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AC-YVAD-CHO

Basic information Safety Supplier Related

AC-YVAD-CHO Basic information

Product Name:
AC-YVAD-CHO
Synonyms:
  • N-ACETYL-L-TYROSYL-L-VALYL-N-[(1S)-2-CARBOXYL-1-FORMYLETHYL]-L-ALANINAMIDE
  • N-ACETYL-TYR-VAL-ALA-ASP-CHO (ALDEHYDE)
  • N-ACETYL-TYR-VAL-ALA-GLU-AL
  • N-AC-TYR-VAL-ALA-ASP-CHO
  • N-ACETYL-ALA-ALA-VAL-ALA-LEU-LEU-PRO-ALA-VAL-LEU-LEU-ALA-LEU-LEU-ALA-PRO-TYR-VAL-ALA-ASP-CHO (ALDEHYDE)
  • TYR-VAL-ALA-ASP-CHO
  • YVAD-CHO
  • ICE INHIBITOR
CAS:
143313-51-3
MF:
C23H32N4O8
MW:
492.52
Product Categories:
  • Caspases/Apoptosis
  • peptide
  • Pepetides
  • peptides
Mol File:
143313-51-3.mol
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AC-YVAD-CHO Chemical Properties

Boiling point:
937.7±65.0 °C(Predicted)
Density 
1.276±0.06 g/cm3(Predicted)
storage temp. 
−20°C
solubility 
DMF:30.0(Max Conc. mg/mL);60.91(Max Conc. mM)
DMSO:30.0(Max Conc. mg/mL);60.91(Max Conc. mM)
Ethanol:30.0(Max Conc. mg/mL);60.91(Max Conc. mM)
PBS (pH 7.2):5.0(Max Conc. mg/mL);10.15(Max Conc. mM)
pka
4.20±0.10(Predicted)
form 
Powder
color 
White to off-white
Sensitive 
Moisture Sensitive
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Safety Information

WGK Germany 
3

MSDS

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AC-YVAD-CHO Usage And Synthesis

Description

Ac-YVAD-CHO is an inhibitor of caspase-1/interleukin-1β converting enzyme (ICE; Ki = 0.76 nM) and an acetylated form of the caspase-1 inhibitor YVAD-CHO . It is selective for caspase-1 over caspase-4, -5, -8, -9, and -10 (Kis = 163-970 nM), as well as over caspase-2, -3, -6, and -7 (Kis = >10,000 nM for all). It inhibits activation of caspase-1 and IL-1β in a cell-free assay using LPS-treated THP-1 cell homogenates when used at a concentration of 5 μM. Ac-YVAD-CHO (12.5 μmol/kg) reduces pancreatic levels of IL-18 and serum levels of IL-1β, as well as reduces pyroptosis of pancreatic cells, in a mouse model of cerulein-induced acute pancreatitis but does not decrease pancreatic expression of NOD-like receptor protein 3 (NLRP3). It increases susceptibility to lethal E. coli infection but prevents LPS-induced death in C3H/HeN mice when administered at doses of 5 and 10 mg/kg, respectively.

Uses

A potent, specific, and reversible inhibitor of caspases-1, -4 and -5

AC-YVAD-CHOSupplier

GL Biochem (Shanghai) Ltd
Tel
21-61263452 13641803416
Email
ymbetter@glbiochem.com
Shanghai Hanhong Scientific Co.,Ltd.
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021-54306202 13764082696
Email
info@hanhongsci.com
Chemsky (shanghai) International Co.,Ltd
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021-50135380
Email
shchemsky@sina.com
Alabiotech Inc.
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001-619-354-5251
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sales@alabiotech-e.com
Shanghai Chaolan Chemical Technology Center
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021-QQ:65489617 15618227136
Email
Sales@ATKchemical.com