3-ALLYLSALICYLALDEHYDE
- Product Name
- 3-ALLYLSALICYLALDEHYDE
- CAS No.
- 24019-66-7
- Chemical Name
- 3-ALLYLSALICYLALDEHYDE
- Synonyms
- AKOS BBS-00003205;TIMTEC-BB SBB010096;3-Allylsalicyladehyde;3-ALLYLSALICYLALDEHYDE;3-ALLYL SALCYLALDEHYDE;ASINEX-REAG BAS 02801117;Rivaroxaban Impurity 191;Salicylaldehyde, 3-allyl-;3-Allylsalicylaldehyde 97%;3-Allylsalicylaldehyde, 96.5%
- CBNumber
- CB9767179
- Molecular Formula
- C10H10O2
- Formula Weight
- 162.19
- MOL File
- 24019-66-7.mol
3-ALLYLSALICYLALDEHYDE Property
- Melting point:
- 45 °C
- Boiling point:
- 248.88°C (rough estimate)
- Density
- 1.099 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.5645
- Flash point:
- 224 °F
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Soluble in chloroform.
- pka
- 8.50±0.10(Predicted)
- form
- Oil
- color
- Light Yellow to Yellow
- Sensitive
- Air Sensitive
- InChI
- InChI=1S/C10H10O2/c1-2-4-8-5-3-6-9(7-11)10(8)12/h2-3,5-7,12H,1,4H2
- InChIKey
- INLWEXRRMUMHKB-UHFFFAOYSA-N
- SMILES
- C(=O)C1=CC=CC(CC=C)=C1O
- CAS DataBase Reference
- 24019-66-7(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 636339
- Product name
- 3-Allylsalicylaldehyde
- Purity
- 97%
- Packaging
- 5g
- Price
- $161.5
- Updated
- 2025/07/31
- Product number
- 636339
- Product name
- 3-Allylsalicylaldehyde
- Purity
- 97%
- Packaging
- 1g
- Price
- $93
- Updated
- 2023/06/20
- Product number
- A575000
- Product name
- 3-AllylSalicylaldehyde
- Packaging
- 100g
- Price
- $970
- Updated
- 2021/12/16
- Product number
- A575000
- Product name
- 3-AllylSalicylaldehyde
- Packaging
- 1g
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 018548
- Product name
- 3-Allyl-2-hydroxy-benzaldehyde
- Packaging
- 1g
- Price
- $68
- Updated
- 2021/12/16
3-ALLYLSALICYLALDEHYDE Chemical Properties,Usage,Production
Chemical Properties
Light Yellow Liquid
Uses
3-Allyl Salicylaldehyde is a synthetic intermediate for the sythesis of 3-aminoflavones. Flavonoids have been studied for their antiproliferative activity and in vitro cytotoxicity. Used in the prepar ation of oxazole derivatives. Used in the preparation of imidazole scaffold-based 2-substituted benzofurans for application against human tumor cell lines. Also a reagent in the synthesis of antioxida nt and antimicrobial novel chalcones.
Uses
3-Allylsalicylaldehyde is a synthetic intermediate for the synthesis of 3-aminoflavones. Flavonoids have been studied for their antiproliferative activity and in vitro cytotoxicity. It is used in the preparation of oxazole derivatives and also imidazole scaffold-based 2-substituted benzofurans for application against human tumor cell lines. It is a reagent in the synthesis of antioxidant and antimicrobial novel chalcones.
Synthesis
50-00-0
1745-81-9
24019-66-7
The general procedure for the synthesis of 3-allyl-2-hydroxybenzaldehyde from formaldehyde and 2-allylphenol was as follows: 13.5 g (0.1 mol) of 2-allylphenol and 100 mL of acetonitrile were added to a three-necked flask, and 6.5 g of paraformaldehyde, 22 g (0.39 mol) of anhydrous magnesium chloride, and 0.02 mol of triethylamine were added sequentially under stirring conditions. The reaction mixture was refluxed for 4 h. The reaction solution was poured into ice water and the pH was adjusted with aqueous hydrochloric acid to 5. It was extracted twice with ethyl acetate, the organic phases were combined and dried over anhydrous sodium sulfate. After concentration under reduced pressure, 11 g of solid product was obtained in 68% yield. Mass spectrometry analysis showed a molecular ion peak of 163 (M + 1).
References
[1] Patent: US2012/142921, 2012, A1. Location in patent: Page/Page column 13
[2] Patent: EP2468730, 2012, A1. Location in patent: Page/Page column 14
[3] Journal of Medicinal Chemistry, 2000, vol. 43, # 8, p. 1525 - 1532
[4] Organic Letters, 2012, vol. 14, # 12, p. 3226 - 3229
3-ALLYLSALICYLALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-ALLYLSALICYLALDEHYDE manufacturers
- Product
- 3-ALLYLSALICYLALDEHYDE 24019-66-7
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2019-12-25