Cephalosporins Drugs
Cephalosporins refer to a class of antibiotics using the natural cephalosporin C secreted by the cephalosporin coronary culture as raw materials. It is manufactured through semi-synthetic modification of the side chain of cephalosporin C, also belonging to β-lactam antibiotics. It is a family of broad-spectrum semi-synthetic bactericidal antibiotics. According to their different ages and different antimicrobial activity, they can be divided into first, second, third generations, including cephalosporin Ⅰ-Ⅷ, cefathiamidine, cefamandole, cefadroxil, ceftizoxime and cephamycin derivatives and moxalactam.
Antimicrobial spectrum
(1) First generation cephalosporins mainly have effects on β-hemolytic streptococci and other streptococci, staphylococci (including enzyme production strains), Haemophilus influenzae, Escherichia coli, Klebsiella, Salmonella and Shigella bacteria. This class of antibiotics has relative weak resistance against the β-lactamase produced by the gram-negative bacteria. Therefore it is easier for Gram-negative bacteria to develop resistance.
(2) Second-generation cephalosporins have comparable or slightly lower antimicrobial activity against gram-positive bacteria compared to the first generation of antimicrobial activity similar to or slightly lower than the first generation, while having excellent effects in inhibiting the Gram-negative bacteria, as follows:
① Strong anti-enzyme capability: some Gram-negative bacteria (such as E. coli) are easy to become resistant against the first-generation cephalosporin with the second generation often being effective;
② Broad antimicrobial spectrum, the second generation has a broader antimicrobial spectrum against the first generation antibacterial spectrum with certain antibacterial activity against Neisseria, a part of indole-positive Proteus, Citrobacter and Enterobacteriaceae.
(3) The effectiveness of third-generation cephalosporins in killing gram-positive bacteria are generally lower than the first generation while their effect against gram-negative bacteria is better than the second generation. The third generation cephalosporin has broader antibacterial spectrum and stronger resistance to the enzyme.
Toxic side effect
(1) Allergic reaction: it can cause skin rashes, asthma, angioedema, anaphylactic shock and so on. The anaphylactic shock of cephalosporins is similar to penicillin. These two types of drugs have varying degrees of cross-allergic reactions. In general, 10% to 30% of those who are allergic to penicillin are also allergic to the cephalosporin while the vast majority of cephalosporin-sensitive patients are also allergic to penicillin.
(2) Gastrointestinal reactions and dysbacteriosis: cephalosporins can cause nausea, vomiting, loss of appetite and other reactions. Second-generation and third-generation cephalosporins can strongly inhibit the intestinal flora, being able to lead to dysbacteriosis, even superinfection in severe cases.
(3) Liver toxicity: Most kinds of cephalosporins, when used in large dose, can cause elevated level of transaminase, alkaline phosphatase, bilirubin, and so on.
(4) Renal toxicity: Most kinds of cephalosporins can be excreted by the kidneys, and even can lead to elevated blood urea nitrogen level, oliguria and proteinuria. Its combination with furosemide and aminoglycoside antibiotics will lead to increased kidney damage.
