TIROFIBAN HYDROCHLORIDE MONOHYDRATE
TIROFIBAN HYDROCHLORIDE MONOHYDRATE Basic information
- Product Name:
- TIROFIBAN HYDROCHLORIDE MONOHYDRATE
- Synonyms:
-
- L 700462
- L-Tyrosine, N-(butylsulfonyl)-o-(4-(4-piperidinyl)butyl)-, monohydrochloride
- N-(Butylsulfonyl)-o-(4-(4-piperidinyl)butyl)-L-tyrosine monohydrochloride
- 2-(butylsulfonaMido)-3-(4-(4-(piperidin-4-yl)butoxy)phenyl)propanoic acid
- L-Tyrosine,N-(butylsulfonyl)-O-[4-(4-piperidinyl)butyl]-, hydrochloride (1:1)
- -3-(4-(4-(piperidin-4-yl)
- butoxy)
- N-(Butylsulfonyl)-O-[4-(4-piperidinyl)butyl]-L-tyrosine hydrochloride
- CAS:
- 142373-60-2
- MF:
- C22H39ClN2O6S
- MW:
- 495.07
- Mol File:
- 142373-60-2.mol
TIROFIBAN HYDROCHLORIDE MONOHYDRATE Chemical Properties
- Melting point:
- 83-87oC
- solubility
- Methanol (Slightly)
- form
- Solid
- color
- White
- CAS DataBase Reference
- 142373-60-2
TIROFIBAN HYDROCHLORIDE MONOHYDRATE Usage And Synthesis
Description
Tirofiban was launched as Aggrastat in Switzerland and the US for patients with unstable angina or non-Q-wave myocardial infarction to prevent cardiac ischemic events. Tirofiban is synthesized from (S)-tyrosine by a fourstep process. Tirofiban is a novel highly potent antiplatelet agent that inhibits the interaction of fibrinogen with GPⅡb/Ⅲa, an activated platelet membrane-bound glycoprotein complex. It prevents arterial thrombus formation in a dosedependent manner. Clinical efficacy was highly significant with an absolute and relative risk reduction. In these studies, treatment with tirofiban was well tolerated, without significant adverse effects.
Originator
Sibutramine (Sibutramine)
Uses
Aggrastat (Millot Laboratories, France).
Uses
Tirofiban Hydrochloride is a selective nonpeptide platelet glycoprotein IIb/IIIa antagonist.
Manufacturing Process
The synthesis of tirofiban starts by reaction of tyrosine with bis-trimethylsilyl trifluoraceramide to give a derivative in which both functions -OH and COOH_x0002_are protected. Treatment of this intermediate with butylsulfonyl chloride gives the corresponding sulfonamide derivative; the quite labile silyl groups are then removed under mildly acidic conditions to give N-butylsulfonyl-tyrosine. In a parallel scheme, 4-picoline is converted to its anion by means of butyl lithium; this gives 4-(4-chlorobutyl)-pyridine on alkylation with 1-bromo-3- chloropropane. The reaction of this compound with N-butylsulfonyl-tyrosine in presence of NaOH gives the ether 2-butylsulfonyaminol-3-[4-pyridin-4-ylbutoxy-phenyl]propionic acid. Hydrogenation over palladium on charcoal then reduce the pyridine ring to a piperidine to afford the fibrinogen receptor antagonist tirofiban.
brand name
Tirofiban is INN and BAN.
Therapeutic Function
Fibrinogen receptor antagonist
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TIROFIBAN HYDROCHLORIDE MONOHYDRATE(142373-60-2)Related Product Information
- Tirofiban hydrochloride monohydrate
- L-N-BUTYLSULFONYL-P-HYDROXYPHENYLALANINE
- Tirofiban IMpurity (4,4'-Dipyridyl-1,5-Pentane)
- tirofiban
- N-Butylsulfonyl-O-(4-(4-pyridinyl)butyl)-L-tyrosine
- 4-PYRIDIN-4-YL-BUTAN-1-OL
- 1-Butanesulfonic acid methyl ester
- 4-PYRIDIN-4-YL-BUTYRIC ACID
- Sodium 1-butanesulfonate
- 1-Methylethyl 1-butanesulfonate
- METHYL N-BUTYLSULFONYL-L-P-HYDROXYPHENYLALANINE
- tirofiban
- tirofiban
- 1-Butanesulfonyl chloride
- 4-(4-Piperidyl)-1-butanol
- 2-butyl-4-methylpyridine
- 4,4'-Dimethyl-2,2'-bipyridyl
- 4-Chloro-1-butanol