inophyllum B
inophyllum B Basic information
- Product Name:
- inophyllum B
- Synonyms:
-
- inophyllum B
- 2H,6H,10H-Benzo[1,2-b:3,4-b':5,6-b'']tripyran-2-one, 11,12-dihydro-12-hydroxy-6,6,10,11-tetramethyl-4-phenyl-, (10R,11S,12S)-
- CAS:
- 41135-06-2
- MF:
- C25H24O5
- MW:
- 404.46
- Mol File:
- 41135-06-2.mol
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inophyllum B Chemical Properties
- Melting point:
- 58-62 °C
- Boiling point:
- 564.7±50.0 °C(Predicted)
- Density
- 1.249±0.06 g/cm3(Predicted)
- pka
- 13.37±0.70(Predicted)
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inophyllum B Usage And Synthesis
Uses
Inophyllum B ((+)-Inophyllum B) is a potent HIV Reverse Transcriptase inhibitor with an IC50 value of 38 nM. Inophyllum B inhibits HIV-1 (IC50=1.4 μM) in vitro cell culture. Inophyllum B can be isolated from the acetone extract of the giant African snail, Achatina fulica[1].
IC 50
HIV-1: 1.4 μM (IC50); Reverse Transcriptase: 38 nM (IC50)
References
[1] Patil AD, et al. The inophyllums, novel inhibitors of HIV-1 reverse transcriptase isolated from the Malaysian tree, Calophyllum inophyllum Linn. J Med Chem. 1993 Dec 24;36(26):4131-8. DOI:10.1021/jm00078a001
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inophyllum B(41135-06-2)Related Product Information
- 2,4,6-TRIMETHOXYBENZYL ALCOHOL
- CIS-2-METHOXYCINNAMIC ACID
- Dimecrotic acid
- 5,7-Dihydroxy-4-methylcoumarin
- 1,3-DIVINYLBENZENE
- 7-HYDROXY-4-PHENYLCOUMARIN 97
- 1,3-Bis(1-methylethoxy)-benzene
- 2-(Allyloxy)benzyl alcohol
- 2 6-DIETHOXYBENZYL ALCOHOL 97
- (4-TERT-BUTOXY-PHENYL)-METHANOL
- 5 7-DIHYDROXY-4-PHENYLCOUMARIN
- 2H-1-BENZOPYRAN-4-OL, 3,4-DIHYDRO-7-METHOXY-
- 7-METHOXY-2,2-DIMETHYL-3-CHROMENE
- 2,4-Dimethoxy-3-methylbenzyl alcohol
- 4-Methyl-5,7-dimethoxycoumarin
- 2,4,6-TRIMETHOXYDIPHENYLMETHANE
- inophyllum B