Artemisinin-d3 Chemical Properties

Melting point:

156-157°C

storage temp. 

-20°C Freezer

solubility 

DMSO: Slightly soluble,Methanol: Slightly soluble

form 

A solid

CAS DataBase Reference

176652-07-6

Artemisinin-d3 Usage And Synthesis

Description

Artemisinin-d₃ is intended for use as an internal standard for the quantification of artemisinin . Artemisinin is an endoperoxide antimalarial agent with anticancer activity. It reduces the growth of various P. falciparum strains in vitro (IC₅₀s = 3.98-20.36 nM) and reduces parasitemia in mice infected with P. falciparum with a curative dose (CD₅₀) value of 140 mg/kg. It also reduces P. berghei infection in mice (ED₅₀ = 5.6 mg/kg per day). Artemisinin (100-400 μM) induces cell cycle arrest in the G₀/G₁ phase and apoptosis and inhibits growth of SK-N-AS, BE(2)-C, SK-N-DZ, and SHEP1 neuroblastoma cells in a time- and concentration-dependent manner. It also suppresses BE(2)-C cell colony formation in a soft agar assay and reduces tumor growth in a BE(2)-C mouse xenograft model. Formulations containing artemisinin have been used in combination therapies for the treatment of malaria.

Chemical Properties

Crystalline Solid

Uses

Active antimalarial constituent of the tradional Chinese medicinal herb Artemisia annua L., Compositae, which has been known for almost 2000 years as Qinghao. Antimalarial

IC 50

Plasmodium

References

[1] MONIQUE AKOACHERE. In vitro assessment of methylene blue on chloroquine-sensitive and -resistant Plasmodium falciparum strains reveals synergistic action with artemisinins.[J]. Antimicrobial Agents and Chemotherapy, 2005: 4592-4597. DOI: 10.1128/aac.49.11.4592-4597.2005
[2] SHUNQIN ZHU. Artemisinin reduces cell proliferation and induces apoptosis in neuroblastoma.[J]. Oncology reports, 2014, 32 3: 1094-1100. DOI: 10.3892/or.2014.3323
[3] ANNE ROBERT. The antimalarial drug artemisinin alkylates heme in infected mice.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2005, 102 38: 13676-13680. DOI: 10.1073/pnas.0500972102
[4] A.N. CHAWIRA. The effect of combinations of qinghaosu (artemisinin) with standard antimalarial drugs in the suppressive treatment of malaria in mice[J]. Transactions of The Royal Society of Tropical Medicine and Hygiene, 1987, 81 4: Pages 554-558. DOI: 10.1016/0035-9203(87)90404-4

Artemisinin-d3(176652-07-6)Related Product Information

• Artemisinin
• [[p-(2-methoxyethyl)phenoxy]methyl]oxirane
• 9-epi-ArteMisinin
• (3R,5aS,6R,8aS,9R,12R,12aR)-Decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-ol
• (11S)-Dihydroartemisinic Acid
• Dihydro ArteMisinin-13C,d4
• Deoxy Artemisinin
• (3aS,4R,6aS,7R,10R,10aR)-Octahydro-4,7-diMethyl-2H,10H-furo[3,2-i][2]benzopyran-8,10-diol 10-Acetate
• DHQHS 2
• Diketo aldehyde iMpurity of dihydroarteMisinin
• (11S)-Dihydroartemisinic Aldehyde
• artemisic acid
• anhydrodihydroartemisinin
• DihydroarteMisinic acid
• (11S)-Dihydroartemisinic Alcohol
• Artemisinin Impurity 6
• Artemisinic Acid Carbonate Impurity
• Atemisinic Aldehyde Impurity