IMMunoglobulin G2
- Product Name
- IMMunoglobulin G2
- CAS No.
- 1129435-60-4
- Chemical Name
- IMMunoglobulin G2
- Synonyms
- Gevokizumab;IMMunoglobulin G2;Gevokizumab (anti-IL-1b);Research Grade Gevokizumab;Research Grade Gevokizumab(DHB95602)
- CBNumber
- CB92563209
- Formula Weight
- 0
- MOL File
- Mol file
IMMunoglobulin G2 Property
- form
- Liquid
- color
- Colorless to light yellow
N-Bromosuccinimide Price
- Product number
- 140771
- Product name
- Immunoglobulin G2
- Packaging
- 200ul
- Price
- $436
- Updated
- 2021/12/16
IMMunoglobulin G2 Chemical Properties,Usage,Production
Uses
Gevokizumab is a potent anti-IL-1β antibody, negatively modulates IL-1β signaling through an allosteric mechanism. Gevokizumab selectively decreases the binding affinity of IL-1β for the IL-1 receptor type I (IL-1RI) signaling receptor instead of IL-1 counter-regulatory decoy receptor (IL-1 receptor type II)[1][2].
in vivo
Gevokizumab (1 mg/kg; i.v.; once daily for 3 d) improves endothelial regrowth and reduces neointima formation in rats following carotid denudation[2].
| Animal Model: | Rat carotid denudation model in Sprague-Dawley rats (3-month0-old, 330-360 g)[2] |
| Dosage: | 1, 10 and 50 mg/kg |
| Administration: | Intravenous injection; once daily for 3 days |
| Result: | Decreased carotid intima-media thickness (IMT) in the proximal part of the denuded artery at day 28, and improved endothelial regrowth at 1 mg/kg.? |
References
[1] Issafras H, et al. Detailed mechanistic analysis of gevokizumab, an allosteric anti-IL-1β antibody with differential receptor-modulating properties. J Pharmacol Exp Ther. 2014 Jan;348(1):202-15. DOI:10.1124/jpet.113.205443
[2] Roubille F, et al. The interleukin-1β modulator gevokizumab reduces neointimal proliferation and improves reendothelialization in a rat carotid denudation model. Atherosclerosis. 2014 Oct;236(2):277-85. DOI:10.1016/j.atherosclerosis.2014.07.012
IMMunoglobulin G2 Preparation Products And Raw materials
Raw materials
Preparation Products
IMMunoglobulin G2 Suppliers
- Tel
- 027-65317797 15926423062
- Fax
- QQ：422450190
- 422450190@qq.com
- Country
- China
- ProdList
- 10308
- Advantage
- 58
- Tel
- 0086-21-67651709
- Fax
- 0086-21-67651705
- cfx759@hotmail.com
- Country
- China
- ProdList
- 410
- Advantage
- 57
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 71826
- Advantage
- 60
- Tel
- 177-54423994 17754423994
- Fax
- QQ:2853530913
- 2853530910@QQ.com
- Country
- China
- ProdList
- 8000
- Advantage
- 62
- Tel
- 15817493340
- 981810490@qq.com
- Country
- China
- ProdList
- 1566
- Advantage
- 58
- Tel
- 027-65279366 18108604356
- products@biolabreagent.com
- Country
- China
- ProdList
- 9868
- Advantage
- 58
- Tel
- 13720134139 086-15871494362 13720134139
- orders@jknbiochem.com
- Country
- China
- ProdList
- 6762
- Advantage
- 58
- Tel
- 021-65675885 18964387627
- customer_service@efebio.com
- Country
- China
- ProdList
- 11973
- Advantage
- 58
- Tel
- 400-6206333 13167063860
- anhua.mao@aladdin-e.com
- Country
- China
- ProdList
- 48457
- Advantage
- 58
- Tel
- 17721492509; 17721492509
- 643638326@qq.com
- Country
- China
- ProdList
- 4970
- Advantage
- 58