Methyl 5-nitro-2-methylbenzoate
- Product Name
- Methyl 5-nitro-2-methylbenzoate
- CAS No.
- 77324-87-9
- Chemical Name
- Methyl 5-nitro-2-methylbenzoate
- Synonyms
- Methyl 5-nitro-2-met;Methyl 5-Nitro-o-toluate;Lenalidomide Impurity 57;Methyl 5-nitro-2-methylbenzoate;Methyl 2-methyl-5-nitrobenzoate;Methyl2-Methyl-5-nitrobenzoate>5-Nitro-o-toluic acid methyl ester;o-Toluic acid, 5-nitro-, methyl ester;Methyl 2-methyl-5-nitrobenzoate, 98%,;5-Nitro-o-toluicacidmethylester(COOCH3=1)
- CBNumber
- CB9855131
- Molecular Formula
- C9H9NO4
- Formula Weight
- 195.17
- MOL File
- 77324-87-9.mol
Methyl 5-nitro-2-methylbenzoate Property
- Melting point:
- 67.0 to 71.0 °C
- Boiling point:
- 305.4±22.0 °C(Predicted)
- Density
- 1?+-.0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- form
- powder to crystal
- color
- Light orange to Yellow to Green
- CAS DataBase Reference
- 77324-87-9(CAS DataBase Reference)
Safety
- HS Code
- 2916399090
N-Bromosuccinimide Price
- Product number
- M2220
- Product name
- Methyl 2-Methyl-5-nitrobenzoate
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $38
- Updated
- 2025/07/31
- Product number
- M2220
- Product name
- Methyl 2-Methyl-5-nitrobenzoate
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $104
- Updated
- 2025/07/31
- Product number
- B357
- Product name
- Methyl5-nitro-2-methylbenzoate
- Packaging
- 1g
- Price
- $14
- Updated
- 2021/12/16
- Product number
- CS-W019818
- Product name
- o-Toluicacid,5-nitro-,methylester
- Packaging
- 25g
- Price
- $30
- Updated
- 2021/12/16
- Product number
- 210253
- Product name
- Methyl 2-Methyl-5-nitrobenzoate
- Purity
- 97%
- Packaging
- 25g
- Price
- $44
- Updated
- 2021/12/16
Methyl 5-nitro-2-methylbenzoate Chemical Properties,Usage,Production
Chemical Properties
White crystalline powder
Synthesis
1975-52-6
74-88-4
77324-87-9
4.2.1 Synthesis of methyl 2-methyl-5-nitrobenzoate (2): 2-methyl-5-nitrobenzoic acid (15 g, 82.8 mmol) and potassium carbonate (K2CO3, 17.2 g, 124.2 mmol) were suspended in N,N-dimethylformamide (DMF, 75 mL) in a dry round-bottom flask. To this suspension, iodomethane (6.7 mL) was slowly added dropwise at room temperature. The reaction mixture was stirred at room temperature overnight (~12 hours). After completion of the reaction, the mixture was poured into water (500 mL) and the aqueous phase was extracted three times with ethyl acetate (EA). The organic phases were combined, dried with anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure to give methyl 2-methyl-5-nitrobenzoate (15.3 g, 94% yield) as a yellow solid. The product was confirmed by 1H NMR (400 MHz, CDCl3): δ 8.52 (s, 1H), 8.05 (s, 1H), 7.30 (s, 1H), 3.83 (s, 3H), 2.56 (s, 3H). ESI-MS analysis showed m/z 196 [M + H]+.
References
[1] Journal of the American Chemical Society, 2003, vol. 125, # 40, p. 12074 - 12075
[2] Patent: US6344465, 2002, B1. Location in patent: Page column 32
[3] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 17, p. 5881 - 5890
[4] Patent: US2005/43385, 2005, A1. Location in patent: Page/Page column 14
[5] Patent: US2001/34343, 2001, A1
Methyl 5-nitro-2-methylbenzoate Preparation Products And Raw materials
Raw materials
Preparation Products
Methyl 5-nitro-2-methylbenzoate Suppliers
- Tel
- 03-36680489
- Fax
- 03-3668-0520
- Sales-JP@TCIchemicals.com
- Country
- Japan
- ProdList
- 28387
- Advantage
- 80
View Lastest Price from Methyl 5-nitro-2-methylbenzoate manufacturers
- Product
- Methyl 5-nitro-2-methylbenzoate 77324-87-9
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-13
- Product
- Methyl 5-nitro-2-methylbenzoate 77324-87-9
- Price
- US $100.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-25
- Product
- Methyl 2-Methyl-5-nitrobenzoate 77324-87-9
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 100 tons
- Release date
- 2020-01-10