Ethoxymethylenemalononitrile

Product Name: Ethoxymethylenemalononitrile
CAS No.: 123-06-8
Chemical Name: Ethoxymethylenemalononitrile
Synonyms: 2-(ETHOXYMETHYLENE)MALONONITRILE;2-(Ethoxymethylene)propanedinitrile;ononitriL;ETHOXYMETHYLENEMALONITRILE;(Ethoxymethylene)propanedinitrile;usafkf-10;NSC 27792;USAF KF-10;usafa-9230;USAF a-9230
CBNumber: CB9767407
Molecular Formula: C6H6N2O
Formula Weight: 122.12
MOL File: 123-06-8.mol

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Ethoxymethylenemalononitrile Property

Melting point:: 64-66 °C(lit.)
Boiling point:: 160 °C12 mm Hg(lit.)
Density: 1.2236 (rough estimate)
refractive index: 1.4738 (estimate)
Flash point:: 155 °C
storage temp.: Inert atmosphere,Room Temperature
solubility: DMF, DMSO, Ethanol, Methanol
form: Liquid
color: Clear colorless to yellow
Water Solubility: insoluble
BRN: 1634241
InChIKey: OEICGMPRFOJHKO-UHFFFAOYSA-N
CAS DataBase Reference: 123-06-8(CAS DataBase Reference)
NIST Chemistry Reference: Propanedinitrile, (ethoxymethylene)-(123-06-8)
EPA Substance Registry System: Propanedinitrile, (ethoxymethylene)- (123-06-8)

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Safety

Hazard Codes: Xn,T,Xi
Risk Statements: 22-42/43-23/24/25-43-20/21/22-R42/43-R23/24/25-R22
Safety Statements: 22-36/37-45-36/37/39-26-36-24/25-S45-S36/37/39-S26-S22
RIDADR: 3439
WGK Germany: 3
RTECS: OO3850000
F: 21
TSCA: Yes
HazardClass: 6.1
PackingGroup: III
HS Code: 29269090
Toxicity: mouse,LD50,intraperitoneal,50mg/kg (50mg/kg),National Technical Information Service. Vol. AD277-689,

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: E6200
Product name: (Ethoxymethylene)malononitrile
Purity: 98%
Packaging: 100g
Price: $32.84
Updated: 2024/03/01

Sigma-Aldrich

Product number: E6200
Product name: (Ethoxymethylene)malononitrile
Purity: 98%
Packaging: 25g
Price: $37.8
Updated: 2024/03/01

TCI Chemical

Product number: E0649
Product name: (Ethoxymethylene)malononitrile
Purity: >98.0%(GC)
Packaging: 25g
Price: $74
Updated: 2024/03/01

Alfa Aesar

Product number: A14412
Product name: Ethoxymethylenemalononitrile, 97+%
Packaging: 25g
Price: $45.65
Updated: 2024/03/01

Alfa Aesar

Product number: A14412
Product name: Ethoxymethylenemalononitrile, 97+%
Packaging: 100g
Price: $99.65
Updated: 2024/03/01

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Ethoxymethylenemalononitrile Chemical Properties,Usage,Production

Description

Ethoxymethylenemalononitrile (EMMN) is an orange solid and the melting point of EMMN is 64–66 °C[1].It is an inexpensive reagent. As a functionalized malono-nitrile, it is widely used to synthesize pyrazoles, pyrimidines and a variety of fused heterocyclic systems.

Chemical Properties

Off White to Pale Yellow

Uses

Chemical intermediate.

Uses

Ethoxymethylene Malononitrile (cas# 123-06-8) is a compound useful in organic synthesis.

Preparation

Triethyl orthoformate (67.3 mg, 0.454 mol) and malononitrile (20.0 mg,0.302 mol) were andded to acetic anhydride (77.2 gm, 0.75 moles) and the mixture was refluxed for 4-5 h at 110-140°C. The reaction was monitored by GC. After the reaction is complete, it is cooled to room temperature. Concentrated the mixture at 70°C at reduced pressure to yield crude solid product and the pure product (Ethoxymethylenemalononitrile) was obtained through purified either by vacuum distillation.

Synthesis Reference(s)

Tetrahedron Letters, 10, p. 3279, 1969 DOI: 10.1017/S0009838800024678

References

[1] Faria J, et al. Ethoxymethylenemalononitrile. Synlett , 2013; 24: 0264–0265.
[2] Maurício , et al. Synthesis and antileishmanial evaluation of 1-aryl-4-(4,5-dihydro-1H-imidazol-2-yl)-1H-pyrazole derivatives. Bioorganic & Medicinal Chemistry Letters, 2011; 21: 7451-7454.

