AC-YVAD-CMK
AC-YVAD-CMK Basic information
- Product Name:
- AC-YVAD-CMK
- Synonyms:
-
- ICE INHIBITOR II
- IL-1BETA CONVERTING ENZYME (ICE) INHIBITOR II
- IL-1BETA CONVERTING ENZYME INHIBITOR II
- INTERLEUKIN-1BETA (IL-1BETA) CONVERTING ENZYME (ICE) INHIBITOR II
- CASPASE-1 INHIBITOR (CHLOROMETHYLKETONE)
- CASPASE-1 INHIBITOR II
- AC-TYR-ALA-ASP-CHLOROMETHYLKETONE
- AC-TYR-VAL-ALA-ASP-CH2CL
- CAS:
- 178603-78-6
- MF:
- C24H33ClN4O8
- MW:
- 540.99
- Product Categories:
-
- Caspase/Related Products
- peptide
- Pepetides
- peptides
- Elisa Kit-Mouse Elisa Kit
- Mol File:
- 178603-78-6.mol
AC-YVAD-CMK Chemical Properties
- Melting point:
- >205°C (dec.)
- RTECS
- AY3079566
- storage temp.
- -20°C
- solubility
- DMSO (Slightly, Sonicated), Methanol (Slightly, Heated, Sonicated)
- form
- White solid
- color
- white to off-white
- Stability:
- Hygroscopic
MSDS
- Language:English Provider:SigmaAldrich
AC-YVAD-CMK Usage And Synthesis
Uses
Ac-YVAD-CMK is a selective, irreversible inhibitor of interleukin-1β converting enzyme (ICE; Caspase-1). Ac-YVAD-CMK is neuroprotective in a rat model of cerebral ischemia.[Cayman Chemical]
Uses
Ac-YVAD-cmk has been used:
- as an inflammasome inhibitor to add to THP-1 cells or PBMC (peripheral blood mononuclear cell) before stimulation
- as a caspase-1 inhibitor injected to C57BL/6 mice
- as a caspase-1 inhibitor, administered into mice before and during hematopoietic stem cell transplantation (HSCT) to evaluate its effect on bone marrow inflammatory injury
- to abolish the histidine-rich protein II (HRPII) effect on transendothelial electrical resistance (TEER)
- as caspase 1 inhibitor, to treat MCF-7 tumor xenograft mice, to validate the role of inflammasomes activation in tumor growth?in vivo?condition
General Description
Interleukin-1β converting enzyme (ICE) is a cysteine protease that cleaves the IL-1β precursor to mature IL-1β. Caspase-1 inhibitor II is a cell-permeable, irreversible inhibitor of Caspase-1, Caspase-4, and Caspase-5. Inhibits CPP32/Apopain at a much higher concentration. Inhibits Fas-mediated apoptosis and acidic sphingomyelinase activation.
Biochem/physiol Actions
Ac-YVAD-cmk is a selective ireversible inhibitor of caspase-1 (interleukin-1β converting enzyme, ICE) with some activity also against caspase-4. Ac-YVAD-cmk is anti-apoptotic and has anti-inflammatory and neuroprotective effects, thought to result from its preventing caspase-1 activation of the proinflammatory cytokine, Interleukin-1β.
AC-YVAD-CMKSupplier
- Tel
- 18818260767
- sales@chemegen.com
- Tel
- 0571-85350119 15888826472
- bptsales@163.com
- Tel
- 821-50328103-801 18930552037
- 3bsc@sina.com
- Tel
- 21-61263452 13641803416
- ymbetter@glbiochem.com
- Tel
- 0330-2528181
- sales@vdmbio.com