(5) Coagulation disorders: cephalosporins can inhibit the intestinal flora to produce vitamin K, and therefore can potentially cause bleeding effect.
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- Structure:
- Chemical Name:
- (Z)-2-Amino-alpha-[1-(tert-butoxycarbonyl)]-1-methylethoxyimino-4-thiazolacetic acid
- CAS:
- 86299-47-0
- MF:
- C13H19N3O5S
- Structure:
- Chemical Name:
- TAEM
- CAS:
- 158183-05-2
- MF:
- C20H22N4O4S3
- Structure:
- Chemical Name:
- 2-Mercaptobenzothiazolyl-(Z)-(2-aminothiazol-4-yl)-2-(tert-butoxycarbonyl) isopropoxyiminoacetate
- CAS:
- 89604-92-2
- MF:
- C20H22N4O4S3
- Structure:
- Chemical Name:
- 7-Amino-3-cephem-4-carboxylic acid
- CAS:
- 36923-17-8
- MF:
- C7H8N2O3S
- Structure:
- Chemical Name:
- Ceftriaxone sodium
- CAS:
- 104376-79-6
- MF:
- C18H21N8NaO8S3
- Structure:
- Chemical Name:
- Ceftiofur
- CAS:
- 80370-57-6
- MF:
- C19H17N5O7S3
- Structure:
- Chemical Name:
- Cefeprime dihydrochloride
- CAS:
- 107648-80-6
- MF:
- C19H25ClN6O5S2
- Structure:
- Chemical Name:
- Cefoselis sulfate
- CAS:
- 122841-12-7
- MF:
- C19H24N8O10S3
- Structure:
- Chemical Name:
- Cemandil sodium salt
- CAS:
- 42540-40-9
- MF:
- C19H17N6NaO6S2
- Structure:
- Chemical Name:
- Ceftiofur hydrochloride
- CAS:
- 103980-44-5
- MF:
- C19H18ClN5O7S3
- Structure:
- Chemical Name:
- 7-Amino-3-vinyl-3-cephem-4-carboxylic acid diphenylmethyl ester monohydrochloride
- CAS:
- 79349-67-0
- MF:
- C22H21ClN2O3S
- Structure:
- Chemical Name:
- GCLH
- CAS:
- 64308-63-0
- MF:
- C29H25ClN2O4S
- Structure:
- Chemical Name:
- Ceftiofur sodium
- CAS:
- 104010-37-9
- MF:
- C19H18N5NaO7S3
- Structure:
- Chemical Name:
- Tilmicosin
- CAS:
- 108050-54-0
- MF:
- C46H80N2O13
- Structure:
- Chemical Name:
- CEFATHIAMIDINE
- CAS:
- 33075-00-2
- MF:
- C19H28N4O6S2
- Structure:
- Chemical Name:
- 7-Amino-3-chloro cephalosporanic acid
- CAS:
- 53994-69-7
- MF:
- C7H7ClN2O3S
- Structure:
- Chemical Name:
- 7-Aminocephalosporanic acid
- CAS:
- 957-68-6
- MF:
- C10H12N2O5S
- Structure:
- Chemical Name:
- Cefodizime sodium
- CAS:
- 86329-79-5
- MF:
- C20H21N6NaO7S4
- Structure:
- Chemical Name:
- Cephalexin
- CAS:
- 15686-71-2
- MF:
- C16H17N3O4S
- Structure:
- Chemical Name:
- Cefuroxime sodium
- CAS:
- 56238-63-2
- MF:
- C16H15N4O8S.Na
- Structure:
- Chemical Name:
- 7-ACT
- CAS:
- 131257-07-3
- MF:
- C12H13N5O5S2
- Structure:
- Chemical Name:
- Cefcapene pivoxil hydrochloride
- CAS:
- 147816-24-8
- MF:
- C23H32ClN5O9S2
- Structure:
- Chemical Name:
- Cefoselis
- CAS:
- 122841-10-5
- MF:
- C19H22N8O6S2
- Structure:
- Chemical Name:
- 2-[2-[[(Phenylmethoxy)carbonyl]amino]-4-thiazolyl]-2-pentenedioic acid 5-(3-methyl-2-butenyl) ester
- CAS:
- 115065-79-7
- MF:
- C21H22N2O6S
- Structure:
- Chemical Name:
- Cefotaxime sodium
- CAS:
- 64485-93-4
- MF:
- C16H18N5NaO7S2
- Structure:
- Chemical Name:
- S-2-BENZOTHIAZOLYL (Z)-2-(5-AMINO-1,2,4-THIADIAZOL-3-YL)-2-METHOXYIMINO THIOACETATE
- CAS:
- 104797-47-9
- MF:
- C14H10N4O3S3
- Structure:
- Chemical Name:
- Cefpirome
- CAS:
- 84957-29-9
- MF:
- C22H22N6O5S2
- Structure:
- Chemical Name:
- APRAMYCIN
- CAS:
- 37321-09-8
- MF:
- C21H41N5O11
- Structure:
- Chemical Name:
- Cefquinome sulfate
- CAS:
- 118443-89-3
- MF:
- C23H26N6O9S3
- Chemical Name:
