Basic information Safety Supplier Related

DHEA-S

Basic information Safety Supplier Related

DHEA-S Basic information

Product Name:
DHEA-S
Synonyms:
  • 10,13-dimethyl-17-oxo-3-sulfooxy-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthrene
  • Formylisoglutamic acid
  • Dehydroepiandrosterone Sulfate
  • DEHYDROEPIANDROSTERONESULPHATE
  • [(3S,8R,9S,10R,13S,14S)-10,13-dimethyl-17-oxo-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-yl] hydrogen sulfate
  • sulfuric acid [(3S,8R,9S,10R,13S,14S)-17-keto-10,13-dimethyl-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-yl] ester
  • (3β)-3-(Sulfooxy)androst-5-en-17-one
  • Prasterone Sulfate Sports Nutrition Supplements Prasterone Sodium Sulfate 651-48-9
CAS:
651-48-9
MF:
C19H28O5S
MW:
368.49
Mol File:
651-48-9.mol
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DHEA-S Chemical Properties

Boiling point:
468.81°C (rough estimate)
Density 
1.1763 (rough estimate)
refractive index 
1.5300 (estimate)
Melting point:
190-192 °C
pka
-3.51±0.18(Predicted)
form 
Solid
color 
White to off-white
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DHEA-S Usage And Synthesis

Uses

Dehydroepiandrosterone sulfate, a neuroactive neurosteroid, plays a major role in brain development and aging by influencing the migration of neurons, arborization of dendrites, and formation of new synapses[1][2][3].

Definition

ChEBI: A steroid sulfate that is the 3-sulfooxy derivative of dehydroepiandrosterone.

in vivo

DHEAS chronic administration produces a dose-dependent effect on performance[3].

Animal Model:Sixty-four male Sprague-Dawley rats, approximately 90 days of age (300-400 g)[3].
Dosage:5, 10, or 20 mg/kg.
Administration:Subcutaneous injection starting 7 days post-surgery and 1 h prior to all behavioral testing.
Result:Significantly effective in improving latency to reach the platform as compared to injured rats receiving vehicle.

IC 50

Human Endogenous Metabolite

References

[1] E E Baulieu, et al. Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) as neuroactive neurosteroids. Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4089-91. DOI:10.1073/pnas.95.8.4089
[2] C R Parker Jr, et al. Dehydroepiandrosterone and dehydroepiandrosterone sulfate production in the human adrenal during development and aging. Steroids. 1999 Sep;64(9):640-7. DOI:10.1016/s0039-128x(99)00046-x
[3] Stuart W Hoffman, et al. The delayed administration of dehydroepiandrosterone sulfate improves recovery of function after traumatic brain injury in rats. J Neurotrauma. 2003 Sep;20(9):859-70. DOI:10.1089/089771503322385791

DHEA-SSupplier

Sichuan Wei Keqi Biological Technology Co., Ltd.
Tel
028-81700200 18116577057
Email
3003855609@qq.com
Hangzhou J&H Chemical Co., Ltd.
Tel
0571-87396432
Email
sales@jhechem.com
Codow Chemical Co.,Ltd.
Tel
18620099427
Email
amy@howeipharm.com
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Email
3008007409@qq.com
Shandong JunRui Pharmaceutical Co., Ltd.
Tel
0539-5636807 15318528770
Email
ffeng813@163.com
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DHEA-S(651-48-9)Related Product Information