Cefotiam hydrochloride Chemical Properties

Melting point:

>93°C (dec.)

Boiling point:

94℃

RTECS 

XI0367000

Flash point:

>110°(230°F)

storage temp. 

Inert atmosphere,2-8°C

solubility 

H2O: ≥22M

form 

powder

color 

white to tan

Water Solubility 

Soluble in water

Stability:

Hygroscopic

InChIKey

BWRRTAXZCKVRON-DGPOFWGLSA-N

CAS DataBase Reference

66309-69-1(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36

Safety Statements 

26

WGK Germany 

3

HS Code 

2941906000

Cefotiam hydrochloride Usage And Synthesis

Description

Cefotiam was synthesized by Takeda Chemicals Industries in 1977 as the first cephem derivative to introduce the aminothiazol group in the 7 side chain and the alkylated tetrazole group at the 3 side chain . This drug shows greater antibacterial activity against gram-negative bacteria than the earlier cephalosporins, including Enterobacter, Citrobacter, and indole-positive Proteus, and it retains the same activity as they have against gram-positive organisms. Its excellent activity against Klebsiella and Escherichia coli is based on its ability to penetrate the cell. This is 3- to 70-fold greater than that of cephalothin or cefazolin.

Uses

Cefotiam hydrochloride (SCE-963 hydrochloride) is a parenteral cephalosporin antibiotic. Cefotiam has broad-spectrum activity against Gram-positive and Gram-negative bacteria.

Definition

ChEBI: Cefotiam dihydrochloride is the dihydrochloride salt of cefotiam. It has a role as an antibacterial drug. It contains a cefotiam.

brand name

Ceradon (Takeda).

Pharmacokinetics

Cefotiam Hydrochloride is the hydrochloride salt form of cefotiam, a third-generation, semi-synthetic, beta-lactam cephalosporin antibiotic with antibacterial activity. Cefotiam binds to penicillin-binding proteins (PBPs), transpeptidases that are responsible for crosslinking of peptidoglycan. By preventing crosslinking of peptidoglycan, cell wall integrity is lost and cell wall synthesis is halted.

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