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DRACORHODIN PEROCHLORATE

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DRACORHODIN PEROCHLORATE Basic information

Product Name:
DRACORHODIN PEROCHLORATE
Synonyms:
  • DRACORHODIN PEROCHLORATE
  • Dracohodin perochlorate
  • Dracorhodin perchlorate
  • 7-Hydroxy-5-methoxy-6-methyl-2-phenyl-1-benzopyrylium perchlorate
  • BRN 1977317
  • Dracorhodin perochlorate|||Dracohodin perochlorate
  • 7-Hydroxy-5-methoxy-6-methyl-2-phenylchromenylium perchlorate
  • Dracorhodin perchlorate-RM
CAS:
125536-25-6
MF:
C17H15ClO7
MW:
366.75
Product Categories:
  • reagent
  • standard substance
Mol File:
125536-25-6.mol
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DRACORHODIN PEROCHLORATE Chemical Properties

storage temp. 
Amber Vial, -20°C Freezer, Under inert atmosphere
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
color 
Very Dark Orange
Stability:
Moisture Sensitive
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DRACORHODIN PEROCHLORATE Usage And Synthesis

Chemical Properties

Orange-yellow crystalline powder, soluble in methanol, derived from dragon's blood.

Uses

Dracorhodin Perchlorate is an apoptotic agent, inducing apoptosis in fibroblasts from human skin hypertrophic scars. Antioxidant.

in vivo

Dracorhodin perchlorate (2.5-10 μg/mL；applied as an ointment；twice daily；0-14 days) promotes wound healing in rats, as evidenced by increased wound healing rate, enhanced fibroblast proliferation in wound tissue, and up -regulation of phosphorylated-ERK in wound tissue[3].
Dracorhodin perchlorate (200 μg/mL; topical application) promotes skin wound healing, collagen deposition, and microvascular formation in diabetic rats by regulating the TLR4 pathway and related inflammatory factors[6].
Dracorhodin perchlorate (5-20 mg/kg; i.p.; every other day; 30 d) lowers blood glucose, raises insulin levels, enhances Pdx1 expression, increases islet size and number, and shows protective effects on islets and β-cells in diabetic mice[7].

Animal Model:Male Sprague-Dawley rats (170-220 g, clean grade, 7-week-old approximately)+diabetes mellitus model induced by Streptozotocin (HY-13753) injection and high-fat diet[6]
Dosage:200 μg/mL (dissolved in DMSO and made into ointment with Vaseline)
Administration:Topical application
Result:Accelerated the wound healing in diabetic rats.
Increased the wound healing rate.
Promoted collagen deposition and inhibited scar formation.
Increased the number of microvessels.
Reduced the activation of the TLR4 pathway, decreased the mRNA and protein expressions of inflammatory factors, increased eNOS protein expression and NO content in the later stage of wound healing.

IC 50

TLR4; Caspase 3

DRACORHODIN PEROCHLORATESupplier

Chembest Research Laboratories Limited
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Adamas Reagent, Ltd.
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Innochem(Beijing) Technology Co.,Ltd.
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010-56541685 13070143590
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Hunan Hui Bai Shi Biotechnology Co., Ltd.
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0731-85526065 13308475853
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ivy@hnhbsj.com
ShangHai YuanYe Biotechnology Co., Ltd.
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021-61312847 13636370518
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shyysw007@163.com
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