ChemicalBook > CAS DataBase List > 4-Methylhistamine dihydrochloride

4-Methylhistamine dihydrochloride

Product Name
4-Methylhistamine dihydrochloride
CAS No.
36376-47-3
Chemical Name
4-Methylhistamine dihydrochloride
Synonyms
SKF-71517;4-Methylhistamine di;4-Methylhistamine DiHCl;4-METHYLHISTAMINE DIHYDROCHLORIDE;5-Methylhistamine dihydrochloride;4-Methylhistamine (hydrochloride);Methylhistamine dihydrochloride, 4-;2-(4-methyl-1H-imidazol-5-yl)ethanamine;5-Methyl-1H-imidazole-4-ethanamine dihydrochloride;4-(2-Aminoethyl)-5-methylimidazole dihydrochloride
CBNumber
CB9838358
Molecular Formula
C6H14Cl2N3
Formula Weight
199.10146
MOL File
36376-47-3.mol
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4-Methylhistamine dihydrochloride Property

Melting point:
231-233℃ (ethanol )
storage temp. 
Desiccate at RT
solubility 
DMSO (Slightly, Heated), Methanol (Slightly)
form 
Solid
color 
White to Pale Beige
Water Solubility 
Soluble to 50 mM in water
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Safety

HazardClass 
IRRITANT
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
23761
Product name
4-Methylhistamine (hydrochloride)
Purity
≥95%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
23761
Product name
4-Methylhistamine (hydrochloride)
Purity
≥95%
Packaging
5mg
Price
$116
Updated
2024/03/01
Cayman Chemical
Product number
23761
Product name
4-Methylhistamine (hydrochloride)
Purity
≥95%
Packaging
10mg
Price
$199
Updated
2024/03/01
Tocris
Product number
2342
Product name
4-Methylhistaminedihydrochloride
Packaging
10
Price
$216
Updated
2021/12/16
Tocris
Product number
2342
Product name
4-Methylhistaminedihydrochloride
Packaging
50
Price
$908
Updated
2021/12/16
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4-Methylhistamine dihydrochloride Chemical Properties,Usage,Production

Description

4-Methylhistamine (dihydrochloride) is the potent agonist of histamine 4 receptor (H4R). 4-Methylhistamine (dihydrochloride) has the potential for the research of immune-related diseases such as cancer and autoimmune disorders.

Uses

Histamine H2 receptor agonist, antagonist and antineoplastic agent on the in vitro growth of peripheral blood CFU-GM from normal individuals and HL-60 leukemia cells.

Biological Activity

4-Methylhistamine dihydrochloride is a potent, high affinity H4 receptor agonist (Ki = 7 nM) that displays > 100-fold selectivity over other human histamine receptor subtypes.

storage

Desiccate at RT

References

[1]. lim hd, van rijn rm, ling p, et al. evaluation of histamine h1-, h2-, and h3-receptor ligands at the human histamine h4 receptor: identification of 4-methylhistamine as the first potent and selective h4 receptor agonist. journal of pharmacology and experimental therapeutics, 2005, 314(3): 1310-1321.
[2]. ahmad sf, ansari ma, zoheir kma, et al. regulation of tnf-α and nf-κb activation through the jak/stat signaling pathway downstream of histamine 4 receptor in a rat model of lps-induced joint inflammation. immunobiology, 2015, 220(7): 889-898.

4-Methylhistamine dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Methylhistamine dihydrochloride Suppliers

Canada 1 China 30 Germany 2 India 1 South Korea 1 The Netherlands 1 United Kingdom 1 United States 9 Global 46
Axon Medchem BV
Tel
--
Fax
--
Email
info@axonmedchem.com
Country
The Netherlands
ProdList
477
Advantage
30

36376-47-3, 4-Methylhistamine dihydrochlorideRelated Search:

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  • 4-(2-Aminoethyl)-5-methylimidazole dihydrochloride
  • 5-Methyl-1H-imidazole-4-ethanamine dihydrochloride
  • 5-Methylhistamine dihydrochloride
  • Imidazole, 4-(2-aminoethyl)-5-methyl-, dihydrochloride
  • 2-(4-methyl-1H-imidazol-5-yl)ethanamine dihydrochloride
  • 2-(5-Methyl-1H-iMidazol-4-yl)ethanaMine dihydrochloride
  • 2-(5-Methyl-4-imidazolyl)ethylamine dihydrochloride
  • 2-(4-methyl-1H-imidazol-5-yl)ethanamine
  • 4-Methylhistamine (hydrochloride)
  • 4-Methylhistamine DiHCl
  • Methylhistamine dihydrochloride, 4-
  • 4-Methylhistamine di
  • 36376-47-3
  • Histamine receptor
  • Amines
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals