2-Fluorobenzamide
- Product Name
- 2-Fluorobenzamide
- CAS No.
- 445-28-3
- Chemical Name
- 2-Fluorobenzamide
- Synonyms
- Benzamide, 2-fL;2-FLUOROBENZAMIDE;o-fluoro-benzamid;2-fluoro-benzamid;O-FLUOROBENZAMIDE;Benzamide, 2-fluoro-;2-Fluorobenzamide>ortho-Fluorobenzamide;2-Fluorobenzamide,98%;LABOTEST-BB LT00848244
- CBNumber
- CB9770193
- Molecular Formula
- C7H6FNO
- Formula Weight
- 139.13
- MOL File
- 445-28-3.mol
2-Fluorobenzamide Property
- Melting point:
- 117-119 °C (lit.)
- Boiling point:
- 238.4±23.0 °C(Predicted)
- Density
- 1.2099 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly), DMSO (Slightly)
- form
- powder to crystal
- pka
- 15.27±0.50(Predicted)
- color
- White to Almost white
- BRN
- 2325863
- InChI
- InChI=1S/C7H6FNO/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,(H2,9,10)
- InChIKey
- KGGHWIKBOIQEAJ-UHFFFAOYSA-N
- SMILES
- C(N)(=O)C1=CC=CC=C1F
- CAS DataBase Reference
- 445-28-3(CAS DataBase Reference)
- NIST Chemistry Reference
- Benzamide, 2-fluoro-(445-28-3)
- EPA Substance Registry System
- Benzamide, 2-fluoro- (445-28-3)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 37/39-26-24/25
- WGK Germany
- 3
- RTECS
- CV4953333
- HazardClass
- IRRITANT
- HS Code
- 29242990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- F0278
- Product name
- 2-Fluorobenzamide
- Purity
- >98.0%(T)
- Packaging
- 10g
- Price
- $147
- Updated
- 2025/07/31
- Product number
- F598015
- Product name
- 2-Fluorobenzamide
- Packaging
- 500mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- F598015
- Product name
- 2-Fluorobenzamide
- Packaging
- 2.5g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- R426
- Product name
- 2-Fluorobenzamide
- Packaging
- 5g
- Price
- $14
- Updated
- 2021/12/16
- Product number
- JK559070
- Product name
- 2-Fluorobenzamide
- Purity
- 98%
- Packaging
- 5g
- Price
- $25
- Updated
- 2021/12/16
2-Fluorobenzamide Chemical Properties,Usage,Production
Chemical Properties
white crystalline powder
Uses
2-Fluorobenzamide can be useful in microwave assisted preparation of oxazole-dehydrozingerone based hybrid molecules as anti-tubercular agents and their docking for Mtb DNA gyrase.
General Description
2-Fluorobenzamide inhibits the activity of poly(ADP-ribose) synthetase in vitro. It undergoes coupling with anilines in the presence of lithium amides to yield N-arylanthranilamides.
Synthesis
24652-66-2
445-28-3
The general procedure for the synthesis of o-fluorobenzamide from (E)-2-fluorobenzaldehyde oxime was as follows: (E)-2-fluorobenzaldehyde oxime (69.6 mg, 0.5 mmol) and [Cp*Ir(H2O)3][OTf]2 (5.1 mg, 0.0075 mmol) were added sequentially to a 25 mL Schlenk reaction flask. The reaction mixture was stirred at 110 °C for 12 hours. After completion of the reaction, the mixture was cooled to room temperature and the solvent was removed by rotary evaporation. The crude product was purified by column chromatography to give o-fluorobenzamide in 83% yield. The structure of the product was confirmed by nuclear magnetic resonance hydrogen (1H NMR) and carbon (13C NMR) spectra: 1H NMR (400 MHz, DMSO-d6) δ 7.54-7.50 (m, 1H, ArH), 7.29-7.25 (m, 3H, ArH); 13C NMR (100 MHz, DMSO-d6) δ 162.3 (d, JCF = 247.7 Hz), 132.4 (d, JCF = 8.8 Hz), 130.1 (d, JCF = 6.6 Hz), 124.3 (d, JCF = 2.6 Hz), 123.8 (d, JCF = 14.0 Hz), 116.0 (d, JCF = 22.5 Hz).
References
[1] RSC Advances, 2016, vol. 6, # 43, p. 37093 - 37098
[2] Organometallics, 2012, vol. 31, # 17, p. 6482 - 6490
[3] Catalysis Science and Technology, 2014, vol. 4, # 4, p. 988 - 996
[4] Patent: CN104418682, 2016, B. Location in patent: Paragraph 0047-0050
2-Fluorobenzamide Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Fluorobenzamide manufacturers
- Product
- 2-Fluorobenzamide 445-28-3
- Price
- US $1.00-28.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20000KG
- Release date
- 2024-07-29
- Product
- 2-Fluorobenzamide 445-28-3
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 97.1%
- Supply Ability
- 100 tons
- Release date
- 2022-02-18
- Product
- 2-Fluorobenzamide 445-28-3
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 95%-99%
- Supply Ability
- 100kg
- Release date
- 2018-12-20