(3R)-(+)-1-BENZYL-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE

Product Name: (3R)-(+)-1-BENZYL-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE
CAS No.: 131878-23-4
Chemical Name: (3R)-(+)-1-BENZYL-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE
Synonyms: (R)-1-Benzyl-3-NBoc-aMinopyrrolidin;(R)-1-BENZYL-3-N-BOC-AMINO-PYRROLIDINE;TERT-BUTYL(R)-1-BENZYLPYRROLIDIN-3-YLCARBAMATE;(R)-Tert-butyl 1-benzylpyrrolidin-3-ylcarbamate;(R)-(+)-1-Benzyl-3-(Boc-amino)pyrrolidine;tert-butyl N-[(3R)-1-benzylpyrrolidin-3-yl]carbamate;(R)-1-BENZYL-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE;(R)-1-BENZLY-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE;(3R)-(+)-1-BENZYL-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE;(R)-(1-BENZYL-PYRROLIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER
CBNumber: CB9763580
Molecular Formula: C16H24N2O2
Formula Weight: 276.37
MOL File: 131878-23-4.mol

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(3R)-(+)-1-BENZYL-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE Property

Melting point:: 77-81 °C(lit.)
Boiling point:: 385.1±31.0 °C(Predicted)
Density: 1.08
refractive index: 18.5 ° (C=2, EtOH)
storage temp.: 2-8°C
solubility: almost transparency in Methanol
form: powder to crystal
pka: 12.31±0.20(Predicted)
color: White to Almost white
optical activity: [α]20/D +6°, c = 1% in chloroform
CAS DataBase Reference: 131878-23-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 649961
Product name: (R)-(+)-1-Benzyl-3-(Boc-amino)pyrrolidine
Purity: 97%
Packaging: 1g
Price: $68.7
Updated: 2023/01/07

TCI Chemical

Product number: B1932
Product name: (3R)-(+)-1-Benzyl-3-(tert-butoxycarbonylamino)pyrrolidine
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $86
Updated: 2025/07/31

TRC

Product number: B750238
Product name: (R)-tert-Butyl(1-Benzylpyrrolidin-3-yl)carbamate
Packaging: 50mg
Price: $45
Updated: 2021/12/16

Chem-Impex

Product number: 41587
Product name: (R)-(+)-1-Benzyl-3-(Boc-amino)pyrrolidine,≥98%(GC)
Purity: ≥98%(GC)
Packaging: 1G
Price: $67.56
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB60242
Product name: (3R)-(+)-1-Benzyl-3-(tert-butoxycarbonylamino)pyrrolidine
Packaging: 2g
Price: $69
Updated: 2021/12/16

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(3R)-(+)-1-BENZYL-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE Chemical Properties,Usage,Production

Synthesis

24424-99-5

114715-39-8

131878-23-4

The general procedure for the synthesis of (R)-1-benzyl-3-(tert-butoxycarbonylamino)pyrrolidine from di-tert-butyl dicarbonate and (R)-1-benzyl-3-amino pyrrolidine was as follows: first, sodium bicarbonate (5.92 g, 70.5 mmol) was dissolved in 118 mL of deionized water, and then this solution was added to a 118 mL acetonitrile solution of (R)-(+)-benzylamino pyrrolidine 1a (5.00 g, 28.4 mmol) in 118 mL of acetonitrile solution. The mixture was stirred at room temperature for 10 minutes. Subsequently, di-tert-butyl dicarbonate (6.22 g, 28.5 mmol) was added and stirring was continued overnight at room temperature. After completion of the reaction, the reaction solution was concentrated under reduced pressure and the residue was extracted three times with dichloromethane. The organic layers were combined, dried over anhydrous sodium sulfate, filtered and concentrated. The residue was purified by fast column chromatography (eluent ratio methanol: dichloromethane = 2:98). Finally, the solvent was removed in vacuum to afford 4.24 g of tert-butyl (R)-(1-benzylpyrrolidin-3-yl)carbamate in 65.2% yield. The product was characterized by 1H NMR (400 MHz, CDCl3): δ 7.36-7.26 (m, 5H), 4.86 (bs, 1H), 4.18 (bs, 1H), 3.61 (s, 2H), 2.79 (bs, 1H), 2.65-2.61 (m, 1H), 2.54 (d, J=8.0 Hz, 1H), 2.34- 2.25 (m, 2H), 1.61-1.51 (m, 1H), 1.46 (s, 9H). The specific optical rotation [α]D was +2.5° (c 0.620, CHCl3).

