Chlortetracycline hydrochloride
- Product Name
- Chlortetracycline hydrochloride
- CAS No.
- 64-72-2
- Chemical Name
- Chlortetracycline hydrochloride
- Synonyms
- CHLORTETRACYCLINE HCL;CTC;AUREOMYCIN;CHLOROTETRACYCLINE HYDROCHLORIDE;CHLOROTETRACYCLINE HCL;AUREOMYCIN HYDROCHLORIDE;u-6780;nsc-13252;Auxeomycin;Isphamycin
- CBNumber
- CB9737862
- Molecular Formula
- C22H24Cl2N2O8
- Formula Weight
- 515.34
- MOL File
- 64-72-2.mol
Chlortetracycline hydrochloride Property
- Melting point:
- 210-215 °C (dec.)(lit.)
- alpha
- D23 -240°
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- 1 M NaOH: soluble50mg/mL
- form
- Powder
- color
- faint yellow to yellow
- pka
- 3.3(at 25℃)
- biological source
- Streptomyces aureofaciens
- Water Solubility
- Soluble in water
- Sensitive
- Light Sensitive
- Merck
- 13,2211
- BRN
- 3858364
- CAS DataBase Reference
- 64-72-2(CAS DataBase Reference)
- EPA Substance Registry System
- Chlortetracycline hydrochloride (64-72-2)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P202Do not handle until all safety precautions have been read and understood.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313IF exposed or concerned: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 26430
- Product name
- Chlortetracycline hydrochloride
- Purity
- suitable for fluorescence, BioReagent, from
- Packaging
- 5g
- Price
- $70.5
- Updated
- 2024/03/01
- Product number
- 46133
- Product name
- Chlortetracycline hydrochloride
- Purity
- VETRANAL?, analytical standard
- Packaging
- 250mg
- Price
- $74.1
- Updated
- 2024/03/01
- Product number
- 1129007
- Product name
- Chlortetracycline hydrochloride
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 200mg
- Price
- $447
- Updated
- 2024/03/01
- Product number
- J60095
- Product name
- Chlortetracycline hydrochloride
- Packaging
- 25g
- Price
- $128
- Updated
- 2024/03/01
- Product number
- J60095
- Product name
- Chlortetracycline hydrochloride
- Packaging
- 100g
- Price
- $378
- Updated
- 2024/03/01
Chlortetracycline hydrochloride Chemical Properties,Usage,Production
Description
Chlortetracycline was found in the culture broth of Streptomyces aureofaciens by Duggar et al. of Lederle Laboratories in 1948 and named aureomycin. It shows a wider range of antibiotic activity than the earlier antibiotics, penicillins, and streptomycins and as great as that of chloramphenicol. Its activity covers grampositive and gram-negative bacteria as well as Rickettsia and Chlamydiae. Chlortetracycline has been replaced by other tetracyclines in clinical use and is used now used as a feed additive to promote the growth of livestock.
Chemical Properties
Yellow Solid
Uses
antibacterial, antiamebic, Ca chelator, hepatotoxic; inhibits protein synthesis
Uses
Chlortetracycline is an antibiotic substance isolated from the substrate of Streptomyces aureofaciens. Chlortetracycline is an antimicrobial and antibacterial.
Uses
An antimicrobial and antibacterial. This compound contains an undetermined amount of epi-chlortetracycline
Uses
Chlortetracycline hydrochloride is a salt prepared from chlortetracycline taking advantage of the basic dimethylamino group which protonates and readily forms the salt in hydrochloric acid solutions. The hydrochloride is the preferred formulation for pharmaceutical applications. Like all tetracyclines, chlortetracycline shows broad spectrum antibacterial and antiprotozoan activity and acts by binding to the 30S and 50S ribosomal sub-units, blocking protein synthesis.
brand name
Aureomycin (Lederle).
General Description
Chlortetracycline (Aureomycin hydrochloride) was isolatedby Duggar in 1948 from S. aureofaciens. This compound,which was produced in an extensive search for new antibiotics,was the first of the group of highly successful tetracyclines.It soon became established as a valuable antibioticwith broad-spectrum activities.
It is used in medicine chiefly as the acid salt of the compoundwhose systematic chemical designation is 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide.The hydrochloride salt is a crystallinepowder with a bright yellow color, which suggested itsbrand name, Aureomycin. It is stable in air but slightly photosensitiveand should be protected from light. It is odorlessand bitter. One gram of the hydrochloride salt will dissolvein about 75 mL of water, producing a pH of about 3. It isonly slightly soluble in alcohol and practically insoluble inother organic solvents.
Oral and parenteral forms of chlortetracycline are nolonger used because of the poor bioavailability and inferiorpharmacokinetic properties of the drug. It is still marketed inointment forms for topical and ophthalmic use.
Purification Methods
Purify the salt by dissolving 1g rapidly in 20mL of hot water, cooling rapidly to 40o, treating with 0.1mL of 2M HCl, and chilling in an ice-bath. The process is repeated twice. It is also recrystallised from Me2NCHO/Me2CO. [Stephens et al. J Am Chem Soc 76 3568 1954, UV: McCormick et al. J Am Chem Soc 79 2849 1975, Beilstein 14 IV 2631.]
Chlortetracycline hydrochloride Preparation Products And Raw materials
Raw materials
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View Lastest Price from Chlortetracycline hydrochloride manufacturers
- Product
- Chlortetracycline hydrochloride 64-72-2
- Price
- US $0.00/kg
- Min. Order
- 25kg
- Purity
- ≥97.0%
- Supply Ability
- 1tons
- Release date
- 2024-04-28
- Product
- Chlortetracycline hydrochloride 64-72-2
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-07-03
- Product
- Chlortetracycline Hcl 64-72-2
- Price
- US $150.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 500kg
- Release date
- 2024-12-04