ChemicalBook > CAS DataBase List > Methyl 5-nitro-2-methylbenzoate

Methyl 5-nitro-2-methylbenzoate

Product Name
Methyl 5-nitro-2-methylbenzoate
CAS No.
77324-87-9
Chemical Name
Methyl 5-nitro-2-methylbenzoate
Synonyms
Methyl 5-nitro-2-met;Methyl 5-Nitro-o-toluate;Lenalidomide Impurity 57;Methyl 5-nitro-2-methylbenzoate;Methyl 2-methyl-5-nitrobenzoate;Methyl2-Methyl-5-nitrobenzoate>5-Nitro-o-toluic acid methyl ester;o-Toluic acid, 5-nitro-, methyl ester;Methyl 2-methyl-5-nitrobenzoate, 98%,;5-Nitro-o-toluicacidmethylester(COOCH3=1)
CBNumber
CB9855131
Molecular Formula
C9H9NO4
Formula Weight
195.17
MOL File
77324-87-9.mol
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Methyl 5-nitro-2-methylbenzoate Property

Melting point:
67.0 to 71.0 °C
Boiling point:
305.4±22.0 °C(Predicted)
Density 
1?+-.0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
soluble in Methanol
form 
powder to crystal
color 
Light orange to Yellow to Green
CAS DataBase Reference
77324-87-9(CAS DataBase Reference)
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Safety

HS Code 
2916399090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

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N-Bromosuccinimide Price

TCI Chemical
Product number
M2220
Product name
Methyl 2-Methyl-5-nitrobenzoate
Purity
>98.0%(GC)
Packaging
5g
Price
$38
Updated
2025/07/31
TCI Chemical
Product number
M2220
Product name
Methyl 2-Methyl-5-nitrobenzoate
Purity
>98.0%(GC)
Packaging
25g
Price
$104
Updated
2025/07/31
ChemScene
Product number
CS-W019818
Product name
o-Toluicacid,5-nitro-,methylester
Packaging
25g
Price
$30
Updated
2021/12/16
AK Scientific
Product number
B357
Product name
Methyl5-nitro-2-methylbenzoate
Packaging
100g
Price
$147
Updated
2021/12/16
ChemScene
Product number
CS-W019818
Product name
o-Toluicacid,5-nitro-,methylester
Packaging
100g
Price
$105
Updated
2021/12/16
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Methyl 5-nitro-2-methylbenzoate Chemical Properties,Usage,Production

Chemical Properties

White crystalline powder

Synthesis

1975-52-6

74-88-4

77324-87-9

4.2.1 Synthesis of methyl 2-methyl-5-nitrobenzoate (2): 2-methyl-5-nitrobenzoic acid (15 g, 82.8 mmol) and potassium carbonate (K2CO3, 17.2 g, 124.2 mmol) were suspended in N,N-dimethylformamide (DMF, 75 mL) in a dry round-bottom flask. To this suspension, iodomethane (6.7 mL) was slowly added dropwise at room temperature. The reaction mixture was stirred at room temperature overnight (~12 hours). After completion of the reaction, the mixture was poured into water (500 mL) and the aqueous phase was extracted three times with ethyl acetate (EA). The organic phases were combined, dried with anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure to give methyl 2-methyl-5-nitrobenzoate (15.3 g, 94% yield) as a yellow solid. The product was confirmed by 1H NMR (400 MHz, CDCl3): δ 8.52 (s, 1H), 8.05 (s, 1H), 7.30 (s, 1H), 3.83 (s, 3H), 2.56 (s, 3H). ESI-MS analysis showed m/z 196 [M + H]+.

References

[1] Journal of the American Chemical Society, 2003, vol. 125, # 40, p. 12074 - 12075
[2] Patent: US6344465, 2002, B1. Location in patent: Page column 32
[3] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 17, p. 5881 - 5890
[4] Patent: US2005/43385, 2005, A1. Location in patent: Page/Page column 14
[5] Patent: US2001/34343, 2001, A1

Methyl 5-nitro-2-methylbenzoate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Methyl 5-nitro-2-methylbenzoate manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
Methyl 5-nitro-2-methylbenzoate 77324-87-9
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
10000KGS
Release date
2025-05-13
Henan Fengda Chemical Co., Ltd
Product
Methyl 5-nitro-2-methylbenzoate 77324-87-9
Price
US $100.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-25
Shaanxi Dideu Medichem Co. Ltd
Product
Methyl 2-Methyl-5-nitrobenzoate 77324-87-9
Price
US $0.00-0.00/Kg
Min. Order
1KG
Purity
99.0%
Supply Ability
100 tons
Release date
2020-01-10

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  • 77324-87-9