B-SITOSTENONE Chemical Properties

Melting point:

82 °C(Solv: methanol (67-56-1))

Boiling point:

503.8±17.0 °C(Predicted)

Density 

0.97±0.1 g/cm3(Predicted)

solubility 

DMF: 0.33 mg/ml
Ethanol: Slightly soluble

form 

Solid

color 

White to off-white

LogP

10.240 (est)

EPA Substance Registry System

Stigmast-4-en-3-one (1058-61-3)

B-SITOSTENONE Usage And Synthesis

Uses

β-Sitostenone is a sterols that can be isolated from Cochlospermum vitifolium.β-Sitostenone inhibits tyrosinase activity, and has anti-melanogenic and anti-tumor activities[1][2][3].

Definition

ChEBI: Beta-sitostenone is a steroid and a C29-steroid. It has a role as a metabolite. It derives from a hydride of a stigmastane.

IC 50

Human Endogenous Metabolite

References

[1] Aguilar-Guadarrama AB, et al. Flavonoids, Sterols and Lignans from Cochlospermum vitifolium and Their Relationship with Its Liver Activity. Molecules. 2018 Aug 5;23(8):1952. DOI:10.3390/molecules23081952

[2] Chu CW, et al. Biofunctional Constituents from Michelia compressa var. lanyuensis with Anti-Melanogenic Properties. Molecules. 2015 Jul 3;20(7):12166-74. DOI:10.3390/molecules200712166

[3] Fan SQ, et al. Sarocladione, a unique 5,10:8,9-diseco-steroid from the deep-sea-derived fungus Sarocladium kiliense. Org Biomol Chem. 2019 Jun 18;17(24):5925-5928. DOI:10.1039/c9ob01159e
[4] SUPINYA TEWTRAKUL  Sanan S. Effects of compounds from Kaempferia parviflora on nitric oxide, prostaglandin E2 and tumor necrosis factor-alpha productions in RAW264.7 macrophage cells[J]. Journal of ethnopharmacology, 2008, 120 1: Pages 81-84. DOI: 10.1016/j.jep.2008.07.033

[5] KHINE SWE NYUNT. Isolation of antitrypanosomal compounds from Vitis repens, a medicinal plant of Myanmar.[J]. Natural Product Communications, 2012, 7 5: 609-610.


[6] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.

[7] RUBY LISA ALEXANDER-LINDO  Muraleedharan G N  E Y St A Morrison. Hypoglycaemic effect of stigmast-4-en-3-one and its corresponding alcohol from the bark of Anacardium occidentale (cashew).[J]. Phytotherapy Research, 2004, 18 5: 403-407. DOI: 10.1002/ptr.1459

B-SITOSTENONE(1058-61-3)Related Product Information

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