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Periplocoside

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Periplocoside Basic information

Product Name:
Periplocoside
Synonyms:
  • Periplocoside
  • 3β-[(4-O-β-D-Glucopyranosyl-3-O-methyl-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-5,14-dihydroxy-5β,14β-card-20(22)-enolide
  • Periplocin
  • Card-20(22)-enolide, 3-[(2,6-dideoxy-4-O-β-D-glucopyranosyl-3-O-methyl-β-D-ribo-hexopyranosyl)oxy]-5,14-dihydroxy-, (3β,5β)-
  • 4-((3S,5S,8R,9S,10R,13R,14S,17R)-5,14-Dihydroxy-3-(((2R,4S,5R,6R)-4-methoxy-6-methyl-5-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)furan-2(5H)-one
  • Periplocin, 10 mM in DMSO
CAS:
13137-64-9
MF:
C36H56O13
MW:
696.82
Mol File:
13137-64-9.mol
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Periplocoside Chemical Properties

Melting point:
205°C
Boiling point:
610.7°C (rough estimate)
alpha 
D20 +32°
Density 
1.1241 (rough estimate)
refractive index 
1.7500 (estimate)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
DMSO : 250 mg/mL (358.77 mM; Need ultrasonic)
form 
powder
pka
12.89±0.70(Predicted)
color 
White
Water Solubility 
7.937g/L(cold water)
InChIKey
KWBPKUMWVXUSCA-WVOVULELNA-N
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Safety Information

Toxicity
LD in rabbits, rats (mg/kg): 10, 480 s.c. (MacKeith)
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Periplocoside Usage And Synthesis

Chemical Properties

Soluble in methanol and DMSO Derived from Periploca odorifera

Uses

Periplocin can be used to improve bone health to prevent, alleviate, or treat osteoporosis.

in vivo

Periplocin (5-20 mg/kg; intraperitoneal injection; daily; for 14 days; female SCID mice) treatment represses the growth of hepatocellular carcinoma (HCC) in xenograft tumor model in mice[2].

Animal Model:Female SCID mice (6-8 weeks old) injected with Huh-7 cells[2]
Dosage:5 mg/kg, 20 mg/kg
Administration:Intraperitoneal injection; daily; for 14 days
Result:Repressed the growth of hepatocellular carcinoma (HCC) in xenograft tumor model in mice.

PeriplocosideSupplier

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Chengdu Biopurify Phytochemicals Ltd.
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+86-028-82633397 18982077548
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cwb1@biopurify.cn
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