Tilmicosin Chemical Properties

Melting point:

>97°C (dec.)

alpha 

D23 +12.75° (c = 0.010004 in CHCl3, 5 cm)

Boiling point:

926.6±65.0 °C(Predicted)

Density 

1.18±0.1 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Store in freezer, under -20°C

solubility 

Acetone (Slightly), DMSO (Slightly), Methanol (Sparingly)

pka

pKa (66% DMF): 7.4, 8.5(at 25℃)

color 

White to Off-White

InChIKey

JTSDBFGMPLKDCD-XVFHVFLVSA-N

EPA Substance Registry System

Tilmicosin (108050-54-0)

Safety Information

WGK Germany 

3

HS Code 

29419090

Hazardous Substances Data

108050-54-0(Hazardous Substances Data)

Tilmicosin Usage And Synthesis

Brief introduction

Tilmicosin is a relatively novel semi-synthetic macrolide antibiotics derived from tylosin for being applied to livestock and poultry. The chemical name is 4A-O-de (2, 6-dideoxy-methyl-3-C--L-ribose-pyran-hexyl)-20-deoxy-20-(3,5-dimethyl-1-piperidinyl)-[20 (cis: trans)] tylosin. Molecule formula is C46H80N2O13 and the molecular weight of 869.15.
Tilmicosin has a similar antibacterial spectrum as tylosin but has enhanced effect on the anti-Pasteurella multocida and hemolytic pasteurella. It was successfully developed in 1980s and initially used with a code of EL-870. Common trade names include Pulmotil © Micotil ©, preparations include tilmicosin soluble powder, premix (20%) preparation, and injection. In 1990 it was approved in most European countries; it was approved in the US in 1992, and included in USP. China also has some domestic enterprises approved for production of tilmicosin.
Because of its special antibacterial activity and pharmacokinetic characteristics, the drug has been approved for clinical prevention and treatment of infectious diseases for cattle, goats, sheep, cows, pigs, and chickens. It is especially applied to the treatment of respiratory diseases of livestock, such as cattle Actinobacillus pleuropneumonia, Pasteurella disease, chicken mycoplasmosis and mastitis of lactating animals.
The above information is edited by the Chemicalbook of Dai Xiongfeng.

Chemical Properties

It is white or white powder with humidity: ≤5.0%.

Uses

It can be used as anti-bacterial.
It is mainly used for the treatment of infection caused by pleuropneumonia, Actinobacillus, Pasteurella and mycoplasma.

Chemical Properties

White Solid

Uses

Tilmicosin is a semi-synthetic antibiotic derived from desmycosin (tylosin B), a minor co-metabolite of tylosin. Tilmicosin is produced by reductive amination of desmycosin. Desmycosin itself is prepared by the partial hydrolysis of tylosin with the loss of the mycarosyl sugar. The piperidinyl group at C20 of tilmicosin provides a wider spectrum of antibiotic action, in particular good protection against Pasteurella in livestock.

Uses

A Macrolide antibiotic.

Uses

Macrolide antibiotic structurally related to tylosin. Antibacterial

Veterinary Drugs and Treatments

Tilmicosin is indicated for the treatment of bovine or ovine respiratory diseases (BRD) caused by Mannheimia (Pasturella) haemolytica.

Tilmicosin(108050-54-0)Related Product Information

• TILMICOSIN PHOSPHATE
• Dacthal
• Dimethyl ether
• Dimethyl carbonate
• ETHANE
• N,N-Dimethylformamide
• Dimethyl disulfide
• Dimethyl fumarate
• Dimethyl sulfoxide
• Dimethyl sulfate
• Dimethyl phthalate
• Tilorone dihydrochloride
• Tilmicosin phosphate
• 8,10-DODECADIEN-1-OL
• Tilmicosin (FDA)
• Tylosin
• ISO-PROPYL-UNDECYLENATE
• (R)-3-METHYL-4-TETRAHYDROPYRANYLOXYBUTYLAMINE