?Synthesis
ChemicalBook > CAS DataBase List > 2-(2-Aminoethyl)isothiourea dihydrobromide

2-(2-Aminoethyl)isothiourea dihydrobromide

?Synthesis
Product Name
2-(2-Aminoethyl)isothiourea dihydrobromide
CAS No.
56-10-0
Chemical Name
2-(2-Aminoethyl)isothiourea dihydrobromide
Synonyms
AET;ixecur;usafxr-31;surrectan;ANTIRADON;NSC 22877;AET, DiHBr;AET-NSC-22877;AET, DIHYDROBROMIDE;IFLAB-BB F0861-0023
CBNumber
CB9753183
Molecular Formula
C3H11Br2N3S
Formula Weight
281.01
MOL File
56-10-0.mol
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2-(2-Aminoethyl)isothiourea dihydrobromide Property

Melting point:
190-196 °C(lit.)
Density 
1.94 g/cm3
storage temp. 
Store below +30°C.
solubility 
50g/l
form 
powder to crystal
color 
White to Almost white
Water Solubility 
almost transparency
Merck 
14,178
BRN 
3911163
CAS DataBase Reference
56-10-0(CAS DataBase Reference)
EPA Substance Registry System
Carbamimidothioic acid, 2-aminoethyl ester, dihydrobromide (56-10-0)
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
26-36/37-22
WGK Germany 
3
RTECS 
UM0175000
F 
10-21
TSCA 
Yes
HS Code 
2930 90 98
Toxicity
LD50 in mice (mg/kg): 100 i.v., 280 s.c., 480 i.p., 1600 orally (Pospisil)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A5879
Product name
2-(2-Aminoethyl)isothiourea dihydrobromide
Packaging
25g
Price
$98.5
Updated
2024/03/01
Sigma-Aldrich
Product number
8.20064
Product name
S-(2-Aminoethyl)thiouronium bromide hydrobromide
Purity
for synthesis
Packaging
10g
Price
$68.2
Updated
2024/03/01
TCI Chemical
Product number
A1078
Product name
S-(2-Aminoethyl)isothiouronium Bromide Hydrobromide
Purity
>98.0%(T)
Packaging
25g
Price
$55
Updated
2024/03/01
Alfa Aesar
Product number
L14232
Product name
S-(2-Aminoethyl)isothiourea dihydrobromide, 98%
Packaging
5g
Price
$21.65
Updated
2024/03/01
Alfa Aesar
Product number
L14232
Product name
S-(2-Aminoethyl)isothiourea dihydrobromide, 98%
Packaging
25g
Price
$56.65
Updated
2024/03/01
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2-(2-Aminoethyl)isothiourea dihydrobromide Chemical Properties,Usage,Production

?Synthesis

Ethylamine thiourea is synthesized by using cycloethylamine, hydrobromic acid and thiourea as raw materials: firstly, thiourea is mixed with hydrogen bromide acid, and cycloethylamine is added dropwise at a temperature below 150 °C. After the reaction is completed, add activated carbon to filter, and then reduce Dehydration under pressure, crystals are precipitated when the temperature is below 50°C, filtered, and washed twice with absolute ethanol.

Description

S-(2-aminoethyl) Isothiourea is a non-selective inhibitor of all NOS isoforms. For human nNOS, eNOS, and iNOS, the Ki values are 1.8, 2.1, and 0.59 μM, respectively.

Chemical Properties

Crystals, hygroscopic.

Uses

2-(2-Aminoethyl)isothiourea dihydrobromide inhibits nitric oxide synthase (NOS).

Uses

Has radioprotective activity against x-rays.

Uses

NOS inhibitor

Purification Methods

Crystallise the salt from absolute EtOH/ethyl acetate or MeOH. Store dry as it is hygroscopic in a humid atmosphere. It is a radioprotective agent. When refluxed in EtOH for 16hours or H2O for 30minutes, it decomposes to 2-amino-4(5H)-thiazoline hydrobromide which on recrystallisation from isoPrOH/EtOAc has m 175-176o [Doherty et al. J Am Chem Soc 79 5667 1957].

References

[1]. garvey ep, oplinger ja, tanoury gj, et al. potent and selective inhibition of human nitric oxide synthases. inhibition by non-amino acid isothioureas. j biol chem. 1994 oct 28;269(43):26669-76.

2-(2-Aminoethyl)isothiourea dihydrobromide Preparation Products And Raw materials

Raw materials

Monoethanolamine Hydrogen bromide 2-Bromoethylamine hydrobromide Ethyleneimine

Preparation Products

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2-(2-Aminoethyl)isothiourea dihydrobromide Suppliers

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View Lastest Price from 2-(2-Aminoethyl)isothiourea dihydrobromide manufacturers

Dideu Industries Group Limited
Product
2-(2-Aminoethyl)isothiourea dihydrobromide 56-10-0
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-07-27
Career Henan Chemical Co
Product
2-(2-Aminoethyl)isothiourea dihydrobromide 56-10-0
Price
US $100.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
Customized
Release date
2018-07-26

56-10-0, 2-(2-Aminoethyl)isothiourea dihydrobromideRelated Search:

N-Aminothiourea 1-PHENYL-2-THIOUREA 2-(2-Aminoethylamino)ethanol Dextromethorphan hydrobromide monohydrate Thiourea PHENAZINE ETHOSULFATE Allyl bromide Rocuronium bromide Galantamine Hydrobromide N,N'-Diethylthiourea N-Aminoethylpiperazine Ethylamine Hydrogen bromide Pyridine hydrobromide Sodium bromate Ethidium bromide Ethylamine hydrochloride Methyl bromide

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