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Angiotensin acetate

Basic information Safety Supplier Related

Angiotensin acetate Basic information

Product Name:
Angiotensin acetate
Synonyms:
  • [VAL5]-ANGIOTENSIN II
  • [VAL5] ANGIOTENSIN II HUMAN
  • ASP-ARG-VAL-TYR-VAL-HIS-PRO-PHE
  • DRVYVHPF
  • 5-L-Valine angiotensin II)
  • Angiotensin II 5-valine (Valine angiotensin II
  • Valine angiotensin II
  • VALINE ANGIOTENSIN II;5-L-VALINE ANGIOTENSIN II
CAS:
58-49-1
MF:
C49H69N13O12
MW:
1032.15
Mol File:
58-49-1.mol
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Angiotensin acetate Chemical Properties

storage temp. 
-20°C
form 
powder
Density 
1.45±0.1 g/cm3(Predicted)
pka
3.56±0.10(Predicted)
color 
White to off-white
Water Solubility 
Water : ≥ 257.5 mg/mL (249.48 mM)
Sequence
H-Asp-Arg-Val-Tyr-Val-His-Pro-Phe-OH
InChIKey
JVCJXRGXGITABA-IAQGTVMASA-N
CAS DataBase Reference
58-49-1
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Safety Information

WGK Germany 
3
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Angiotensin acetate Usage And Synthesis

Uses

Angiotensin acetate is a biologically active peptide and a derivative of [5-?valine]?angiotensin II.

Definition

ChEBI: Val(5)-angiotensin II is an angiotensin II.

Biochem/physiol Actions

Angiotensin II analog that is an agonist AT1 angiotensin receptors.

in vivo

By day 12, systolic blood pressure (SBP) increases significantly in Angiotensin II 5-valine infused rats (197±7 mm Hg).The development of hypertension in ANG II infused rats is prevented by losartan treatment. Blood and kidney samples are harvested, subjected to HPLC to separate Angiotensin II 5-valine (exogenous) from Ile5-ANG II (endogenous) and the fractions are measured by radioimmunoassay. In the Angiotensin II 5-valine infused rats treated with losartan, total plasma ANG II levels are elevated to a greater extent than in rats not treated with losartan (289±20 v 119±14 fmol/mL). However, losartan markedly decrease by 88% the enhancement of intrarenal Val5-ANG II content that occurred in the rats infused with Val5-ANG II alone[1].

Angiotensin acetateSupplier

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