2',4',5'-TRIMETHOXYACETOPHENONE Chemical Properties

Melting point:

98-102°C

Boiling point:

285-290 °C(Press: 33 Torr)

Density 

1.089±0.06 g/cm3(Predicted)

EPA Substance Registry System

Ethanone, 1-(2,4,5-trimethoxyphenyl)- (1818-28-6)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36

Safety Statements 

26

WGK Germany 

3

2',4',5'-TRIMETHOXYACETOPHENONE Usage And Synthesis

Preparation

Preparation by reaction of acetyl chloride with hydroxyhydroquinone trimethyl ether in the presence of aluminium chloride.

Synthesis Reference(s)

Journal of Medicinal Chemistry, 33, p. 1155, 1990 DOI: 10.1021/jm00166a012

Synthesis

2,4,5-Trimethoxy acetophenone is synthesised using 2-Hydroxy-4,5-dimethoxy acetophenone as raw material by chemical reaction. The specific synthesis steps are as follows:
2-Hydroxy-4,5-dimethoxyacetophenone(5 g,0.0255 mole) in dry acetone (100 ml)is refluxed for 30 hr under anhydrous conditions with dimethyl sulphate (2.8 ml,3.78 g,0.03 mole)and ignited potassium carbonate (20 g).The mixture is filtered and the inorganic residue washed with hot acetone (2 x 20 ml).The combined acetone solution is distilled and the oily residue macerated with crushed ice.The solid product is filtered,washed with water and dried.It is crystallised from benzene as colourless needles.Yield 4.5g (84.1%).M.p.97(lit.m.p.102).

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