- (Z)-2-(TERT-METHOXYCARBONYLMETHOXYIMINO)-2-(2-AMINOTHIAZOL-4-YL)ACETIC ACID
- CAS:
- 80554-17-8
- MF:
- C11H15N3O5S
- Structure:
- Chemical Name:
- 7-ACMA
- CAS:
- 79349-53-4
- MF:
- C21H20Cl2N2O3S
- Structure:
- Chemical Name:
- Sodium cefamandole
- CAS:
- 30034-03-8
- MF:
- C18H17N6NaO5S2
- Structure:
- Chemical Name:
- Cefozopran hydrochloride
- CAS:
- 113981-44-5
- MF:
- C19H18ClN9O5S2
- Structure:
- Chemical Name:
- CEPHALEXIN MONOHYDRATE
- CAS:
- 23325-78-2
- MF:
- C16H19N3O5S
- Structure:
- Chemical Name:
- Cefadroxil
- CAS:
- 66592-87-8
- MF:
- C16H17N3O5S.H2O
- Structure:
- Chemical Name:
- Cefixime
- CAS:
- 79350-37-1
- MF:
- C16H15N5O7S2
- Structure:
- Chemical Name:
- Latamoxef sodium
- CAS:
- 64953-12-4
- MF:
- C20H21N6NaO9S
- Structure:
- Chemical Name:
- (6R,7R)-7-Amino-8-oxo-3-(1-propenyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
- CAS:
- 120709-09-3
- MF:
- C10H12N2O3S
- Structure:
- Chemical Name:
- CEFOTAXIME
- MF:
- C16H17N5O7S2
- Chemical Name:
- PENICILLINASE
- CAS:
- 9012-26-4
- Structure:
- Chemical Name:
- ACECLIDINE HYDROCHLORIDE
- CAS:
- 6109-70-2
- MF:
- C9H16ClNO2
- Structure:
- Chemical Name:
- Cefotiam hydrochloride
- CAS:
- 66309-69-1
- MF:
- C18H23N9O4S3.HCl
- Structure:
- Chemical Name:
- Cefoxitin sodium
- CAS:
- 33564-30-6
- MF:
- C16H18N3NaO7S2
- Structure:
- Chemical Name:
- Ceftibuten dihydrate
- CAS:
- 118081-34-8
- MF:
- C15H16N4O7S2
- Structure:
- Chemical Name:
- 7-Aminodesacetoxycephalosporanic acid
- CAS:
- 26395-99-3
- MF:
- C8H10N2O3S
- Structure:
- Chemical Name:
- Cefditoren pivoxil
- CAS:
- 117467-28-4
- MF:
- C25H28N6O7S3
- Structure:
- Chemical Name:
- Cefazolin sodium salt
- CAS:
- 27164-46-1
- MF:
- C14H15N8NaO4S3
- Structure:
- Chemical Name:
- Cefdinir
- CAS:
- 91832-40-5
- MF:
- C14H13N5O5S2
- Chemical Name:
- Unii-p9vxv1408y
- CAS:
- 866021-48-9
- Structure:
- Chemical Name:
- Cefmetazole
- CAS:
- 56796-20-4
- MF:
- C15H17N7O5S3
- Structure:
- Chemical Name:
- Cefpirome sulfate
- CAS:
- 98753-19-6
- MF:
- C22H24N6O9S3
- Structure:
- Chemical Name:
- Cefaclor
- CAS:
- 53994-73-3
- MF:
- C15H14ClN3O4S
- Structure:
- Chemical Name:
- Cefoxitin
- CAS:
- 35607-66-0
- MF:
- C16H17N3O7S2
- Structure:
- Chemical Name:
- Ceftiolene
- CAS:
- 77360-52-2
- MF:
- C20H18N8O8S3
- Chemical Name:
- Tilmicosin phosphate
- Structure:
- Chemical Name:
- Cefetamet hydrochloride
- CAS:
- 65052-63-3
- MF:
- C14H15N5O5S2
- Structure:
- Chemical Name:
- Flomoxef
- CAS:
- 99665-00-6
- MF:
- C15H18F2N6O7S2
- Structure:
- Chemical Name:
- Cefetamet pivoxyl
- CAS:
- 65243-33-6
- MF:
- C20H25N5O7S2
- Structure:
- Chemical Name:
- Cefuroxime 1-acetoxyethyl ester
- CAS:
- 64544-07-6
- MF:
- C20H22N4O10S
- Structure:
- Chemical Name:
- SCE 2174
- CAS:
- 95789-30-3
- MF:
- C27H38ClN9O7S3
- Structure:
- Chemical Name:
- Cefotetan
- CAS:
- 69712-56-7
- MF:
- C17H17N7O8S4
- Structure:
- Chemical Name:
- Ceftezole sodium
- CAS:
- 41136-22-5
- MF:
- C13H13N8NaO4S3
- Structure:
- Chemical Name:
- Ceftizoxime
- CAS:
- 68401-81-0
- MF:
- C13H13N5O5S2
- Structure:
- Chemical Name:
- Ceftizoxime alapivoxil
- CAS:
- 135821-54-4
- MF:
- C22H28N6O8S2
- Structure:
- Chemical Name:
- Ceftriaxone sodium
- CAS:
- 74578-69-1
- MF:
- C18H19N8NaO7S3
- Structure:
- Chemical Name:
