proquazone Property

Melting point:

137-138°

Boiling point:

436.12°C (rough estimate)

Density 

1.1707 (rough estimate)

refractive index 

1.5700 (estimate)

pka

0.74±0.20(Predicted)

Hazard and Precautionary Statements (GHS)

proquazone Chemical Properties,Usage,Production

Uses

Anti-inflammatory.

Uses

Proquazone is a non-steroidal anti-inflammatory drug.

Definition

ChEBI: Proquazone is a member of pyrimidines.

brand name

Arthrex (Novartis), Biarison (Swiss-Pharma, Egypt; Biochemie, Austria; ICN Alkaloida, Hungary; Sandoz, Finland, Turkey).

Clinical Use

Proquazone has been used successfully to treat rheumatoid polyarthritis. At 900 mg/d it is comparable in effect to 150 mg/d of indomethacin. Gastrointestinal disturbances are the principal adverse effects observed with its use.

Synthesis

Synthesis: proquazone is prepared by the alkylation of 2-amino-4-methylbenzophenone with 2-iodopropane in the presence of sodium carbonate to give 4-methyl-2-[(1- methylethyl)amino]benzophenone, which is condensed with urethane in the presence of zinc chloride at 190 ?C.