Cinpanemab

Product Name: Cinpanemab
CAS No.: 2094516-02-4
Chemical Name: Cinpanemab
Synonyms: BIIB054;Cinpanemab;Research Grade Cinpanemab;Cinpanemab (anti-Alpha-synuclein);Research Grade Cinpanemab(DHE22001)
CBNumber: CB88081153
Formula Weight: 0
MOL File: Mol file

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Cinpanemab Property

form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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Cinpanemab Chemical Properties,Usage,Production

Uses

Cinpanemab (BIIB054) is a human-derived monoclonal antibody that binds to α-synuclein. Cinpanemab can be used for the research of Parkinson's disease[1][2].

in vivo

Cinpanemab (30 mg/kg; i.p.) improves PD-like phenotypes in α-syn PFF inoculation mouse models ^[2].

Animal Model:	C57BL/6JRccHsd WT mice, transgenic M83 mice expressing human α-syn A53T, and transgenic bacterial artificial chromosome mice expressing human α-syn A53T were anesthetized and stereotaxically injected with α-syn preformed fibrils (PFFs) into the right forebrain^[2]
Dosage:	30 mg/kg
Administration:	Intraperitoneal (i.p.) injections 2-3 times prior to α-syn PFF injection and weekly post-injection until time of sacrifice
Result:	Attenuated the spreading of α-syn pathology, rescued motor impairments, and reduced the loss of dopamine transporter density in dopaminergic terminals in striatum.

IC 50

α-synuclein

References

[1] Lang AE, et, al. Trial of Cinpanemab in Early Parkinson's Disease. N Engl J Med. 2022 Aug 4;387(5):408-420. DOI:10.1056/NEJMoa2203395
[2] Teng JS, et, al. Immunotherapies for Parkinson's Disease: Progression of Clinical Development. CNS Neurol Disord Drug Targets. 2021;20(9):802-813. DOI:10.2174/1871527320666210526160926

Cinpanemab Preparation Products And Raw materials

Raw materials

Preparation Products

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Cinpanemab Suppliers

China 19 United States 1 Global 20

Shanghai YuanYe Biotechnology Co., Ltd.

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2094516-02-4, CinpanemabRelated Search:

Cobolimab bimekizumab Vedolizumab Polatuzumab vedotin Cofetuzumab Cusatuzumab Tinurilimab Dacliximab Otelixizumab Gatralimab

Cinpanemab

Research Grade Cinpanemab(DHE22001)

Cinpanemab (anti-Alpha-synuclein)

BIIB054

Research Grade Cinpanemab

2094516-02-4