16α-Hydroxy-24-methylene-3-oxo-5α-lanosta-7,9(11)-diene-21-oic acid Chemical Properties

Melting point:

265-266℃

Boiling point:

620.3±55.0 °C(Predicted)

Density 

1.11±0.1 g/cm3(Predicted)

storage temp. 

4°C, protect from light

solubility 

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

form 

Powder

pka

4.63±0.10(Predicted)

color 

White to off-white

InChIKey

OWVUHYZGACFYHI-SUIRJFICNA-N

SMILES

C1(=O)C([C@@]2([H])[C@](C)(CC1)C1C([C@]3([C@@](CC=1)(C)[C@@H]([C@H](C)CCC(=C)C(C)C)[C@H](O)C3)C(O)=O)=CC2)(C)C |&1:3,5,11,12,16,17,26,r|

CAS DataBase Reference

465-18-9

16α-Hydroxy-24-methylene-3-oxo-5α-lanosta-7,9(11)-diene-21-oic acid Usage And Synthesis

Chemical Properties

White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Poria cocos.

Uses

Polyporenic acid C is a lanostane-type triterpenoid isolated from P. cocos. Polyporenic acid C induces cell apoptosis through the death receptor-mediated apoptotic pathway without the involvement of the mitochondria. Polyporenic acid C is promising agent for lung cancer therapy[1].

Biological Activity

Polyporenic acid C is a lanostane-type triterpenoid isolated from P. cocos. It induces apoptosis through the death receptor-mediated apoptotic pathway without the involvement of mitochondria. It has the potential to be used in lung cancer research.

target

PARP | Caspase | PI3K | Akt | p53

References

[1] Ling H, et al. Polyporenic acid C induces caspase-8-mediated apoptosis in human lung cancer A549 cells.Mol Carcinog.?2009 Jun;48(6):498-507. DOI:10.1002/mc.20487

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