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Ethyl potassium malonate

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Ethyl potassium malonate Basic information

Product Name:
Ethyl potassium malonate
Synonyms:
  • AKOS 310
  • MALONIC ACID MONOETHYL ESTER POTASSIUM SALT
  • ETHYL POTASSIUM MALONATE
  • ETHYL MALONATE MONOPOTASSIUM SALT
  • ETHYL MALONATE POTASSIUM SALT
  • ETHYL MONO POTASSIUM MALONATE
  • KEM
  • MALONIC ACID MONOETHYL ESTER POTASSIUM
CAS:
6148-64-7
MF:
C5H9KO4
MW:
172.22
EINECS:
228-156-7
Product Categories:
  • Pharmaceutical Intermediates
  • bc0001
  • 6148-64-7
Mol File:
6148-64-7.mol
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Ethyl potassium malonate Chemical Properties

Melting point:
194 °C (dec.) (lit.)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Methanol (Slightly), Water (Slightly)
form 
Powder or Cyrstals
color 
White
PH
pH(50g/l, 25℃) : 5.5~8.0
Water Solubility 
soluble
Sensitive 
Hygroscopic
BRN 
3721682
InChIKey
WVUCPRGADMCTBN-UHFFFAOYSA-M
CAS DataBase Reference
6148-64-7(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-37/39
WGK Germany 
2
HS Code 
29171910

MSDS

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Ethyl potassium malonate Usage And Synthesis

Chemical Properties

white crystals or powder

Uses

Ethyl potassium malonate is used as a competitive inhibitor of the enzyme succinate dehydrogenase. It acts as a precursor to produce (trimethylsilyl)ethyl malonate, which is utilized to prepare beta-ketoesters by acylation. Further, it reacts with aryl nitriles to prepare beta-amino acrylates in the presence of zinc chloride and a catalytic amount of Hünig's base. In addition to this, it serves as an intermediate for the preparation of ethyl tert-butyl malonate.

Uses

Ethyl potassium malonate (potassium ethyl malonate) may be used to generate (trimethylsilyl)ethyl malonate in situ, which can be acylated to prepare a variety of β-ketoesters or alkylidene malonates.

General Description

Ethyl potassium malonate (potassium ethyl malonate) reacts with aryl nitriles in the presence of zinc chloride and a catalytic amount of Hünig′s base to yield β-amino acrylates. Ethyl potassium malonate is formed as an intermediate during the synthesis of ethyl tert-butyl malonate.

Ethyl potassium malonate Preparation Products And Raw materials

Preparation Products

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