H-ABU-OME HCL Chemical Properties

Melting point:

116-117℃

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

solubility 

Aqueous Acid (Sparingly), DMSO (Slightly), Methanol (Slightly)

form 

Solid

color 

White to Off-White

H-ABU-OME HCL Usage And Synthesis

Uses

Intermediate in the preparation of Ergonovine (E597800) derivatives.

Synthesis

The general procedure for the synthesis of DL-2-aminobutyric acid methyl ester hydrochloride from methanol and Boc-L-2-aminobutyric acid was as follows: 10.0 g (49.2 mmol) of Boc-L-2-aminobutyric acid was dissolved in 100 mL of methanol, and 6 mL (82.2 mmol) of thionyl chloride was added slowly and dropwise at 0 °C. The reaction mixture was stirred at room temperature for 14 h before the solvent was removed by vacuum evaporation. A product of 7.6 g (101% yield) was obtained. The structure of the product was confirmed by electrospray mass spectrometry (ES-MS) and the molecular ion peak (M + H)+ was observed as 118.

References

[1] Patent: US2010/144681, 2010, A1. Location in patent: Page/Page column 67

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