AURANTIO-OBTUSIN
AURANTIO-OBTUSIN Basic information
- Product Name:
- AURANTIO-OBTUSIN
- Synonyms:
-
- 1,3,7-Trihydroxy-2,8-diMethoxy-6-Methyl-9,10-anthracenedione
- Aurantio-obtusifolin
- AURANTIO-OBTUSIN
- 1,3,7-Trihydroxy-2,8-dimethoxy-6-methylanthracene-9,10-dione
- URANTIO-OBTUSIN
- Aurantioobtusin, 98%, from Catsia tora Linn
- 9,10-Anthracenedione, 1,3,7-trihydroxy-2,8-dimethoxy-6-methyl-
- 67979-25-3 AURANTIO-OBTUSIN
- CAS:
- 67979-25-3
- MF:
- C17H14O7
- MW:
- 330.29
- Product Categories:
-
- chemical reagent
- pharmaceutical intermediate
- phytochemical
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Mol File:
- 67979-25-3.mol
AURANTIO-OBTUSIN Chemical Properties
- Melting point:
- 265-266 °C
- Boiling point:
- 594.6±50.0 °C(Predicted)
- Density
- 1.510±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- Soluble in chloroform, DMSO and methan
- form
- powder
- pka
- 6.32±0.20(Predicted)
- color
- Orange
Safety Information
- Safety Statements
- 24/25
- HS Code
- 29389090
AURANTIO-OBTUSIN Usage And Synthesis
Description
Aurantioobtusin is an anthraquinone originally isolated from Cassia seeds with diverse biological activities. It inhibits rat lens aldose reductase (RLAR) in vitro (IC50 = 13.6 μM). Aurantioobtusin (10 and 100 μM) activates the aryl hydrocarbon receptor (AhR) in a concentration-dependent manner. It inhibits rat platelet aggregation induced by arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607), ADP, and collagen. Aurantioobtusin induces vasorelaxation in isolated precontracted rat mesenteric artery rings, an effect that is inhibited by the PI3K inhibitor LY290042 or inhibition of endothelial nitric oxide synthase (eNOS). It is larvicidal against A. gambiae mosquitoes (LD50 = 10 ppm).
Uses
A compound found in herbal remedies, believed to have an effect on blood platelet aggregation and lower blood lipid count
Definition
ChEBI: A trihydroxyanthraquinone that is 1,3,7-trihydroxy-9,10-anthraquinone which is by methoxy groups at positions 2 and 8, and by a methyl group at position 6.
in vivo
Aurantio-obtusin (5-15 mg/kg; Oral administration; Single dose) in HFSW-induced mice reduces HFSW-induced lipid droplet accumulation and extensive steatosis in a dose-dependent manner[3].
Aurantio-obtusin (5-15 mg/kg; Oral administration; A single dose) inhibits fatty acid synthesis, promotes FAO and activates AMPK signaling and autophagy in HFSW-induced mice [3].
| Animal Model: | C57BL/6J mice model[3] |
| Dosage: | 5 mg/kg, 10 mg/kg, 15 mg/kg |
| Administration: | Oral gavage (p.o.), feeding with HFSW diet for 4 weeks then giving different dose of Aurantio-obtusin for another 4 weeks. |
| Result: | Decreased the levels of TG and TC in liver and TG, ALT and AST in serum induced by HSFW. Reduced the number and size of fat droplets in liver cells. Significantly increased AMPK phosphorylation in HFSW-induced mice. |
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