AC-YVAD-CHO
AC-YVAD-CHO Basic information
- Product Name:
- AC-YVAD-CHO
- Synonyms:
-
- N-ACETYL-L-TYROSYL-L-VALYL-N-[(1S)-2-CARBOXYL-1-FORMYLETHYL]-L-ALANINAMIDE
- N-ACETYL-TYR-VAL-ALA-ASP-CHO (ALDEHYDE)
- N-ACETYL-TYR-VAL-ALA-GLU-AL
- N-AC-TYR-VAL-ALA-ASP-CHO
- N-ACETYL-ALA-ALA-VAL-ALA-LEU-LEU-PRO-ALA-VAL-LEU-LEU-ALA-LEU-LEU-ALA-PRO-TYR-VAL-ALA-ASP-CHO (ALDEHYDE)
- TYR-VAL-ALA-ASP-CHO
- YVAD-CHO
- ICE INHIBITOR
- CAS:
- 143313-51-3
- MF:
- C23H32N4O8
- MW:
- 492.52
- Product Categories:
-
- Caspases/Apoptosis
- peptide
- Pepetides
- peptides
- Mol File:
- 143313-51-3.mol
AC-YVAD-CHO Chemical Properties
- Boiling point:
- 937.7±65.0 °C(Predicted)
- Density
- 1.276±0.06 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- DMF:30.0(Max Conc. mg/mL);60.91(Max Conc. mM)
DMSO:30.0(Max Conc. mg/mL);60.91(Max Conc. mM)
Ethanol:30.0(Max Conc. mg/mL);60.91(Max Conc. mM)
PBS (pH 7.2):5.0(Max Conc. mg/mL);10.15(Max Conc. mM) - pka
- 4.20±0.10(Predicted)
- form
- Powder
- Sensitive
- Moisture Sensitive
MSDS
- Language:English Provider:SigmaAldrich
AC-YVAD-CHO Usage And Synthesis
Description
Ac-YVAD-CHO is an inhibitor of caspase-1/interleukin-1β converting enzyme (ICE; Ki = 0.76 nM) and an acetylated form of the caspase-1 inhibitor YVAD-CHO . It is selective for caspase-1 over caspase-4, -5, -8, -9, and -10 (Kis = 163-970 nM), as well as over caspase-2, -3, -6, and -7 (Kis = >10,000 nM for all). It inhibits activation of caspase-1 and IL-1β in a cell-free assay using LPS-treated THP-1 cell homogenates when used at a concentration of 5 μM. Ac-YVAD-CHO (12.5 μmol/kg) reduces pancreatic levels of IL-18 and serum levels of IL-1β, as well as reduces pyroptosis of pancreatic cells, in a mouse model of cerulein-induced acute pancreatitis but does not decrease pancreatic expression of NOD-like receptor protein 3 (NLRP3). It increases susceptibility to lethal E. coli infection but prevents LPS-induced death in C3H/HeN mice when administered at doses of 5 and 10 mg/kg, respectively.
Uses
A potent, specific, and reversible inhibitor of caspases-1, -4 and -5
AC-YVAD-CHOSupplier
- Tel
- 21-61263452 13641803416
- ymbetter@glbiochem.com
- Tel
- 021-54306202 13764082696;
- info@hanhongsci.com
- Tel
- 021-50135380
- shchemsky@sina.com
- Tel
- 001-619-354-5251
- sales@alabiotech-e.com
- Tel
- QQ:65489617 15618227136
- info@SuperLan-chem.com
AC-YVAD-CHO(143313-51-3)Related Product Information
- AC-LYS(AC)-D-ALA-D-ALA-OH
- AC-WEHD-AMC
- AC-ESMD-CHO
- AC-WEHD-CHO
- ICE INHIBITOR IV
- N-acetyl-N-methyl-L-tyrosyl-L-valyl-N-[(1S)-2-carboxy-1-formylethyl]-L-Alaninamide
- AC-TYR-VAL-LYS(BIOTINYL)-ASP-2,6-DIMETHYLBENZOYLOXYMETHYLKETONE
- ASN-GLU-ALA-TYR-VAL-HIS-ASP-ALA-PRO-VAL-ARG-SER-LEU-ASN
- AC-YVAD-AFC
- DABCYL-TYR-VAL-ALA-ASP-ALA-PRO-VAL-EDANS
- AC-YVAD-CMK
- AC-TYR-(NME)VAL-ALA-(NME)ASP-CHO
- MCA-TYR-VAL-ALA-ASP-ALA-PRO-LYS(DNP)-OH
- AC-YVAD-PNA
- N-ACETYL-TYR-VAL-LYS-ASP-AL
- AC-YVAD-AMC
- ICE INHIBITOR II, BIOTINYLATED,IL-1BETA CONVERTING ENZYME (ICE) INHIBITOR II, BIOTINYLATED
- BIOTIN-TYR-VAL-ALA-ASP-CHO