Cefminox Chemical Properties

CAS DataBase Reference

75481-73-1(CAS DataBase Reference)

Cefminox Usage And Synthesis

Application

It is mainly used for sepsis, tonsillitis, bronchitis, pneumonia, lung abscess, pyelonephritis, cystitis, cholecystitis, peritonitis, pelvic inflammatory disease, adnexitis, endometritis, and postoperative infections caused by sensitive bacteria.

Definition

ChEBI: Cefminox is a second-generation cephamycin antibiotic having [(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl and 2-{[(2S)-2-amino-2-carboxyethyl]sulfanyl}acetamido side-groups located respectively at positions 3 and 7beta of the cephem nucleus. A broad-spectrum bactericide, it is especially effective against Gram-negative and anaerobic bacteria. It is a cephamycin and a member of tetrazoles. It is a conjugate acid of a cefminox(1-).

Antimicrobial activity

A semisynthetic cephamycin. Activity is similar to that of cefoxitin and cefotetan, but the activity against enterobacteria and B. fragilis is somewhat better . C. difficile is inhibited by 4–16 mg/L. It is stable to the common β-lactamases of enterobacteria and Bacteroides spp.
A 15-min intravenous infusion of 1 g achieves a serum concentration of 30 mg/L after 1 h. The plasma half-life is c. 2 h and around 68% is protein bound.
Its safety profile and uses are similar to those of other cephamycins. It is available in Japan.

Cefminox(75481-73-1)Related Product Information

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