7-Methoxy-6-benzyloxyquinazolin-4-one Chemical Properties

Melting point:

252 °C(Solv: methanol (67-56-1))

Boiling point:

475.4±55.0 °C(Predicted)

Density 

1.26

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

pka

1.43±0.20(Predicted)

Appearance

Off-white to gray Solid

7-Methoxy-6-benzyloxyquinazolin-4-one Usage And Synthesis

Synthesis

Synthesis of 6-(benzyloxy)-7-methoxyquinazolin-4(3H)-one: 2-amino-5-(benzyloxy)-4-methoxybenzoic acid (5 g, 18.3 mmol) was mixed with formamidine acetate (3.8 g, 36.6 mmol) in ethylene glycol monomethyl ether (25 mL). The reaction mixture was heated at 130°C for 24 hours. After completion of the reaction, it was cooled to room temperature and concentrated in vacuum to remove some of the solvent. Subsequently, ammonium hydroxide (5 mL, 30% aqueous solution) and water (50 mL) were added. The precipitated solid was collected by filtration, washed with water and hexane, and dried under vacuum to give 4.87 g of 6-benzyloxy-7-methoxyquinazolin-4-one in 94% yield. Mass spectrum (AP/CI): 283.1 (M+H)+.

References

[1] Patent: WO2008/20302, 2008, A2. Location in patent: Page/Page column 29
[2] Journal of Medicinal Chemistry, 2011, vol. 54, # 13, p. 4536 - 4547

7-Methoxy-6-benzyloxyquinazolin-4-one(286371-64-0)Related Product Information

• 4-Hydroxyquinazoline
• m-Anisyl alcohol
• (Trifluoromethoxy)benzene
• 2-Methoxyethanol
• p-Anisidine
• Methoxyacetic acid
• p-Anisaldehyde
• 4-Methoxybenzylchloride
• Methoxydiethylborane
• POLY(ETHYLENE GLYCOL) METHYL ETHER ACRYLATE
• Anisole
• Methoxy
• 7-Methoxy-6-benzyloxyquinazolin-4-one