6-ANILINO-5,8-QUINOLINEDIONE Chemical Properties

Melting point:

184-185°C

Boiling point:

446.9±45.0 °C(Predicted)

Density 

1.400±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

0.1 M HCl: 1 mg/mL

form 

solid

pka

-0.63±0.20(Predicted)

color 

violet

CAS DataBase Reference

91300-60-6(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

40-36/37/38

Safety Statements 

36/37-36-26

WGK Germany 

2

HS Code 

2933499090

6-ANILINO-5,8-QUINOLINEDIONE Usage And Synthesis

Chemical Properties

Red-Brown Solid

Uses

Inhibits nitric-oxide-induced activation of soluble guanylate cyclase (IC50=2) in a dose-dependent and reversible manner. It blocks acetylcholine induced vasorelaxation. Also an inhibitor of antigen-induced leukotriene release

Uses

Inhibits nitric-oxide-induced activation of soluble guanylate cyclase (IC50=2μM) in a dose-dependent and reversible manner. It blocks acetylcholine induced vasorelaxation. Also an inhibitor of antigen-induced leukotriene release.

Uses

LY83583 is an inhibitor of soluble guanylate cyclase and of cGMP production. It inhibits soluble guanylate cyclase in human platelets with an IC50 value of 2 μM. LY83583 also inhibits leukotriene synthesis in guinea pig lung and rat peritoneal cells with an IC50 value of 1.8 μM and is a noncompetitive inhibitor of glutathione reductase in bovine intestinal mucosa with a Ki value of 3 μM.[Cayman Chemical]

Definition

ChEBI: A quinolone that is quinoline-5,8-dione in which the hydrogen at position 6 is replaced by an anilino group.

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