(R)-3-PHENYL-3-([4-(4-PYRIDIN-4-YL-PHENYL)-THIOPHENE-2-CARBONYL]-AMINO)-PROPIONIC ACID
(R)-3-PHENYL-3-([4-(4-PYRIDIN-4-YL-PHENYL)-THIOPHENE-2-CARBONYL]-AMINO)-PROPIONIC ACID Basic information
- Product Name:
- (R)-3-PHENYL-3-([4-(4-PYRIDIN-4-YL-PHENYL)-THIOPHENE-2-CARBONYL]-AMINO)-PROPIONIC ACID
- Synonyms:
-
- (R)-3-PHENYL-3-([4-(4-PYRIDIN-4-YL-PHENYL)-THIOPHENE-2-CARBONYL]-AMINO)-PROPIONIC ACID
- BENZENEPROPANOIC ACID, B-[[[4-[4-(4-PYRIDINYL)PHENYL]-2-THIENYL]CARBONYL]AMINO]-, (BR)-
- PF 00356231
- PF-356231
- Benzenepropanoic acid, β-[[[4-[4-(4-pyridinyl)phenyl]-2-thienyl]carbonyl]amino]-, (βR)-
- PF 356231, MMP-12 inhibitor
- CAS:
- 766536-21-4
- MF:
- C25H20N2O3S
- MW:
- 428.5
- Mol File:
- 766536-21-4.mol
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(R)-3-PHENYL-3-([4-(4-PYRIDIN-4-YL-PHENYL)-THIOPHENE-2-CARBONYL]-AMINO)-PROPIONIC ACID Chemical Properties
- form
- Yellow solid.
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(R)-3-PHENYL-3-([4-(4-PYRIDIN-4-YL-PHENYL)-THIOPHENE-2-CARBONYL]-AMINO)-PROPIONIC ACID Usage And Synthesis
Uses
PF-00356231 hydrochloride is a specific, non-peptidic, non-zinc chelating ligand and inhibitor of matrix metalloproteinase MMP-12 (IC50=1.4 μM). PF-00356231 hydrochloride binds to MMP-12 and forms PF-00356231/MMP-12 complex. PF-00356231 hydrochloride shows potency against MMP-13, MMP-8, MMP-9, MMP-3 with IC50s of 0.00065, 1.7, 0.98, 0.39 μM, respectively[1].
References
[1] Morales R, et al. Crystal structures of novel non-peptidic, non-zinc chelating inhibitors bound to MMP-12. J Mol Biol. 2004 Aug 20;341(4):1063-76. DOI:10.1016/j.jmb.2004.06.039
(R)-3-PHENYL-3-([4-(4-PYRIDIN-4-YL-PHENYL)-THIOPHENE-2-CARBONYL]-AMINO)-PROPIONIC ACIDSupplier
Shanghai EFE Biological Technology Co., Ltd.
- Tel
- 021-65675885 18964387627
- info@efebio.com
BOC Sciences
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- info@bocsci.com
Jinan Jiuli Biotechnology Co. , Ltd.
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- 15865264761
- 486064515@qq.com
Nanjing Shizhou Biology Technology Co.,Ltd
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- 025-85560043 15850508050
- cindy.huang@synzest.com
Enzo Biochem Inc
- Tel
- Enzo Biochem Inc. 13797054060
- Enzoname@qq.com
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(R)-3-PHENYL-3-([4-(4-PYRIDIN-4-YL-PHENYL)-THIOPHENE-2-CARBONYL]-AMINO)-PROPIONIC ACID(766536-21-4)Related Product Information
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- (R)-3-PHENYL-3-([4-(4-PYRIDIN-4-YL-PHENYL)-THIOPHENE-2-CARBONYL]-AMINO)-PROPIONIC ACID