Ethoxymethylenemalononitrile Preparation Products And Raw materials

Raw materials

Preparation Products

[4-AMINO-2-(TRIFLUOROMETHYL)PYRIMIDIN-5-YL]METHANOL 4-AMINO-2-METHYLPYRIMIDINE-5-CARBONITRILE 4-AMINO-2-MERCAPTOPYRIMIDINE-5-CARBONITRILE 4-AMINO-2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBALDEHYDE 4-AMINO-2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBONITRILE 4-AMINO-2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLIC ACID 4-AMINO-5-AMINOMETHYL-2-METHYLPYRIMIDINE 4-AMINO-2-CHLOROPYRIMIDINE-5-CARBONITRILE 4-AMINO-2-METHYL-PYRIMIDINE-5-CARBOXYLIC ACID 5-(AMINOMETHYL)-2-(TRIFLUOROMETHYL)PYRIMIDIN-4-AMINE

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Ethoxymethylenemalononitrile Suppliers

Americas 1 Australia 1 Belgium 3 Canada 2 China 251 Czech Republic 1 Europe 6 Germany 6 India 27 Japan 4 Russia 1 Slovakia 1 South Korea 1 Spain 1 Switzerland 3 The Netherlands 2 United Kingdom 21 United States 61 Global 393

P&S Chemicals

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Country: The Netherlands
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PMC Chemicals

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ProdList: 265
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View Lastest Price from Ethoxymethylenemalononitrile manufacturers

Xinxiang Hongqi District Houyuan Trading Co.,Ltd

Product: Ethoxymethylenemalononitrile 123-06-8
Price: US $0.00/Kg
Min. Order: 1Kg
Purity: 99.0% up
Supply Ability: 50 tons per month
Release date: 2023-04-26

Honest Joy Holdings Limited

Product: (Ethoxymethylene)malononitrile 123-06-8
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 100 tons
Release date: 2022-02-20

Zhuozhou Wenxi import and Export Co., Ltd

Product: Ethoxymethylenemalononitrile 123-06-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

123-06-8, EthoxymethylenemalononitrileRelated Search:

Diethyl methylmalonate Ethoxyquin 2-Methylpropanedioic acid CITRATE SYNTHASE 2,2-DIMETHYL-1,3-PROPANEDIAMINE Tosylmethyl isocyanide Malononitrile Ethyl 3-ethoxypropionate Diethyl ethoxymethylenemalonate ETHOXYLATED COCOAMINE (LATEX STABILIZER) Ethylamine hydrochloride 2-Methoxyethyl acetoacetate Poly(oxy-1,2-ethanediyl), .alpha.-hydro-.omega.-(1-oxo-2-propenyl)oxy-, ether with 2,2-bis(hydroxymethyl)-1,3-propanediol (4:1) Ethoxyamine hydrochloride CHLOROMETHYLDIMETHYLETHOXYSILANE 1,1,2-TRIETHOXYETHANE Ethoxyacetic acid Acetoxyacetyl chloride

ETHOXYMETHYLENEMALONITRILE

ETHOXYMETHYLENEMALONONITRILE

ETHOXYMETHYLENMALONONITRILE

(beta-Ethoxymethylene)malononitrile

(b-Ethoxymethylene)malononitrile

(ethoxymethylene)-malononitril

(ethoxymethylene)-propanedinitril

(Ethoxymethylene)propanedinitrile

1,1-Dicyano-2-ethoxyethene

1-Ethoxy-2,2-dicyanoethene

2-Cyano-3-ethoxyacrylonitrile

2-Ethoxy-1,1-ethenedicarbonitrile

a-Cyano-b-ethoxyacrylonitrile

alpha-Cyano-beta-ethoxyacrylonitrile

Ethoxymethylene-malonic acid dinitrile

Malononitrile, (ethoxymethylene)-

USAF a-9230

USAF KF-10

usafa-9230

LABOTEST-BB LT01148236

2-(ETHOXYMETHYLIDENE)MALONONITRILE

2-(ETHOXYMETHYLENE)MALONONITRILE

PROPANEDINITRILE, (ETHOXYMETHYLENE)-

usafkf-10

ETHOXY METHYLENE MALONOITRILE-

Ethoxy methlenemalononitrile

1-Ethoxy-2,2-dicyanoethylene

Ethoxymethylenemalononitrile ,98%

2-(Ethoxymethylene)propanedinitrile

Ethoxymethylenemalononiyrile

ononitriL

NSC 27792

α-Cyano-β-ethoxyacrylonitrile

Propanedinitrile, 2-(ethoxyMethylene)-

Ethoxy heartland of Methyl Malononitrile

(Ethoxymethylene)malononitrile&gt

Ethoxy malononitrile

Ethoxymethylenmalononitril

2-(Ethoxymethylene)propanedinitrile (or) 2-(ethoxymethylene)malononitrile

ethoxymethylmalonitrile

2-(ethoxymethylene)malonitrile

123-06-8

C6H6N20

C2H5OCHCCN2

Organic Building Blocks

Nitrogen Compounds

Cyanides/Nitriles

Building Blocks

C6 to C7

Aliphatic Compound

Miscellaneous

API intermediates

Various Intermediates

Intermediates

C6 to C7

Cyanides/Nitriles

Nitrogen Compounds

Pharmaceutical Intermediates