References

[1] Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 8, p. 1495 - 1510
[2] Journal of Medicinal Chemistry, 2001, vol. 44, # 11, p. 1815 - 1826
[3] Journal of Medicinal Chemistry, 2002, vol. 45, # 3, p. 721 - 739

(3R)-(+)-1-BENZYL-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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(3R)-(+)-1-BENZYL-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE Suppliers

Americas 1 China 73 Europe 1 Germany 3 India 2 Japan 1 Switzerland 1 United Kingdom 3 United States 16 Global 101

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View Lastest Price from (3R)-(+)-1-BENZYL-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE manufacturers

Career Henan Chemical Co

Product: (3R)-(+)-1-BENZYL-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE 131878-23-4
Price: US $8.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10tons
Release date: 2018-12-25

131878-23-4, (3R)-(+)-1-BENZYL-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINERelated Search:

1-BENZYL-3-TERT-BUTOXYCARBONYLAMINO-PYRROLIDINE-3-CARBOXYLIC ACID (S)-1-BENZYL-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE (3R)-(+)-3-(METHYLAMINO)PYRROLIDINE 1-Benzyl-3-aminopyrrolidine 2-((R)-3-(tert-butoxycarbonylamino)pyrrolidin-1-yl)-2-m-tolylacetic acid (3R)-(+)-1-BENZYL-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE TRANS-1-BENZYL-4-TERT-BUTOXYCARBONYLAMINO-PYRROLIDINE-3-CARBOXYLIC ACID,TRANS-RACEMIC-1-BENZYL-4-TERT-BUTOXYCARBONYLAMINO-PYRROLIDINE-3-CARBOXYLIC ACID (S)-3-BOC-AMINO-BUTYLAMINE (S)-3-(Boc-amino)pyrrolidine (3-BENZYLAMINO-1-METHYL-PROPYL)-CARBAMIC ACID TERT-BUTYL ESTER Carbamic acid, [3-(dimethylamino)propyl]-, 1,1-dimethylethyl ester (9CI) 1-BENZYL-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE (3R)-(-)-1-BENZYL-3-(METHYLAMINO)PYRROLIDINE (S)-(+)-1-Benzyl-3-aminopyrrolidine 3-N-Boc-aminopyrrolidine Carbamic acid, [3-(propylamino)propyl]-, 1,1-dimethylethyl ester (9CI)

(R)-1-BENZYL-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE

(R)-(1-BENZYL-PYRROLIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER

(3R)-(+)-1-Benzyl-3-(tert-butoxycarbonylamino)pyrrolidine

tert-butyl N-[(3R)-1-benzylpyrrolidin-3-yl]carbamate

TERT-BUTYL(R)-1-BENZYLPYRROLIDIN-3-YLCARBAMATE

CARBAMIC ACID,[(3R)-1-(PHENYLMETHYL)-3-PYRROLIDINYL]-,1,1-DIMETHYLETHYL ESTER

(3R)-(+)-1-BENZYL-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE

(3R)-(+)-1-BENZYL-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE 98+%

(R)-1-BENZLY-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE

(R)-1-BENZYL-3-N-BOC-AMINO-PYRROLIDINE

(R)-Tert-butyl 1-benzylpyrrolidin-3-ylcarbamate

(R)-1-Benzyl-3-NBoc-aMinopyrrolidin

[(3R)-1-(Phenylmethyl)-3-pyrrolidinyl]-carbamic acid 1,1-dimethylethyl ester

(3R)-(+)-1-Benzyl-3-(tert-butoxycarbonylamino)pyrrolidine &gt

Carbamic acid, N-[(3R)-1-(phenylmethyl)-3-pyrrolidinyl]-, 1,1-dimethylethyl ester

(3R)-(+)-1-Benzyl-3-(tert-butoxycarbonylamino)pyrrolidine/(R)-1-Benzyl-3-(tert-butoxycarbonylamino)pyrrolidine

(R)-(+)-1-Benzyl-3-(Boc-amino)pyrrolidine

131878-23-4

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