Methyl 5-nitro-2-methylbenzoate

Product Name: Methyl 5-nitro-2-methylbenzoate
CAS No.: 77324-87-9
Chemical Name: Methyl 5-nitro-2-methylbenzoate
Synonyms: Methyl 5-nitro-2-met;Methyl 5-Nitro-o-toluate;Lenalidomide Impurity 57;Methyl 5-nitro-2-methylbenzoate;Methyl 2-methyl-5-nitrobenzoate;Methyl2-Methyl-5-nitrobenzoate>5-Nitro-o-toluic acid methyl ester;o-Toluic acid, 5-nitro-, methyl ester;Methyl 2-methyl-5-nitrobenzoate, 98%,;5-Nitro-o-toluicacidmethylester(COOCH3=1)
CBNumber: CB9855131
Molecular Formula: C9H9NO4
Formula Weight: 195.17
MOL File: 77324-87-9.mol

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Methyl 5-nitro-2-methylbenzoate Property

Melting point:: 67.0 to 71.0 °C
Boiling point:: 305.4±22.0 °C(Predicted)
Density: 1?+-.0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: soluble in Methanol
form: powder to crystal
color: Light orange to Yellow to Green
CAS DataBase Reference: 77324-87-9(CAS DataBase Reference)

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Safety

HS Code: 2916399090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

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N-Bromosuccinimide Price

TCI Chemical

Product number: M2220
Product name: Methyl 2-Methyl-5-nitrobenzoate
Purity: >98.0%(GC)
Packaging: 5g
Price: $38
Updated: 2025/07/31

TCI Chemical

Product number: M2220
Product name: Methyl 2-Methyl-5-nitrobenzoate
Purity: >98.0%(GC)
Packaging: 25g
Price: $104
Updated: 2025/07/31

ChemScene

Product number: CS-W019818
Product name: o-Toluicacid,5-nitro-,methylester
Packaging: 25g
Price: $30
Updated: 2021/12/16

AK Scientific

Product number: B357
Product name: Methyl5-nitro-2-methylbenzoate
Packaging: 100g
Price: $147
Updated: 2021/12/16

ChemScene

Product number: CS-W019818
Product name: o-Toluicacid,5-nitro-,methylester
Packaging: 100g
Price: $105
Updated: 2021/12/16

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Methyl 5-nitro-2-methylbenzoate Chemical Properties,Usage,Production

Chemical Properties

White crystalline powder

Synthesis

1975-52-6

74-88-4

77324-87-9

4.2.1 Synthesis of methyl 2-methyl-5-nitrobenzoate (2): 2-methyl-5-nitrobenzoic acid (15 g, 82.8 mmol) and potassium carbonate (K2CO3, 17.2 g, 124.2 mmol) were suspended in N,N-dimethylformamide (DMF, 75 mL) in a dry round-bottom flask. To this suspension, iodomethane (6.7 mL) was slowly added dropwise at room temperature. The reaction mixture was stirred at room temperature overnight (~12 hours). After completion of the reaction, the mixture was poured into water (500 mL) and the aqueous phase was extracted three times with ethyl acetate (EA). The organic phases were combined, dried with anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure to give methyl 2-methyl-5-nitrobenzoate (15.3 g, 94% yield) as a yellow solid. The product was confirmed by 1H NMR (400 MHz, CDCl3): δ 8.52 (s, 1H), 8.05 (s, 1H), 7.30 (s, 1H), 3.83 (s, 3H), 2.56 (s, 3H). ESI-MS analysis showed m/z 196 [M + H]+.

References

[1] Journal of the American Chemical Society, 2003, vol. 125, # 40, p. 12074 - 12075
[2] Patent: US6344465, 2002, B1. Location in patent: Page column 32
[3] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 17, p. 5881 - 5890
[4] Patent: US2005/43385, 2005, A1. Location in patent: Page/Page column 14
[5] Patent: US2001/34343, 2001, A1

Methyl 5-nitro-2-methylbenzoate Preparation Products And Raw materials

Raw materials

Preparation Products

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Methyl 5-nitro-2-methylbenzoate Suppliers

Americas 1 Belgium 1 China 153 Europe 1 France 2 Germany 5 India 16 Japan 1 The Netherlands 1 Ukraine 2 United Kingdom 6 United States 34 Global 223

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View Lastest Price from Methyl 5-nitro-2-methylbenzoate manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: Methyl 5-nitro-2-methylbenzoate 77324-87-9
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 10000KGS
Release date: 2025-05-13

Henan Fengda Chemical Co., Ltd

Product: Methyl 5-nitro-2-methylbenzoate 77324-87-9
Price: US $100.00-1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-25

Shaanxi Dideu Medichem Co. Ltd

Product: Methyl 2-Methyl-5-nitrobenzoate 77324-87-9
Price: US $0.00-0.00/Kg
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 100 tons
Release date: 2020-01-10

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77324-87-9