- sodium (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyimino-acetyl]amino]-3-[(E)-2-(4-methyl-1,3-thiazol-5-yl)ethenyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
- CAS:
- 104146-53-4
- MF:
- C19H19N6NaO5S3
- Structure:
- Chemical Name:
- 3-MERCAPTO-2-METHYL-5-OXO-6-HYDROXY-1,2,4-TRIAZINE
- MF:
- C4H5N3O2S
- Structure:
- Chemical Name:
- Cefradine
- CAS:
- 38821-53-3
- MF:
- C16H19N3O4S
- Structure:
- Chemical Name:
- Cefatrizine
- CAS:
- 51627-14-6
- MF:
- C18H18N6O5S2
- Structure:
- Chemical Name:
- (Z)-2-(5-AMINO-1,2,4-THIADIAZOL-3-YL)-2-METHOXYIMINO ACETIC ACID
- CAS:
- 68786-47-0
- MF:
- C43H33N3O3S
- Structure:
- Chemical Name:
- Ceftazidime
- CAS:
- 78439-06-2
- MF:
- C22H24N6O8S2
- Structure:
- Chemical Name:
- Cefpiramide sodium
- CAS:
- 74849-93-7
- MF:
- C25H25N8NaO7S2
- Structure:
- Chemical Name:
- Cefprozil
- CAS:
- 92665-29-7
- MF:
- C18H19N3O5S
- Structure:
- Chemical Name:
- Cefoperazone
- CAS:
- 62893-19-0
- MF:
- C25H27N9O8S2
- Structure:
- Chemical Name:
- Cephalonium
- CAS:
- 5575-21-3
- MF:
- C20H18N4O5S2
- Structure:
- Chemical Name:
- Cefpodoxime proxetil
- CAS:
- 87239-81-4
- MF:
- C21H27N5O9S2
- Structure:
- Chemical Name:
- Cefpiramide acid
- CAS:
- 70797-11-4
- MF:
- C25H24N8O7S2
- Structure:
- Chemical Name:
- Cefteram pivoxil
- CAS:
- 82547-58-8
- MF:
- C16H17N9O5S2
- Structure:
- Chemical Name:
- Cefoperazone sodium
- CAS:
- 62893-20-3
- MF:
- C25H28N9NaO8S2
- Structure:
- Chemical Name:
- 7-Amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid diphenylmethyl ester
- CAS:
- 36923-21-4
- MF:
- C20H18N2O3S
- Structure:
- Chemical Name:
- Hydroxymethyl-7-Aminocephalosporanic acid
- CAS:
- 15690-38-7
- MF:
- C8H10N2O4S
- Structure:
- Chemical Name:
- CEFATRIZINE PROPYLENE GLYCOL
- CAS:
- 64217-62-5
- MF:
- C21H26N6O7S2
- Structure:
- Chemical Name:
- Cefodizime
- CAS:
- 69739-16-8
- MF:
- C20H20N6O7S4
- Structure:
- Chemical Name:
- Cefotaxime
- CAS:
- 63527-52-6
- MF:
- C16H17N5O7S2
- Structure:
- Chemical Name:
- Cefepime sulfate
- CAS:
- 107648-78-2
- MF:
- C19H25N6O5S2.HO4S
- Structure:
- Chemical Name:
- Cefbuperazone sodium
- CAS:
- 76648-01-6
- MF:
- C22H28N9NaO9S2
- Structure:
- Chemical Name:
- CeftazidiMe
- CAS:
- 72558-82-8
- MF:
- C22H22N6O7S2
- Structure:
- Chemical Name:
- Ceftibuten
- CAS:
- 97519-39-6
- MF:
- C15H14N4O6S2
- Structure:
- Chemical Name:
- LF163892 MONOHYDRATE
- CAS:
- 76470-66-1
- MF:
- C16H16ClN3O4
- Structure:
- Chemical Name:
- Cefotiam
- CAS:
- 61622-34-2
- MF:
- C18H23N9O4S3
- Structure:
- Chemical Name:
- Cefetamet pivoxil hydrochloride
- CAS:
- 111696-23-2
- MF:
- C20H26ClN5O7S2
- Structure:
- Chemical Name:
- Ceftizoxime sodium
- CAS:
- 68401-82-1
- MF:
- C13H14N5NaO5S2
- Structure:
- Chemical Name:
- Latamoxef
- CAS:
- 64952-97-2
- MF:
- C20H20N6O9S
- Structure:
- Chemical Name:
- Cefuroxime
- CAS:
- 55268-75-2
- MF:
- C16H16N4O8S
- Structure:
- Chemical Name:
- Cefmenoxime hydrochloride
- CAS:
- 75738-58-8
- MF:
- C16H18ClN9O5S3
- Structure:
- Chemical Name:
- Cefmenoxime
- CAS:
- 65085-01-0
- MF:
- C16H17N9O5S3
- Structure:
- Chemical Name:
- Cefepime hydrochloride
- CAS:
- 123171-59-5
- MF:
- C19H28Cl2N6O6S2
- Structure:
- Chemical Name:
- 7-AMCA
- CAS:
- 24701-69-7
- MF:
- C9H12N2O4S
- Structure:
- Chemical Name:
- CEFTRIAXONE
- CAS:
- 73384-59-5
- MF:
- C18H18N8O7S3
- Structure:
- Chemical Name:
- CEFMINOX SODIUM
- CAS:
- 92636-39-0
- MF:
- C16H24N7NaO8S3