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3-ACETAMIDOPHENOL

Basic information Safety Supplier Related

3-ACETAMIDOPHENOL Basic information

Product Name:
3-ACETAMIDOPHENOL
Synonyms:
  • N-(3-HYDROXYPHENYL)ACETAMIDE
  • M-HYDROXYACETANILIDE
  • 3-(Acetylamino)-1-hydroxybenzene
  • 3-(Acetylamino)phenol
  • 3’-hydroxy-acetanilid
  • 3-Hydroxy-4-trimethylammoniobutanoate3'-hydroxyacetanilide
  • Acetamide, N-(3-hydroxyphenyl)-
  • Acetanilide, 3'-hydroxy-
CAS:
621-42-1
MF:
C8H9NO2
MW:
151.16
EINECS:
210-687-0
Product Categories:
  • Aromatic Phenols
  • Phenol&Thiophenol&Mercaptan
  • Anilines, Amides & Amines
  • Phenols
Mol File:
621-42-1.mol
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3-ACETAMIDOPHENOL Chemical Properties

Melting point:
145-148 °C(lit.)
Boiling point:
273.17°C (rough estimate)
Density 
1.249
refractive index 
1.5810 (estimate)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
pka
9.50±0.10(Predicted)
form 
Crystals, Crystalline Powder or Needles
color 
Off-white to tan or light gray
PH
6-7 (H2O)(saturated solution)
BRN 
907998
CAS DataBase Reference
621-42-1(CAS DataBase Reference)
EPA Substance Registry System
3'-Hydroxyacetanilide (621-42-1)
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Safety Information

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38
Safety Statements 
26-36
RIDADR 
2811
WGK Germany 
2
RTECS 
AE4100000
1-8
Hazard Note 
Irritant
TSCA 
Yes
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29242995
Toxicity
LD50 intraperitoneal in mouse: 1025mg/kg

MSDS

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3-ACETAMIDOPHENOL Usage And Synthesis

Chemical Properties

off-white to tan or light grey crystals,

Uses

analgesic

Definition

ChEBI: A derivative of phenol which has an acetamido substituent located meta to the phenolic -OH group. It is a non-toxic regioisomer of paracetamol with analgesic properties, but has never been marketed as a drug.

General Description

Light gray solid.

Air & Water Reactions

Water insoluble.

Reactivity Profile

Phenols do not behave as organic alcohols, as one might guess from the presence of a hydroxyl (-OH) group in their structure. Instead, they react as weak organic acids. Phenols and cresols are much weaker as acids than common carboxylic acids (phenol has Ka = 1.3 x 10^[-10]). These materials are incompatible with strong reducing substances such as hydrides, nitrides, alkali metals, and sulfides. Flammable gas (H2) is often generated, and the heat of the reaction may ignite the gas. Heat is also generated by the acid-base reaction between phenols and bases. Phenols are sulfonated very readily (for example, by concentrated sulfuric acid at room temperature). The reactions generate heat. Phenols are also nitrated very rapidly, even by dilute nitric acid. Nitrated phenols often explode when heated. Many of them form metal salts that tend toward detonation by rather mild shock. Flammable gases are formed by the reaction of organic amides with strong reducing agents. Amides are very weak bases (weaker than water). Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).

Fire Hazard

Flash point data for 3-ACETAMIDOPHENOL are not available. 3-ACETAMIDOPHENOL is probably combustible.

Purification Methods

Recrystallise the phenol from water. The 3,5-dinitrobenzamide complex gives orange-yellow crystals from hot H2O and has m 212o. [Beilstein 13 H 415, 13 I 132, 13 II 213, 13 III 950, 13 IV 977.]

3-ACETAMIDOPHENOL Preparation Products And Raw materials

Preparation Products

3-ACETAMIDOPHENOLSupplier

J & K SCIENTIFIC LTD.
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3B Pharmachem (Wuhan) International Co.,Ltd.
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Alfa Aesar
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021-67121386 / 800-988-0390
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