KF31327
KF31327 Basic information
- Product Name:
- KF31327
- Synonyms:
-
- KF31327
- 3-ethyl-8-[[2-[4-(hydroxymethyl)piperidin-1-yl]phenyl]methylamino]-1H-imidazo[4,5-g]quinazoline-2-thione
- Thioquinapiperifil
- 2H-Imidazo[4,5-g]quinazoline-2-thione, 3-ethyl-1,3-dihydro-8-[[[2-[4-(hydroxymethyl)-1-piperidinyl]phenyl]methyl]amino]-
- KF-31327 free base
- Thioquinapiperfil
- CAS:
- 220060-39-9
- MF:
- C24H28N6OS
- MW:
- 448.58
- Mol File:
- 220060-39-9.mol
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KF31327 Usage And Synthesis
Biological Activity
Thioquinapiperifil (KF31327 free base) is a potent, selective, and noncompetitive inhibitor of phosphodiesterase (PDE-5) (IC50 of 0.074 nM) for sexual maturation studies.
in vitro
Thioquinapiperifil can be found in dietary supplements. Thioquinapiperifil (KF31327 free base) (0.1-10 μM) concentration dependently inhibits platelet aggregation. In the absence of nitroglycerin, higher concentrations 1 and 10 μM of Thioquinapiperifil (KF31327 free base) are required to inhibit platelet aggregation.
target
| PDE5 0.074 nM (IC 50 ) | PDE1 380 nM (IC 50 ) | PDE2 670 nM (IC 50 ) | PDE3 38 nM ( IC 50 ) | PDE4 800 nM (IC 50 ) |
KF31327Supplier
BOC Sciences
- Tel
- 1-631-485-4226; 16314854226
- info@bocsci.com
ChemStrong Scientific Co.,Ltd
- Tel
- 0755-0755-66853366 13670046396
- sales@chem-strong.com
BOC Sciences
- Tel
- 16314854226
- info@bocsci.com
Wuhan Greenkj Pharmaceutical Technology Co., Ltd.
- Tel
- 15608630565
- greenkjpharm@163.com
Shenzhen SUNGENING Bio-Medical Co., Ltd.
- Tel
- 0755-28967200 13631290199
- wxf@sungening.com
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KF31327(220060-39-9)Related Product Information
- Desmethyl Fondenafil
- Desethyl Carbodenafil
- 2-Ethoxybenzoyl chloride
- N-Des[2-(1-methyl-2-pyrrolidinyl)ethyl] Udenafil
- 1H-Pyrazolo[4,3-d]pyriMidine, 3-(2-Methylpropyl)-
- 5-DIMETHOXYMETHYL-BENZO[1,3]DIOXOLE
- 5-(2-ETHOXYPHENYL)-1-METHYL-3-N-PROPYL-1,6-DIHYDRO-7H-PYRAZOLO[4,3-D]-7-PYRIMIDINONE
- 1-Methyl-4-nitro-3-propyl-(1H)-pyrazole-5-carboxamide
- Propoxyphenyl ThiohoMosidenafil
- 1-METHYL-4-NITRO-3-PROPYL-1H-PYRAZOLE-5-CARBOXYLIC ACID
- 5-chloro-2-ethoxybenzoyl chloride
- 4-(2-Ethoxy benzamido)-1-methyl-3-n-propyl pyrazole-5-carboxamide.
- Sildenafil Chlorosulfonyl
- Sulfosalicylic acid
- Sildenafil Impurity F
- 5-chloro-2-ethoxybenzoic acid
- 5-CHLOROSULFONYL-2-ETHOXYBENZOIC ACID
- 2-ETHOXY-5-[(4-METHYLPIPERAZIN-1-YL)SULFONYL]BENZOIC ACID