Siltuximab

Product Name: Siltuximab
CAS No.: 541502-14-1
Chemical Name: Siltuximab
Synonyms: CNTO-328;Siltuximab;Siltuximab (anti-IL-6);Research Grade Siltuximab;Research Grade Siltuximab(DHC15801)
CBNumber: CB98080799
Formula Weight: 0
MOL File: Mol file

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Siltuximab Property

storage temp.: Store at -20°C
form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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Siltuximab Chemical Properties,Usage,Production

Uses

Siltuximab it is used for cancer treatment using anti-ICOS antibody if patient has low peripheral T cell receptor clonality.

Clinical Use

Chimeric (human-murine) immunoglobulin G1κ (IgG1κ) monoclonal antibody:
Treatment of multicentric Castleman’s disease (MCD)

in vivo

Siltuximab (intraperitoneal injection; 10 mg/kg; 3 times per week) inhibits the growth of lung cancer cells in xenograft mouse model^[1].
Siltuximab (intraperitoneal injection; 20 mg/kg; twice per week; 6 w) inhibits the growth of MCF-7 tumor in xenograft model^[4].

Animal Model:	Female CD-1 nu/nu mice injected with H1650 (adenocarcinoma), H322 (adenocarcinoma), or H157 (squamous) cells^[1]
Dosage:	10 mg/kg
Administration:	Intraperitoneal injection; 10 mg/kg; 3 times per week
Result:	Repressed PY-STAT3 levels stimulated by IL-6 in H322 cells. Repressed PY-STAT3 levels in H1650 cells. Inhibited the growth of tumors with H322 and CAF cells. Inhibited the growth of tumors with H1650 and CAF cells.

Animal Model:	Female NOD-SCID mice with MCF-7 tumor^[4]
Dosage:	20 mg/kg
Administration:	Intraperitoneal injection; 20 mg/kg; twice per week; 6 weeks
Result:	Blocked MCF-7 engraftment, induced regressions in 90% of tumors.

Drug interactions

Potentially hazardous interactions with other drugs
Live vaccines: risk of generalised infections - avoid.
Ciclosporin and tacrolimus: monitor levels on
initiation and discontinuation of siltuximab as it may reduce the activity of CYP450.

Metabolism

As siltuximab is a monoclonal antibody, the expected consequence of metabolism is proteolytic degradation to small peptides and individual amino acids, and receptormediated clearance.

Siltuximab Preparation Products And Raw materials

Raw materials

Preparation Products

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Siltuximab Suppliers

China 25 India 1 United States 2 Global 28

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541502-14-1, SiltuximabRelated Search:

Tanezumab belimumab Solanezumab Drozitumab Fresolimumab Seribantumab Inebilizumab Brazikumab Ulocuplumab IMMunoglobulin G2

Siltuximab

Research Grade Siltuximab(DHC15801)

Siltuximab (anti-IL-6)

CNTO-328

Research Grade Siltuximab

541502-14-1