Cefozopran hydrochloride
Cefozopran hydrochloride Basic information
- Product Name:
- Cefozopran hydrochloride
- Synonyms:
-
- Cefozopran hydrochloride
- (6R,7R)-7-[[(2E)-2-(5-Amino-1,2,4-thiadiazol-3-yl)-2-methoxyiminoacetyl]amino]-3-(imidazo[2,3-f]pyridazin-4-ium-1-ylmethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid chloride
- Cefozopran hydrochloride (jp15)
- Czop
- D02233
- Firstcin (tn)
- Cefozopran hydrochlo
- SCE-2787 hydrochloride
- CAS:
- 113981-44-5
- MF:
- C19H18ClN9O5S2
- MW:
- 551.98
- EINECS:
- 1806241-263-5
- Product Categories:
-
- Cefozopran Hydrochloride and its intermediates
- Mol File:
- 113981-44-5.mol
Cefozopran hydrochloride Chemical Properties
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Water Solubility
- Water : ≥ 52 mg/mL (94.20 mM)
Cefozopran hydrochloride Usage And Synthesis
Antimicrobial activity
Cefazolam hydrochloride is suitable for Staphylococcus, Streptococcus, Enterococcus, Peptostreptococcus, Escherichia coli, Enterobacter, Serratia, Klebsiella, Citrobacter, Proteus, Pseudomonas, Influenza Bacillus, Acinetobacter, Bacteroidetes, septicemia caused by sensitive bacteria to cefazolam hydrochloride, trauma infection, respiratory system, urinary system and abdominal cavity, pelvic purulent inflammation, ophthalmology and ENT inflammation, etc.
Biological Activity
Cefozopran (SCE-2787) hydrochloride is a semi-synthetic, parenteral, fourth-generation cephalosporin. As an antibiotic, it has broad-spectrum antibacterial activity and can inhibit most Gram-negative and Gram-positive bacteria.
in vitro
Cefozopran (SCE-2787) is a fourth-generation cephalosporin that has good activity against gram-positive organisms including methicillin-susceptible staphylococci, enterococci, and viridans group streptococci; and against gram-negative organisms including hemophilus influenza. Moreover, cefozopran has comparatively good activity against enterococci and P. aeruginosa , which are refractory to other cephalosporins.
in vivo
Cefozopran (SCE-2787) (5-80 mg/kg; sc; twice a day for 5 days; four-week-old ICR male mice) is effective against acute respiratory tract infections caused by Kiebsiella pneumonia DT-S. In the model of chronic respiratory tract infection caused by K. pneumoniae 27, Cefozopran (20-80 mg/kg; sc; twice a day for 7 days; five-week-old CBA/J female mice) is as effective as Ceftazidime.
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