4-(3-fluoro-benzyloxy)-benzaldehyde Chemical Properties

Melting point:

46.0 to 50.0 °C

Boiling point:

265°C/3mmHg(lit.)

Density 

1.211±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

solubility 

soluble in Methanol

form 

Solid:crystalline

color 

White to Almost white

InChI

InChI=1S/C14H11FO2/c15-13-3-1-2-12(8-13)10-17-14-6-4-11(9-16)5-7-14/h1-9H,10H2

InChIKey

DNKSIIHRKWTIRH-UHFFFAOYSA-N

SMILES

C(=O)C1=CC=C(OCC2=CC=CC(F)=C2)C=C1

CAS DataBase Reference

66742-57-2

Safety Information

HS Code 

2913.00.4000

HazardClass 

IRRITANT

4-(3-fluoro-benzyloxy)-benzaldehyde Usage And Synthesis

Chemical Properties

4-(3-fluorobenzyloxy)benzaldehyde is white to off-white solid at room temperature and pressure, it is a benzaldehyde derivative, and it is easy to be oxidized by air to produce the corresponding benzoic acid compounds when stored for a long time at room temperature, therefore, it is generally required to be stored under low temperature (2 to 8 degrees).

Uses

4-(3-Fluorobenzyloxy)benzaldehyde is useful for organic reactions and synthesis.

Synthesis

4-(3-fluoro-benzyloxy)-benzaldehyde is synthesized by the reaction of 4-Hydroxybenzaldehyde with 3-fluorobenzyl bromide. 4-Hydroxybenzaldehyde, 3-fluorobenzyl bromide, potassium carbonate, and acetone were sequentially added to a single-neck round bottom flask. Reaction at 60 ° C for 5 h. Cool to room temperature, filter, and collect the filtrate.Purification by direct column chromatography. 4-(3-fluoro-benzyloxy)-benzaldehyde was obtained as a white solid (1.78 g, 94.4%).

References

[1] Patent: WO2009/74478, 2009, A1. Location in patent: Page/Page column 80-81
[2] Patent: WO2009/74478, 2009, A1. Location in patent: Page/Page column 81
[3] Patent: WO2007/147491, 2007, A1. Location in patent: Page/Page column 44-45
[4] Patent: WO2009/74478, 2009, A1. Location in patent: Page/Page column 57-58
[5] Patent: CN106220525, 2016, A. Location in patent: Paragraph 0013; 0014; 0019

4-(3-fluoro-benzyloxy)-benzaldehyde(66742-57-2)Related Product Information

• 3-BROMO-4-[(3-FLUOROBENZYL)OXY]-5-METHOXYBENZALDEHYDE
• 4-[(3-FLUOROBENZYL)OXY]-3-METHOXYBENZALDEHYDE
• 4'-(3-FLUOROBENZYLOXY)ACETOPHENONE
• 4-(3-fluoro-benzyloxy)-benzaldehyde
• 4-[(3-FLUOROBENZYL)OXY]BENZENECARBOXYLIC ACID
• 4-[(3-FLUOROBENZYL)OXY]BENZENECARBOHYDRAZIDE
• 3-ETHOXY-4-[(3-FLUOROBENZYL)OXY]BENZALDEHYDE
• METHYL 4-[(3-FLUOROBENZYL)OXY]BENZENECARBOXYLATE
• AURORA 17105
• RARECHEM AL BI 1117
• AURORA 17115
• AURORA 17106
• AURORA 17544
• AURORA 17119
• RARECHEM AL BE 1117
• 4-[(3,5-DIFLUOROBENZYL)OXY]BENZALDEHYDE
• SPECS AG-690/15444714
• RARECHEM AL BF 1117