Cefoselis sulfate
Cefoselis sulfate Basic information
- Product Name:
- Cefoselis sulfate
- Synonyms:
-
- CEFOSELIS SULFATE
- FK 037
- 7-[[2-(2-amino-4-thiazolyl)-2-methoxyimino-1-oxoethyl]amino]-3-[[2-(2-hydroxyethyl)-3-imino-1-pyrazolyl]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
- (6R-(6alpha,7beta(Z)))-7-(((2-Amino-4-thiazolyl)(methoxyimino)acetyl)amino)-3-((2,3-dihydro-2-(2-hydroxyethyl)-3-imino-1H-pyrazol-1-yl)methyl)-8-oxo-5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid sulfate
- Winsef
- (6R,7R,E)-7-(2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)-3-((2-(2-hydroxyethyl)-3-imino-2,3-dihydropyrazol-1-yl)methyl)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid, sulfate
- FK 037 Sulfate
- Cefoselis sulfate USP/EP/BP
- CAS:
- 122841-12-7
- MF:
- C19H24N8O10S3
- MW:
- 620.63
- EINECS:
- 1533716-785-6
- Product Categories:
-
- Inhibitors
- Cefoselis sulfate and its intermediates
- Mol File:
- 122841-12-7.mol
Cefoselis sulfate Chemical Properties
- storage temp.
- 4°C, protect from light, stored under nitrogen
- solubility
- DMSO : 100 mg/mL (161.12 mM; Need ultrasonic)H2O : 14.29 mg/mL (23.02 mM; Need ultrasonic)
- form
- Powder
- CAS DataBase Reference
- 122841-12-7(CAS DataBase Reference)
Cefoselis sulfate Usage And Synthesis
Description
Cefoselis is a new fourth-generation cephalosporin and was launched
in Japan as a parenteral antibiotic for a variety of infections including
Staphylococcus aureus (particularly the methicillin-resistant MRSA) and
Pseudornonas aeruginosa. It can be prepared in 3 related ways, all using 2-
pyrazolomethyl-3-cephem-4-carboxylic as the key intermediate. In preclinical
studies, Cefolesis had better MIC50s than Ceftazidime against Streptococcus
pneurnoniae or Staphflococcus aureus (methicillin-sensitive MSSA or resistant
MRSA) and showed significant antibacterial activity against Citrobacter and
Enterobacter.
Cefolesis is well tolerated in clinical studies, being eliminated mainly via
glomerular filtration in humans.
Originator
Fujisawa (Japan)
Uses
antibiotic
Definition
ChEBI: Cefoselis sulfate is an azaheterocycle sulfate salt. It is functionally related to a member of cefoselis.
brand name
Wincef
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