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Cefetamet hydrochloride

Basic information Safety Supplier Related

Cefetamet hydrochloride Basic information

Product Name:
Cefetamet hydrochloride
Synonyms:
  • (6R,7R)-7-[[(Z)-(2-Aminothiazole-4-yl)(methoxyimino)acetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]octa-2-ene-2-carboxylic acid
  • FR-13300
  • LY-97964
  • Cefyl
  • Globocef
  • LY-097964
  • Ro.15-8074:Ro-15-8075
  • 7-[[2-(2-amino-4-thiazolyl)-2-methoxyimino-1-oxoethyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid hydrochloride
CAS:
65052-63-3
MF:
C14H15N5O5S2
MW:
397.43
EINECS:
675-838-9
Mol File:
65052-63-3.mol
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Cefetamet hydrochloride Chemical Properties

Density 
1.83±0.1 g/cm3(Predicted)
pka
3.11±0.50(Predicted)
CAS DataBase Reference
65052-63-3(CAS DataBase Reference)
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Safety Information

HS Code 
2941906000
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Cefetamet hydrochloride Usage And Synthesis

Uses

Cefetamet is a third-generation cephalosporin antibiotic and the active agent of Cefeamet pivoxil (C242780) after hydrolysis.

Antimicrobial activity

A semisynthetic cephalosporin formulated for oral use as the prodrug ester, cefetamet pivoxyl. It is less active than cefaclor and cefadroxil against Staph. aureus, but as active against streptococci and more active against enterobacteria, H. influenzae and N. gonorrhoeae, including β-lactamase-producing strains. L. monocytogenes, C. difficile, Sten. maltophilia and Burk. cepacia are all resistant. It is resistant to hydrolysis by common plasmid-mediated enzymes.
The absolute bioavailability is about 50%. The plasma peak is delayed by food. Binding to plasma protein is about 20%. The volume of distribution approximates to the extracellular water. It is excreted into urine with a half-life of 2–2.5 h, principally in the glomerular filtrate. Elimination is linearly related to creatinine clearance. Side effects and uses are similar to those of other group 5 cephalosporins.

Cefetamet hydrochloride Preparation Products And Raw materials

Raw materials

Cefetamet hydrochlorideSupplier

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