-valyl;L-ASN-ARG-VAL-TYR-VAL-HIS-PRO-PHE;H-ASN-ARG-VAL-TYR-VAL-HIS-PRO-PHE-OH;[ASN1,VAL5]-ANGIOTENSIN II ACOH 4H2O;H2-ASN-ARG-VAL-TYR-VAL-HIS-PRO-PHE-OH
CBNumber: CB9735222
Molecular Formula: C49H70N14O11
Formula Weight: 1031.17
MOL File: 53-73-6.mol

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ASN-ARG-VAL-TYR-VAL-HIS-PRO-PHE Property

Density: 1.45±0.1 g/cm3(Predicted)
storage temp.: -15°C
pka: 3.56±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: FA109691
Product name: H-Asn-Arg-Val-Tyr-Val-His-Pro-Phe-OH
Packaging: 5mg
Price: $160
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA109691
Product name: H-Asn-Arg-Val-Tyr-Val-His-Pro-Phe-OH
Packaging: 10mg
Price: $250
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA109691
Product name: H-Asn-Arg-Val-Tyr-Val-His-Pro-Phe-OH
Packaging: 25mg
Price: $300
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA109691
Product name: H-Asn-Arg-Val-Tyr-Val-His-Pro-Phe-OH
Packaging: 50mg
Price: $450
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA109691
Product name: H-Asn-Arg-Val-Tyr-Val-His-Pro-Phe-OH
Packaging: 100mg
Price: $500
Updated: 2021/12/16

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ASN-ARG-VAL-TYR-VAL-HIS-PRO-PHE Chemical Properties,Usage,Production

Originator

Hypertensin,Ciba,W. Germany,1961

Definition

ChEBI: Angiotensinamide is an oligopeptide.

Manufacturing Process

48 mg (0.042 mmol) of L-asparaginyl-L-arginyl-L-valyl-L-tyrosyl-L-valyl-Lhistidyl- L-prolyl-L-phenylalanine methyl ester trihydrochloride are suspended in 0.5 ml of methanol, and treated gradually in the course of one hour with 0.3 ml of N-caustic soda solution (about 7 equivalents) so that the pH value of the solution is maintained between 10.5 and 11.5. After a further 30 minutes the solution is freed from methanol under vacuum at room temperature, adjusted with 1 N acetic acid to pH 7.4 and lyophilized. The residual mixture of free peptide and inorganic salts (79 mg) is fractionated by countercurrent distribution in the system butanol/0.1 N ammonium hydroxide. The pure octapeptide is obtained as a colorless powder which is soluble in water and methanol, more sparingly soluble in ethanol, and insoluble in acetone.

Therapeutic Function

Vasoconstrictor

General Description

Angiotensin amide (Hypertensin)is a synthetic polypeptide (1-L-aspariginyl-5-L-valine angiotensinoctapeptide) and has twice the pressor activity ofangiotensin II. It is pharmaceutically available as alyophilized powder for injection (0.5–2.5 mg diluted in500 mL of sodium chloride injection or 5% dextrose for injection)to be administered by continuous infusion. The pressoreffect of angiotensin is due to an increase in peripheralresistance; it constricts resistance vessels but has little or nostimulating action on the heart and little effect on the capacitancevessels. Angiotensin has been used as an adjunct invarious hypotensive states. It is mainly useful in controllingacute hypotension during administration of general anestheticsthat sensitize the heart to the effects of catecholamines.

ASN-ARG-VAL-TYR-VAL-HIS-PRO-PHE Preparation Products And Raw materials

Raw materials

Preparation Products

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53-73-6, ASN-ARG-VAL-TYR-VAL-HIS-PRO-PHERelated Search:

Angiotensin acetate Lenalidomide ANGIOTENSIN III, HUMAN ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE ACETATE SALT ANGIOTENSIN I/II (1-5) ABZ-GLY-4-NITRO-PHE-PRO-OH ANGIOTENSIN I/II (3-7) (DES-ASP1,ILE8)-ANGIOTENSIN II ASP-ARG-VAL-TYR ANGIOTENSIN I/II (1-6) H-MET-LYS-ARG-SER-ARG-GLY-PRO-SER-PRO-ARG-ARG-OH ANGIOTENSIN I/II (4-8) ANGIOTENSIN II, HUMAN Angiogenin (108-122) TFA BRADYKININ (1-6) H-ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-OH ANGIOTENSINOGEN (1-13) (HUMAN) (SAR1,ILE4,8)-ANGIOTENSIN II

ASN-ARG-VAL-TYR-VAL-HIS-PRO-PHE

ASN-ARG-VAL-TYR-VAL-HIS-PRO-PHE ACOH 4H2O

(ASN1,VAL5)-ANGIOTENSIN II

[ASN1,VAL5]-ANGIOTENSIN II ACOH 4H2O

H-ASN-ARG-VAL-TYR-VAL-HIS-PRO-PHE-OH

H2-ASN-ARG-VAL-TYR-VAL-HIS-PRO-PHE-OH

1-L-Asparagine-5-L-valineangiotensin II

L-Asn-L-Arg-L-Val-L-Tyr-L-Val-L-His-L-Pro-L-Phe-OH

2-[[1-[2-[[2-[[2-[[2-[[2-[(2,4-diamino-4-keto-butanoyl)amino]-5-guanidino-pentanoyl]amino]-3-methyl-butanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methyl-butanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-phenyl-propionic acid

L-ASN-ARG-VAL-TYR-VAL-HIS-PRO-PHE

angiotensinamide

hypertensin II, 1-amide-5-valyl

L-Phenylalanine, N-[1-[N-[N-[N-[N-(N(sup2)-L-asparaginyl-L-arginyl)-L-valyl]-L-tyrosyl]-L-valyl]-L-histidyl]-L-prolyl]-

2-[[1-[2-[[2-[[2-[[2-[[5-(diaminomethylideneamino)-2-[(2,4-diamino-4-oxobutanoyl)amino]pentanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylbutanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoic acid

2-[[1-[2-[[2-[[2-[[2-[[5-[bis(azanyl)methylideneamino]-2-[[2,4-bis(azanyl)-4-oxo-butanoyl]amino]pentanoyl]amino]-3-methyl-butanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methyl-butanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidin-2-yl]carbonylamino]-3-phenyl-propanoic acid

Angiotensin II, 1-L-asparagine-5-L-valine-

ASN-ARG-VAL-TYR-VAL-HIS-PRO-PHE USP/EP/BP

Angiotensin amide acetate

Angiotensin amide acetate(53-73-6 Free base)

(Asn?,Val?)-Angiotensin II

53-73-6