ISOBAVACHALCONE Chemical Properties

Melting point:

156.8-157.8 °C(Solv: ethyl acetate (141-78-6); hexane (110-54-3))

Boiling point:

549.0±50.0 °C(Predicted)

Density 

1.243±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

solubility 

Soluble in DMSO

form 

Yellow oil.

pka

7.99±0.40(Predicted)

color 

Yellow-orange

ISOBAVACHALCONE Usage And Synthesis

Uses

Isobavachalcone is an inhibitor of platelet aggregation.

Definition

ChEBI: A member of the class of chalcones that is trans-chalcone substituted by hydroxy groups at positions 4, 2' and 4' and a prenyl group at position 3'.

Biological Activity

Isobavachalcone is a chalcone isolated from multipurpose medical plant Psoralea corylifolia th at inhibits LPS-induced ICAM-1 expression and leukocyte adhesion to brain endothelial cells. It appears th at isobavachalcone modulates both MyD88-dependent and TRIF-dependent signaling of toll-like receptor 4 (TLR4). Isobavachalcone significantly inhibits both oligomerization and fibrillization of Aβ42. Isobavachalcone exhibits a wide spectrum of biological activities including antioxidative, antiplatelet, antimicrobial, anti-inflammatory, antitumor, and neuroprotective.

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